Contribution to bacterial mutagenicity from nitro-pah compounds in ambient aerosols

Siak, J.; Chan, Tai L.; Gibson, Thomas L.; Wolff, George T.

doi:10.1016/0004-6981(85)90104-0

Cited by 60 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in our previous studies (Siak et al, 1985;Wolff et al, 1986a), the polar fractions (Fr 1-4) dominate the mutagenicity and account for more than 70% of the direct-acting mutagenic activity whch is comparable to 64% in the 1981 Detroit samples. In both studies, fraction 2 has the single largest fraction accounting for 34% of the activity in the 1981 Detroit samples and 36% of the activity from the 1985 Warren samples.…”

Section: Mutagenicity Profiles During the Episodessupporting

confidence: 80%

“…Fractions 1-4 (Fr 1-4) contained mostly polar compounds, Fr 5-8 the oxygenated or substituted PAH compounds, Fr 9-10 the PAH compounds, and Fr 11-16 the aliphatic compounds. Details of the procedures have been described in our earlier reports (Siak et al, 1985;Wolff et al, 1986b;Pederson and Siak, 1981a). Because of the sample mass requirements of the in vitro mutagenicity assay and the availability of other concurrent air quality data, only 24 out of the 56 pairs of day/night samples (including a data set of 10 consecutive days) were judged to be acceptable for detailed mutagenicity analysis.…”

Section: Sample Collection and Extractionmentioning

confidence: 99%

“…Our previous studies (Siak et al, 1985;Wolff et al, 1986b) have shown that nitrated polycyclic aromatic hydrocarbon (PAH) compounds accounted for less than 5% of the total direct-acting mutagenicity in ambient particles in southeastern Michigan. A plausible hypothesis is that interactions between particles and oxidants can lead to the transformation of emitted species such as nitrated-PAH and nonpolar compounds to less mutagenic polar derivatives.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Temporal Patterns of Bacterial Mutagenicity on Ambient Aerosols in Southeastern Michigan

Chan

Siak

Korsog

et al. 1989

Aerosol Science and Technology

Self Cite

View full text Add to dashboard Cite

The temporal and diurnal patterns of particulate-bound mutagens in the atmosphere were examined for a twomonth period in the summer of 1985. Daily PM-10 samples were collected at 0900-2100 and 2100-0900 along with other air quality measurements from a suburban site in southeast Michigan. The paired samples were collected daily in order to examine day /night variations. Each particulate sample was extracted and separated into 16 different fractions based on polarity before Ames tests were conducted on each fraction to determine the bacterial mutagenic activities in TA98 and TA98/DNP6. Other air quality parameters measured included fine particle mass (diameter less than 2.5 pm), sulfate, sulfur dioxide, nitrogen oxides, nitric acid, ozone, carbonaceous aerosols, some trace elements, and pertinent meteorological data. The results show that the four most polar fractions accounted for at least 70% of the mutagenicity.The highest levels of mutagenic activity occurred during two different types of meteorological conditions. The first type was associated with the long-range transport of coal combustion emissions from south of Michigan's border, whereas the second type was associated with stagnant atmospheric conditions and an accumulation of locally-emitted combustion products. Although nighttime mutagenic activity was slightly higher than daytime activity on some days, rigorous statistical tests indicated that the differences were not significant at the 95% confidence level. However, the mutagenicity profiles of individual paired day /night samples suggest that, under appropriate meteorological conditions, the polar mutagenic species can be formed via nighttime chemical reactions and/or degraded to less mutagenic form via photochemical reactions during the day.

show abstract

Section: Mutagenicity Profiles During the Episodessupporting

confidence: 80%

Section: Sample Collection and Extractionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Temporal Patterns of Bacterial Mutagenicity on Ambient Aerosols in Southeastern Michigan

Chan

Siak

Korsog

et al. 1989

Aerosol Science and Technology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The mutagenic activity of the hydroxynitropyrenes is still uncertain but probably contributes part of the activity found in the very polar fractions of POM extracts. 7 Table IV also shows the distribution of mutagenic activity among the nonpolar, moderately polar, and very polar POM fractions separated by the preparative TLC procedure.…”

Section: Resultsmentioning

confidence: 99%

“…Bermuda Re 8/82 (9) 1,2/83 (6) 0.28 (±0.26) 0.32 (±0.20) Delaware Ru 7,8/82 (7) Warren S 12/82 (7) 6/84 ultraviolet irradiation showed a sixfold increase in mutagenicity due to the simulated atmospheric processes. 3 Under these conditions, a 90 percent decrease in BaP concentration and increases in 1-NP, DNP, and HNP also occurred.…”

Section: Site 3 Mo/yr (N)b Bapmentioning

confidence: 95%

Sources of Nitroaromatic Mutagens in Atmospheric Polycyclic Organic Matter

Gibson

1986

Journal of the Air Pollution Control Association

View full text Add to dashboard Cite

Chromatographic methods for carcinogenic/mutagenic nitropolycyclic aromatic hydrocarbons

Hayakawa

2000

Biomed. Chromatogr.

View full text Add to dashboard Cite

Nitropolycyclic aromatic hydrocarbons (NPAHs), which are known to be carcinogenic and/or mutagenic, are considered to be one of the air pollutants that cause lung cancer. In the last two decades, a number of sensitive and selective methods have been developed for the determination of NPAHs and related compounds in environmental and biological samples. This paper describes the state of the art of the methods and applications.

show abstract

Contribution to bacterial mutagenicity from nitro-pah compounds in ambient aerosols

Cited by 60 publications

References 23 publications

Temporal Patterns of Bacterial Mutagenicity on Ambient Aerosols in Southeastern Michigan

Temporal Patterns of Bacterial Mutagenicity on Ambient Aerosols in Southeastern Michigan

Sources of Nitroaromatic Mutagens in Atmospheric Polycyclic Organic Matter

Chromatographic methods for carcinogenic/mutagenic nitropolycyclic aromatic hydrocarbons

Contact Info

Product

Resources

About