Contribution of phytoextracts in challenging the biofilms of pathogenic bacteria

Ray, Rina Rani; Pattnaik, Smaranika

doi:10.1016/j.bcab.2023.102642

Cited by 7 publications

(3 citation statements)

References 91 publications

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“…There are several plants, the extracts from which are potentially anti-biofilm compounds. Antimicrobial and antifungal compounds from plant extracts have been tested for their effectiveness against bacteria and fungi, both of which can form biofilms [ 123 , 124 ]. In oral health, oral fungal infections are a common occurrence, especially due to Candida species.…”

Section: Methods Of Combating Biofilmsmentioning

confidence: 99%

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Ali,

Zahra,

Kamthan

et al. 2023

Microorganisms

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Biofilms are complex communities of microorganisms that grow on surfaces and are embedded in a matrix of extracellular polymeric substances. These are prevalent in various natural and man-made environments, ranging from industrial settings to medical devices, where they can have both positive and negative impacts. This review explores the diverse applications of microbial biofilms, their clinical consequences, and alternative therapies targeting these resilient structures. We have discussed beneficial applications of microbial biofilms, including their role in wastewater treatment, bioremediation, food industries, agriculture, and biotechnology. Additionally, we have highlighted the mechanisms of biofilm formation and clinical consequences of biofilms in the context of human health. We have also focused on the association of biofilms with antibiotic resistance, chronic infections, and medical device-related infections. To overcome these challenges, alternative therapeutic strategies are explored. The review examines the potential of various antimicrobial agents, such as antimicrobial peptides, quorum-sensing inhibitors, phytoextracts, and nanoparticles, in targeting biofilms. Furthermore, we highlight the future directions for research in this area and the potential of phytotherapy for the prevention and treatment of biofilm-related infections in clinical settings.

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Section: Methods Of Combating Biofilmsmentioning

confidence: 99%

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Ali,

Zahra,

Kamthan

et al. 2023

Microorganisms

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“…Garlic bulb extract is used to activate the antioxidant defense system in plants. Solvent extracts from Eucalyptus globulus and Anacardium occidentale using methanol and hexane extracts were used in the experiments as herbal preparations (Ray and Pattnaik, 2023). The present study was designed in search of promising alternative control strategies to old conventional insect control methods.…”

Section: Introductionmentioning

confidence: 99%

Bioefficacy of Some Botanical Extracts against Brinjal Fruit and Shoot Borer [Leucinodes orbonalis (Guenee); Lepidoptera, Pyrallidae)

Manzoor,

Hamza,

Javaid

et al. 2023

Plant Prot.

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Plant-based biopesticides such as extracts of neem and eucalyptus are gaining increasing attention as potential alternatives to synthetic pesticides due to their reduced toxicity to non-target species and the environment. The present study aimed to evaluate the efficacy of ethanolic and aqueous extracts of neem (Azadirachta indica A. Juss.) and eucalyptus (Eucalyptus citriodora Hook.) as biopesticides against the brinjal fruit and shoot borer (BFSB) (Leucinodes orbonalis), a major pest of brinjal (eggplant) crop. Experiments were conducted to determine the lethal concentration of both neem and eucalyptus extracts against BFSB larvae. The biopesticides were applied to brinjal fruit and their efficacy was evaluated by monitoring the mortality of BFSB larvae and pupae. The results showed that both neem and eucalyptus extracts were effective in controlling BFSB larvae, with the neem extract being slightly more toxic than the eucalyptus extract. A 5% concentration of ethanolic and aqueous extracts of neem caused 82% and 64% mortality of BFSB 3rd instar larvae, while the same concentration of eucalyptus extracts caused 73% mortality with 60% mortality, respectively. BFSB 5th instar larvae showed a decreased mortality as compared to 3rd instars. It concludes that the use of aqueous and ethanolic extracts of neem and eucalyptus could help to reduce the use of synthetic pesticides to control brinjal fruit and shoot borer. Further studies are needed to assess the long-term effectiveness and sustainability of these biopesticides in controlling BFSB and protecting brinjal crops.

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“…Globally, periodontal diseases pose a serious threat to public health because they affect a huge number of people worldwide and, if ignored, could result in tooth loss. One of the common oral bacteria present in the oral plaque of patients with periodontitis [ 1 ] and known to be actively involved in the progression of gingivitis is the Gram-negative anaerobic bacteria Porphyromonas gingivalis ( P. ginivalis ) [ 2 ]. On both soft and hard oral tissues, it is known to develop biofilms, an organized community of bacterial cells encased in a self-produced polymeric matrix [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Metronidazole Potentiation by Panax Ginseng and Symphytum officinale: A New Strategy for P. gingivalis Infection Control

2023

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The important periodontal disease pathogen Porphyromonas gingivalis produces thick biofilms that increase its pathogenicity. Finding natural antimicrobial agents is crucial because of the rise in antibiotic resistance. The purpose of this study was to determine if plant extracts such as Symphytum officinale (S) and Panax Ginseng (G) were effective against P. gingivalis separately and in combination with a common antibiotic, metronidazole (F). Six different dilutions were produced using the plant extracts in different concentrations and antibiotics separately and in combination with F, G, and S using the two-fold serial dilution technique. To evaluate the effects of these substances, biofilm inhibition experiments were conducted. Plaque samples were collected from periodontitis patients to isolate P. gingivalis, and a standard strain of P. gingivalis (ATCC 33277) was purchased. Additionally, Acylated Homoserine Lactones (AHLs) detection was carried out to look for any activity that would interfere with quorum sensing. GraphPad Prism was used for statistical analysis with a p-value < 0.05. The combinations of Symphytum officinale and metronidazole (S+F) showed the maximum effectiveness in biofilm inhibition (98.7%), which was slightly better than G+F (98.2%), with substantial variations in biofilm inhibition levels in different treatment regimes. Notably, the patient isolate was more active than the standard strain. Additionally, the plant extracts and their combinations at particular dilutions had notable inhibitory effects on the generation of AHL (p < 0.05). The study highlights the possibility of Symphytum officinale and Panax Ginseng as effective treatments for P. gingivalis biofilm and AHLs, both on their own and in combination with metronidazole. These organic substances may open the door to cutting-edge methods of treating periodontal disorders.

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Contribution of phytoextracts in challenging the biofilms of pathogenic bacteria

Cited by 7 publications

References 91 publications

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

Bioefficacy of Some Botanical Extracts against Brinjal Fruit and Shoot Borer [Leucinodes orbonalis (Guenee); Lepidoptera, Pyrallidae)

Metronidazole Potentiation by Panax Ginseng and Symphytum officinale: A New Strategy for P. gingivalis Infection Control

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