Influence of medical comorbidities, smoking, and alcohol on mycosis fungoides progression and mortality Dear Editor, Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Previous reports have described racial, demographic, and socioeconomic disparities in MF progression-free survival (PFS) 1,2 and found increased levels of homocysteine, high sensitivity C-reactive protein, low-density lipoprotein, and total cholesterol in MF patients compared to healthy controls, suggesting higher cardiovascular risk. 3 Moreover, significantly higher rates of congestive heart failure, hypertension, and hyperlipidemia have been observed in MF patients in comparison to the general population. 4 However, current studies have not examined whether these risk factors impact MF disease progression or death. Therefore, we examined the influence of cardiac, metabolic, hematologic, and auto-*P < 0.05. **P < 0.01. ***P < 0.001.