Contribution of hippocampal region CA3 to consciousness and schizophrenic hallucinations

Behrendt, Ralf-Peter

doi:10.1016/j.neubiorev.2009.12.009

Cited by 69 publications

(64 citation statements)

References 155 publications

(222 reference statements)

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“…Top-down processing, on the other hand, is an active process that is driven by information from higher brain regions. It generates continuous predictions about the environment and actively integrates bottom-up information from the senses to test and further adjust these predictions (Behrendt, 2010;Freeman, 2003).…”

Section: Top-down Disturbances Of Perceptionmentioning

confidence: 99%

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Increased risk of psychosis in patients with hearing impairment: Review and meta-analyses

Linszen

Brouwer

Heringa

et al. 2016

Neuroscience & Biobehavioral Reviews

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Section: Top-down Disturbances Of Perceptionmentioning

confidence: 99%

“…Dysfunction in top-down processing may explain the presence of hallucinations (Behrendt, 2010;Hugdahl, 2009;de Ridder et al, 2014). Theoretically, erroneous top-down predictions about environmental stimuli can lead to false perceptions.…”

Section: Top-down Disturbances Of Perceptionmentioning

confidence: 99%

Increased risk of psychosis in patients with hearing impairment: Review and meta-analyses

Linszen

Brouwer

Heringa

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Information from the insular cortex reaches the anterior part of the hippocampus via the lateral entorhinal cortex, similarly to olfactory information and information processed by the perirhinal cortex (reviewed in Mohedano-Moriano et al, 2007). Emotional information from the agranular insula may thus be in a position to influence emotional aspects of event memory formation and maintain the subject's emotional experience of his or her situation, assuming that event memory formation and recall, including the formation and recall of emotional memories, are closely related to mechanisms that support conscious experience (Behrendt, 2010). Figure 1 The response to a situation may consist of random, exploratory or instrumental, goal-directed behavior.…”

Section: Anterior Insular Cortex Sustains Emotional Behaviormentioning

confidence: 99%

Situationally appropriate behavior: translating situations into appetitive behavior modes

Behrendt¹

2013

Reviews in the Neurosciences

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“…4 VH data are more cursory, although aberrant activity of the visual association areas and hippocampal complex may be involved. 5,6 At the molecular level, hallucinations during schizophrenia might result from increased dopaminergic (DAergic) transmission. 7 Since the 1970s, the mesolimbic pathway has been a proposed target of DAergic hyperactivity in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Resting-State Functional Connectivity of the Nucleus Accumbens in Auditory and Visual Hallucinations in Schizophrenia

Rolland¹,

Amad

Poulet

et al. 2014

Schizophrenia Bulletin

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Both auditory hallucinations (AH) and visual hallucinations may occur in schizophrenia. One of the main hypotheses underlying their occurrence involves the increased activity of the mesolimbic pathway, which links the ventral tegmental area (VTA) and the nucleus accumbens (NAcc). However, the precise contribution of the mesolimbic pathway in hallucinations across various sensory modalities has not yet been explored. We compared the resting-state functional connectivity (rs-FC) of the NAcc among 16 schizophrenia patients with pure AH, 15 with both visuoauditory hallucinations (VAH), and 14 without hallucinations (NoH). A betweengroup comparison was performed using random-effects ANCOVA (rs-FC of the bilateral NAcc as the dependent variable, groups as the between-subjects factor, age and Positive and Negative Syndrome Scale scores as covariates; q(false discovery rate [FDR]) < .05). Compared to the NoH group, the AH group exhibited significantly enhanced NAcc rs-FC with the left temporal superior gyrus, the cingulate gyri, and the VTA, whereas the VAH group, compared to the AH group, exhibited significantly enhanced NAcc rs-FC with the bilateral insula, putamen, parahippocampal gyri, and VTA. The strength in rs-FC between the NAcc and the VTA appeared to be positively associated with the presence of hallucinations, but the NAcc FC patterns changed with the complexity of these experiences (ie, 0, 1, or 2 sensory modalities), rather than with severity. This might support the aberrant salience hypothesis of schizophrenia. Moreover, these findings suggest that future clinical and neurobiological studies of hallucinations should evaluate not only the global severity of symptoms but also their sensorial features.

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Contribution of hippocampal region CA3 to consciousness and schizophrenic hallucinations

Cited by 69 publications

References 155 publications

Increased risk of psychosis in patients with hearing impairment: Review and meta-analyses

Increased risk of psychosis in patients with hearing impairment: Review and meta-analyses

Situationally appropriate behavior: translating situations into appetitive behavior modes

Resting-State Functional Connectivity of the Nucleus Accumbens in Auditory and Visual Hallucinations in Schizophrenia

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