Contribution of reactive oxygen species to the anticancer activity of aminoalkanol derivatives of xanthone

Sypniewski, Daniel; Szkaradek, Natalia; Loch, Tomasz; Waszkielewicz, Anna M.; Gunia‐Krzyżak, Agnieszka; Matczyńska, Daria; Sołtysik, Dagna; Marona, Henryk; Bednarek, Ilona

doi:10.1007/s10637-017-0537-x

Cited by 17 publications

(7 citation statements)

References 45 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many investigations have found that the ROS levels in cancer cells are significantly associated with anticancer effect including proliferation inhibition and apoptosis induction. 30,[56][57][58][59] In order to explore the effect of Re-CDs on the inhibition of cancer cells, we measured the ROS level in A375 cells after they were treated with Re-CDs, by a flow cytometer. Results are displayed in Figure 6.…”

Section: Effect Of Re-cds On Ros Generation In Cancer Cellsmentioning

confidence: 99%

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

Hua

Song

et al. 2018

IJN

View full text Add to dashboard Cite

BackgroundFluorescent carbon-based nanomaterials have promising properties such as biosensing, cell imaging, tracing and drug delivery. However, carbon dots (CDs) with specific inherent biological functions have not been investigated. Ginsenosides are the components with multiple bioactivities found in plants of the genus Panax, which have attracted a lot of attention for their anticancer effect.Materials and methodsIn this study, we prepared a kind of novel photoluminescent CDs from ginsenoside Re by one-step hydrothermal synthesis method. The conventional methods including transmission electron microscopy, Fourier transform infrared spectroscopy, HPLC and fluorescence spectrum were used for characterization of CDs. In vitro anticancer effect was investigated by cytotoxicity assay, flow cytometry and Western blot analysis.ResultsThe as-prepared Re-CDs had an average diameter of 4.6±0.6 nm and excellent luminescent properties. Cellular uptake of Re-CDs was facilitated by their tiny nanosize, with evidence of their bright excitation-dependent fluorescent images. Compared with ginsenoside Re, the Re-CDs showed greater inhibition efficiency of cancer cell proliferation, with lower toxicity to the normal cells. The anticancer activity of Re-CDs was suggested to be associated with the generation of large amount of ROS and the caspase-3 related cell apoptosis.ConclusionHopefully, the dual functional Re-CDs, which could both exhibit bioimaging and anticancer effect, are expected to have great potential in future clinical applications.

show abstract

Section: Effect Of Re-cds On Ros Generation In Cancer Cellsmentioning

confidence: 99%

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

Hua

Song

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…It was reported that aminoalkanol-xanthones could generate the overexpression of manganese superoxide dismutase, thus decreasing reactive oxygen species (ROS)-mediated cell senescence. The aminoalkanol-xanthones also lead mitochondrial dysfunction and cellular apoptosis on the evaluated cancer cell lines [107]. The xanthone derivatives act as anticancer agents through several mechanisms of action.…”

Section: In Vitro Anticancer Assay Of Xanthone Derivativesmentioning

confidence: 97%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

View full text Add to dashboard Cite

The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.

show abstract

“…There are indications that generation of ROS plays a major role in the anticancer effect of biologically active compounds (Khan et al, 2021; Sypniewski et al, 2018). Furthermore, targeting the antioxidant defense mechanism of cancer cells and modulation of excessive ROS generation has also been identified as a therapeutic mechanism for inhibiting uncontrolled cell proliferation (Liu et al, 2014; Wang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative and apoptosis‐inducing effects of aqueous extracts from Ecklonia maxima and Ulva rigida on HepG2 cells

Olasehinde

Olaniran

2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

This study examined the antiproliferative and apoptotic‐inducing effects of Ecklonia maxima (KP) and Ulva rigida (URL) extracts in the human liver cancer (HepG2) cell line model. HepG2 cells were cultured and grown in an incubator (5% CO2) at 37°C. Cell viability was determined, while the effect of the extracts on apoptosis, ROS production, mitochondria membrane potential, and antioxidant enzymes were also assessed. KP and URL induced cytotoxic effects on HepG2 cells at the concentrations tested (0–1000 μg/ml). The morphological characteristics of the cells after treatment with KP and URL revealed cell shrinkage of the nucleus, cell injury, and damage compared to the control. The fluorescent micrographs from the apoptotic assay revealed induction of apoptosis and necrosis in HepG2 cells after treatment with KP and URL (200 and 400 μg/ml). The extracts also induced ROS production and reduced mitochondria membrane potential in HepG2 cells. The apoptotic‐inducing effects, activation of ROS generation, and disruption of antioxidant enzymes are associated with the cytotoxic effects of the seaweed extracts. KP and URL showed good anticancer properties and could be explored as a good source of nutraceuticals, food additives, and dietary supplements to prevent uncontrolled proliferation of HepG2 cells. Practical applications Seaweeds are reservoirs of nutrients and naturally occurring biologically active compounds, including sterols, phlorotannins, and polyunsaturated fatty acids. Due to the presence of these compounds, they are used as emulsifying agents, nutraceuticals, and additives in functional foods. Evidence suggests that seaweed bioactives may inhibit uncontrolled cell proliferation and induce apoptosis in cancer cells. Hence, exploring the antiproliferative and apoptotic‐inducing effects of Ecklonia maxima and Ulva rigida will provide insights into their anticancer potentials as functional foods and nutraceuticals.

show abstract

Contribution of reactive oxygen species to the anticancer activity of aminoalkanol derivatives of xanthone

Cited by 17 publications

References 45 publications

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

Antiproliferative and apoptosis‐inducing effects of aqueous extracts from Ecklonia maxima and Ulva rigida on HepG2 cells

Contact Info

Product

Resources

About