Contribution of glycoproteins to fibrinogen-induced aggregation of erythrocytes

Maeda, Nobuji; Seike, Masahiko; Nakajima, Takashi; Izumida, Yoji; Sekiya, Misuzu; Shiga, Tohru

doi:10.1016/0005-2736(90)90401-9

Cited by 23 publications

(11 citation statements)

References 34 publications

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“…Likely the contribution of the bridging force of fibrinogen to the eryth rocyte aggregation could be much greater than electrostatic repulsive force produced by sialic acid on the surface of erythrocyte. This possi-bilty was on line with results obtained by Maeda et al (14,30) who have observed that the bridging force of macromolecules between adja cent erythrocytes (i.e. aggregating force) is greatly altered by structural change of surface glycoproteins, independently of ESAC.…”

Section: Discussionsupporting

confidence: 90%

Influence of Sialic Acid on Erythrocyte Aggregation in Hypercholesterolemi

Hadengue

Razavian²,

Del-Pino

et al. 1996

Thromb Haemost

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SummaryThe respective role of adhesive forces induced by fibrinogen and repulsive forces induced by erythrocyte sialic acid content on erythrocyte aggregation, was investigated in hypercholesterolemic and control subjects. Aggregation index (AI) and disaggregation shear rate threshold (³t) were determined in the presence of either autologous plasma or dextran. Compared with controls, fibrinogen (p <0.001) and aggregation parameters (AI p <0.01; ³t p <0.01) were higher in hypercholester-olemics while erythrocyte sialic acid content (p <0.001) was lower; in addition total serum sialic acid was increased (p <0.01). The aggregation properties of erythrocytes, independent of plasma environment using dextran as a bridging macromolecule, showed an enhanced disaggregation shear rate threshold and an inverse relationship with erythrocyte sialic acid content. We conclude that decreased erythrocyte sialic acid content may intensify the effect of fibrinogen on aggregation and disaggregation of erythrocytes and participate in the development of atherothrombotic complications.

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Section: Discussionsupporting

confidence: 90%

Influence of Sialic Acid on Erythrocyte Aggregation in Hypercholesterolemi

Hadengue

Razavian²,

Del-Pino

et al. 1996

Thromb Haemost

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“…Increased plasma fibrinogen concentration is believed to increase RBC aggregation. Fibrinogen affects all aspects of RBC aggregation such as aggregate size, stress, viscosity of red cell suspensions and RBC sedimentation [ 23 – 25 ]. It is believed that the recovery time between weigh-in and competition represents a key factor determining the performance during competition after RWR.…”

Section: Introductionmentioning

confidence: 99%

Rapid weight reduction does not impair athletic performance of Taekwondo athletes – A pilot study

Yang

Heine²,

Grau

2018

PLoS ONE

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In combat sports such as taekwondo (TKD), athletes rapidly reduce body weight to achieve a desired weight category. Competition takes place 16–24 h after weigh-in and thus, the recovery time is an important factor for competition performance. The purpose of this study was to investigate the impact of rapid weight reduction (RWR) on athletic performance and associated hemorheological properties considering relevant recovery time. Five male TKD athletes reduced body weight by 5% within 3½ days. A simulated competition day (SCD) was carried out after a 16 h recovery period. Parameters were measured before RWR, at weigh-in and before and after three TKD simulation matches (SMs) at SCD. Same set-up was conducted but without RWR as control. Basal blood parameters, red blood cells (RBC) deformability and aggregation, serum glucose and fibrinogen were determined. During SMs, heart rate (HRpeak, HRmean), oxygen uptake (VO2peak, VO2mean), peak lactate (Peak La-), difference of lactate (ΔLa) and energy systems (anaerobic-alactic, -lactic and aerobic) were analyzed. Basal blood parameters remained unaltered during the interventions. RBC deformability was reduced and aggregation was increased after RWR but values returned to baseline after recovery and were not affected by the SMs. Glucose level was not affected by the interventions. Kick frequency in SMs was higher after RWR which might be responsible for higher HRpeak, VO2peak, VO2mean, Peak La-, ΔLa- and aerobic demand. The 16 h recovery is sufficient to regenerate measured physiological and hemorheological parameters. TKD-specific performance was not negatively affected during SMs after RWR.

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“…Fibrinogen is generally accepted as the plasma protein that most contributes towards causing aggregation. With a physiological plasma concentration of ~150-300 mg/dl, fibrinogen is an acute phase protein whose concentration is enhanced during several cardiovascular diseases or inflammation [29]. As a result, fibrinogen has been shown to affect essentially all aspects of RBC aggregation from the size of aggregates to the viscosity of aggregated suspensions [30].…”

Section: Factors Affecting Rbc Aggregationmentioning

confidence: 99%

Photoacoustic Detection of Red Blood Cell Aggregation

Hysi¹

2021

Preprint

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The potential of photoacoustic imaging for detecting red blood cell (RBC) aggregation is explored. Enhanced aggregation is observed in disorders such as diabetes impairing oxygen release into tissue. Simultaneous measurements of aggregation and oxygenation levels cannot be made using current tools. Photoacoustic detection of aggregation and assessment of oxygen saturation was investigated. A theoretical and experimental model of aggregation was developed using human and porcine RBCs. Frequency-domain analysis of the PA signals was used to derive the spectral slope and midband fit of the normalized power spectra for various hematorit and aggregation conditions. Oxygen saturation was assessed using multiple wavelengths of illumination. The experimental spectral slope (~0.3 dB/MHz) for non-aggregated samples agreed with the theory decreasing with increasing aggregate size. The midband fit increased by ~5 dB when the aggregate size reached the largest level while the oxygen saturation increased by > 20%. These results suggest that photoacoustic-radio-frequency-spectroscopic-parameters have the potential to monitor RBC aggregation and oxygenation level.

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Contribution of glycoproteins to fibrinogen-induced aggregation of erythrocytes

Cited by 23 publications

References 34 publications

Influence of Sialic Acid on Erythrocyte Aggregation in Hypercholesterolemi

Influence of Sialic Acid on Erythrocyte Aggregation in Hypercholesterolemi

Rapid weight reduction does not impair athletic performance of Taekwondo athletes – A pilot study

Photoacoustic Detection of Red Blood Cell Aggregation

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