Metronidazole Potentiation by Panax Ginseng and Symphytum officinale: A New Strategy for P. gingivalis Infection Control

Ibrahim, S.; Al-Mizraqchi, Abbas S.; Haider, Julfikar

doi:10.3390/antibiotics12081288

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Ginseng extracts, in addition to their effects on cell proliferation and the expression of ALP and COL-1, have been shown to inhibit alveolar bone loss and MMP-9 expression in periodontal tissues, particularly in models of P. gingivalis -induced periodontal disease [ 78 , 79 , 80 , 81 ]. These findings indicate that ginseng extracts can modulate extracellular matrix remodeling processes, which are crucial for maintaining periodontal tissue architecture and function.…”

Section: Effects Of Ginsenosides On Periodontal Diseasementioning

confidence: 99%

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

2024

IJMS

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Ginsenosides, bioactive compounds from the genus Panax, have potential therapeutic effects on diverse ailments, including diabetes. Emerging evidence suggests their involvement in bone metabolism. The present review summarizes the current understanding of the effects of ginsenosides on osteoporosis, periodontal disease, and osteoarthritis. Their mechanisms of action include effects on osteoblasts, osteoclasts, periodontal ligament fibroblasts (PDLFs), and chondrocytes, which are pivotal in maintaining bone, periodontal tissue, and cartilage homeostasis. Ginsenosides may exert their beneficial effects by enhancing PDLF and osteoblast activity, suppressing osteoclast function, augmenting chondrocyte synthesis in the cartilage matrix, and mitigating connective tissue degradation. Moreover, they possess antioxidant, anti-inflammatory, antimicrobial, and anti-pyroptotic properties. Their efficacy in increasing bone density, ameliorating periodontitis, and alleviating osteoarthritis symptoms has been demonstrated in preclinical studies using animal models. In terms of their mechanism of action, ginsenosides modulate cellular differentiation, activity, and key signaling pathway molecules, such as mitogen-activated protein kinases (MAPKs), while also regulating various mediators. Furthermore, the symptomatic relief observed in animal models lends further credence to their therapeutic utility. However, to translate these preclinical findings into clinical practice, rigorous animal and clinical investigations are imperative to ascertain the safety, efficacy, and optimal dosing regimens in human subjects.

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Section: Effects Of Ginsenosides On Periodontal Diseasementioning

confidence: 99%

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

2024

IJMS

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Comparison of the Antibacterial Activity of Panax Ginseng and Symphytum Officinale with Metronidazole against P. gingivalis: An MIC and MBC Analysis

Ibrahim,

Al-Mizraqchi

2024

TODENTJ

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Background The RapID ANA II panel was used to evaluate bacterial responses, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were established. Aim This study aimed to investigate the antibacterial effects of Metronidazole, Symphytum Officinale, and Panax Ginseng on P. gingivalis Materials and Methods P. gingivalis strains, including strain ATCC 33277 and an isolate, were selected and prepared. A variety of test compounds, including Metronidazole, Symphytum Officinale, and Panax Ginseng, were procured and manufactured. A consistent technique was used to determine the MIC and MBC. We used the RapID ANA II panel to assess bacterial responses. Additionally, a suitable software was used to conduct the statistical analysis. Results The findings from the MIC and MBC tests showed notable variations and a noticeable impact of the combination therapy (G+F and S+F) in comparison to the individual drugs alone. Lower MIC and MBC values were seen when Panax Ginseng and Metronidazole (G+F) and Symphytum Officinale and Metronidazole (S+F) were combined, demonstrating a synergistic effect (p < 0.01). Positive results were found for ρ-Nitrophenyl-β, D-disaccharide (BLTS), σ-Nitrophenyl-β, D-galactoside (ONPG), ρ-Nitrophenyl-n-acetyl-β, D glucosaminide (NAG), ρ-Nitrophenylphosphate (PO4), Phenylalanine-β-naphthylamide (PAL), Pyrrolidonyl-β-naphthylamide (PYR), and Tryptophane (IND) in the RapID ANA II panel, whereas negative results were obtained for Urea (URE), ρ-Nitrophenyl-α, L-arabinoside (aARA), ρ-Nitrophenyl-α, D-glucoside (aGLU), ρ-Nitrophenyl-β, D-glucoside (BGLU), ρ-Nitrophenyl-α, D-galactoside (aGAL), ρ-Nitrophenyl-α, L-fucoside (aFUC), Proline-β-naphthylamide (PRO), and Serine-β-naphthylamide (SER). Conclusion Our study shows that combination therapies using Panax Ginseng and Symphytum Officnale with Metronidazole have increased antibacterial efficacy against P. gingivalis. These results point to the possibility of these herbal remedies complementing conventional medicine. In this study, the RapID ANA II panel helped identify and characterise P. gingivalis by offering useful insights into bacterial reactions. Nonetheless, it is necessary to conduct more studies to examine the therapeutic uses of these alternative P. gingivalis infection treatments.

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Histological Study to Evaluate the Effect of Local Application of Myrtus Communis Oil on Alveolar Bone Healing in Rats

Ibrahim,

Al-Hmedat,

Alsunboli

2024

TODENTJ

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Background Reproving dental defects is still a significant problem in dentistry. Bone is a highly vascularized tissue that is reliant on maintaining skeletal structure. The medicinal properties of healthy and preventative herbs were recognized by both the ancient and modern pharmacists and doctors in medicine. The effects of Myrtus communis oil (M) are employed as a healing agent for bone loss with anti-inflammatory and antioxidant properties. The advantage of Myrtus communis oil (M) is that it is a form of osteoconduction in the process of bone healing, decreases pain, and decreases the length of time needed for bone healing. Aim: to identify the effectiveness of Myrtus communis oil's local application in healing bone defects; the author performed a histological analysis. Materials and Methods This study involved 12 albino male rats weighing (300-400) grams, aged (6-8) months. The animals were subject to a surgical operation on the alveolar bone. The group of animals was divided into two distinct categories based on the applicable materials. Control group: 6 rats; bone defect was only washed by normal saline, and bone defect was left to heal normally. Myrtus communis group: 6 rats; bone defect treated by local application of 1 μl of Myrtus communis oil (M). The rats were sacrificed 7 and 14 days after surgery (six rats for each period). All bone sections stained with hematoxylin and eosin underwent a light microscope histological inspection, which included counting the number of bone cells (osteoblasts, osteocytes, and osteoclasts) and evaluating the results of histomorphometric analysis. Results Histological and histomorphometric findings of the present study show the acceleration of bone defect healing process in the Myrtus communis group as the increase in mean count difference measured of osteoblast, osteocyte, and osteoclast with statistically significant in 7 days duration. The result shows the positive expression of osteoblast, osteocyte, and osteoclast in all groups, with the highest statistical difference in osteocyte mean number in the Myrtus communis group. Conclusion Myrtus communis oil (M) has the potential to promote and be an effective therapeutic for the bone injury healing process.

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Metronidazole Potentiation by Panax Ginseng and Symphytum officinale: A New Strategy for P. gingivalis Infection Control

Cited by 3 publications

References 31 publications

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

Comparison of the Antibacterial Activity of Panax Ginseng and Symphytum Officinale with Metronidazole against P. gingivalis: An MIC and MBC Analysis

Histological Study to Evaluate the Effect of Local Application of Myrtus Communis Oil on Alveolar Bone Healing in Rats

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