Influence of Sialic Acid on Erythrocyte Aggregation in Hypercholesterolemi

Hadengue, A.; Razavian, S.M.; Del-Pino, Muriel; Simon, A.; Levenson, Jaime

doi:10.1055/s-0038-1650690

Cited by 24 publications

(22 citation statements)

References 27 publications

(36 reference statements)

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“…18 Moreover, in the present work, we observed that the high variance of membrane sialic acid content, beginning even in young erythrocytes, was mainly explained by the levels of triglycerides and LDL cholesterol. Triglycerides may be involved in the decrease of membrane sialic acid content by an inhibition of sialyltransferase activity, the enzyme responsible for the transfer of NANA residues on the glycoproteins.…”

Section: Hadengue Et Al August 1998supporting

confidence: 62%

“…16,17 Furthermore, in a recent study we observed a diminished erythrocyte sialic acid content modulated by triglycerides and fibrinogen in hypercholesterolemic subjects, which might intensify the effect of fibrinogen on aggregation and disaggregation of erythrocytes and therefore contribute to the development of atherothrombotic complications. 18 To our knowledge, the relation between cell age-dependent changes in sialic acid content and erythrocyte aggregation has not been extensively studied in subjects with cardiovascular risk factors. The purpose of this investigation was to examine the impact of sialic acid content of erythrocytes related to in vivo aging on the aggregation process in essential hypertension with or without primary hypercholesterolemia.…”

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confidence: 99%

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Erythrocyte Disaggregation Shear Stress, Sialic Acid, and Cell Aging in Humans

et al. 1998

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Abstract-Erythrocyte aggregation, which plays an important role in the physiological behavior of blood fluidity, was found to be enhanced in hypertension and hypercholesterolemia. While the role of macromolecule bridging force has been widely described, cellular factors related to membrane sialic acid content, which might contribute to the negative charge of cell surface causing the repulsion of erythrocytes, have been less studied. Cell age-dependent changes in membrane sialic acid content (in micromoles per gram of integral membrane protein) were investigated in 24 normotensive and 24 hypertensive matched subjects, each divided into 2 identical subgroups according to a cutoff of 6.2 mmol/L serum cholesterol. A progressive and significant (PϽ0.001) decrease in membrane sialic acid content associated with an increase (PϽ0.001) of disaggregation shear rate threshold (laser reflectometry in the presence of dextran) were observed with increased erythrocyte density (erythrocytes fractionated by density using ultracentrifugation) in both normotensive and hypertensive groups regardless of the cholesterol level. However, disaggregation shear rate threshold was significantly higher and sialic acid content was lower (PϽ0.001) in both hypertensive and normotensive subjects with hypercholesterolemia compared with either normotensive or hypertensive subjects with low cholesterol, respectively. A high membrane sialic acid content variance, beginning in the younger erythrocytes, was due mainly to triglyceride and LDL cholesterol levels (R 2 ϭ0.49 for low, R 2 ϭ0.43 for middle, and R 2 ϭ0.54 for high densities, ie, young, mean, and senescent erythrocytes, respectively). We conclude that an early decrease in erythrocyte sialic acid content may influence the rheological properties of blood by increasing the adhesive energy of erythrocyte aggregates. (Hypertension. 1998;32:324-330.) Key Words: erythrocyte aggregation Ⅲ rheology Ⅲ sialic acid Ⅲ hypertension, essential Ⅲ hypercholesterolemia E rythrocyte aggregation is one of the main determinants influencing blood circulation at low shear rates by increasing blood viscosity and inducing "sludging" in the capillary.1 Aggregation of red blood cells is a reversible process that occurs when the bridging force due to the adsorption of macromolecules onto adjacent cell surfaces exceeds the disaggregation forces caused by electrostatic repulsion, membrane strain, and mechanical shearing. [1][2][3] An increase in erythrocyte aggregation was found to be associated with cardiovascular risk factors such as hypertension, 4 hyperlipoproteinemia, 5,6 and smoking 7 and in clinical situations such as myocardial ischemia, 8 thromboembolic states, 9 and retinal venous occlusion. 10 In general, most studies have focused on the ability of plasma proteins and various polymers to induce erythrocyte aggregation. We showed that in hypertension and hypercholesterolemia the increase in erythrocyte aggregation could be attributed to an increase in the concentration of plasma fibrinogen. 4,6 In addition, in ...

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Section: Hadengue Et Al August 1998supporting

confidence: 62%

mentioning

confidence: 99%

Erythrocyte Disaggregation Shear Stress, Sialic Acid, and Cell Aging in Humans

et al. 1998

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“…Venerando et al (83) have shown difference in expression of two sialidase forms (acidic and neutral) in diabetics' erythrocytes. It has also been suggested that decreased erythrocyte sialic acid content may intensify the effect of fibrinogen on aggregation and disaggregation of erythrocytes and participate in the development of atherothrombotic complications (13).…”

Section: Erythrocyte Sialic Acidmentioning

confidence: 99%

“…Thereafter, many studies showed that serum sialic acid were elevated in cardiovascular disease (3 -11). The sialic acid content of platelet, erythrocyte (RBC) and low density lipoprotein (LDL) has also been shown to play important role in the development of atherosclerotic complications (12,13,14). This review gives an account of the role played by sialic acid in cardiovascular diseases and highlights the areas where more studies are needed to establish the relevance of this biochemical parameter as a cardiovascular risk factor / marker.…”

Section: Introductionmentioning

confidence: 99%

Sialic acid in cardiovascular diseases

Nigam

Narain

Kumar

2006

Indian J Clin Biochem

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Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence more studies are needed to designate sialic acid as a cardiovascular risk factor / marker.

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“…According to Bastida and colleagues, asialo von Willebrand factor enhances platelet adhesion to vessel subendothelium [7]. Hadengue and colleagues found an inverse association between serum SA level and erythrocyte membrane SA content [8]. They concluded that decreased erythrocyte membrane SA content might participate in the development of atherotrombotic complications.…”

Section: Introductionmentioning

confidence: 99%

Resialylation of sialic acid deficit vascular endothelium, circulating cells and macromolecules may counteract the development of atherosclerosis: A hypothesis

Lindberg

2007

Atherosclerosis

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Influence of Sialic Acid on Erythrocyte Aggregation in Hypercholesterolemi

Cited by 24 publications

References 27 publications

Erythrocyte Disaggregation Shear Stress, Sialic Acid, and Cell Aging in Humans

Erythrocyte Disaggregation Shear Stress, Sialic Acid, and Cell Aging in Humans

Sialic acid in cardiovascular diseases

Resialylation of sialic acid deficit vascular endothelium, circulating cells and macromolecules may counteract the development of atherosclerosis: A hypothesis

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