Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril

Elsayed, Laila; Osama, Eman; Mehesen, Marwa Nagi; Rashed, Laila Ahmed; Aboulkhair, Alshaymaa Gamal; Omar, Abeer Ibraheem; Eldeen, Asmaa M Shams

doi:10.1016/j.pupt.2020.101888

Cited by 7 publications

(10 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lungs are among the organs most affected by distant organ damage during I/R (24)(25). Perivascular and peribronchial edema, increases in alveolar wall thickness, and leukocyte infiltration have been observed in lung tissues after hepatic I/R (26). Similarly, another study reported that necrosis, inflammatory cells, bleeding, and microsteatosis significantly increased in the lungs after hepatic I/R injury (27).…”

Section: Discussionmentioning

confidence: 97%

Sıçanlarda Hepatik İskemi Reperfüzyon Hasarında Farklı Dozlarda Amantadin'in Akciğer Dokusu Üzerine Etkisi

Şahin

Orhan

Tuna

et al. 2022

Konuralp Tıp Dergisi

View full text Add to dashboard Cite

Objective: N-Methyl D-Aspartate (NMDA) receptor blockers have been shown to have protective effects against ischemia/reperfusion (I/R) injury in various tissues. The aim of this study was to investigate the effects of 90 ve 135 mg/kg doses of amantadine on lung in hepatic I/R injury. Method: The rats were randomly divided into six groups: Group Sham, Group I/R, Group Amantadine-90, Group Amantadine-135, Group I/R-90 and Group I/R-135. In I/R, an atraumatic vascular clamp was applied to the structures in the left portal triad for 45 minutes and reperfusion period was 2 hours after ischemia. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) enzyme levels were performed the lung tissue and tissues were examined histopathologically. Result: A significant difference was found between the groups in terms of MDA, SOD, CAT levels (respectively; p < 0.001, p=0.008, p < 0.001). A significant difference was found between the groups in terms of lung tissue neutrophil/lymphocyte infiltration scores and alveolar wall thickening scores (respectively p=0.009, p=0.002). Conclusion: The biochemical and histopathological results of the present study suggested that amantadine, like other NMDA antagonist agents, may have a protective effect on lung tissues against the damage caused by hepatic I/R injury. Although we observed significant improvements after the administration of both doses studied, there was no significant difference between these two doses in terms of their success in protecting against distant organ lung injury. Amantadine appears promising as a therapeutic agent in treatment.

show abstract

Section: Discussionmentioning

confidence: 97%

Sıçanlarda Hepatik İskemi Reperfüzyon Hasarında Farklı Dozlarda Amantadin'in Akciğer Dokusu Üzerine Etkisi

Şahin

Orhan

Tuna

et al. 2022

Konuralp Tıp Dergisi

View full text Add to dashboard Cite

show abstract

“…Captopril has been reported to decrease the level of TNFα [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ], reduce alveolar wall thickening and neutrophil infiltration in rats with induced acute lung injury [ 33 ]. Our research supports the results of other studies on the reduction of TNFα by ACEI.…”

Section: Discussionmentioning

confidence: 99%

“…Captopril reduced the concentration of the highly sensitive C-reactive protein (hs-CRP) [ 12 , 28 , 32 ]. Treatment with a high dose of captopril significantly reduced the number of Kupffer cells (liver macrophages) in the model of hepatic ischemia/reperfusion (I/R) injury in rats [ 13 ]. Captopril decreased the concentration of IL-1 beta and IL-6 in the different inflammatory rat models of renal hypertension, hepatic injury, myocarditis [ 11 , 12 , 35 , 41 ] as well as IL-8 reduction of human coronary artery endothelial cells [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activities of Captopril and Diuretics on Macrophage Activity in Mouse Humoral Immune Response

Bryniarski

Nazimek

Marcinkiewicz

2021

IJMS

View full text Add to dashboard Cite

Hypertension is accompanied by the over-activation of macrophages. Diuretics administered alone or in combination with hypotensive drugs may have immunomodulatory effects. Thus, the influence of tested drugs on mouse macrophage-mediated humoral immunity was investigated. Mice were treated intraperitoneally with captopril (5 mg/kg) with or without hydrochlorothiazide (10 mg/kg) or furosemide (5 mg/kg) by 8 days. Mineral oil-induced peritoneal macrophages were harvested to assess the generation of cytokines in ELISA, and the expression of surface markers was analyzed cytometrically. Macrophages were also pulsed with sheep red blood cells (SRBC) and transferred to naive mice for evaluation of their ability to induce a humoral immune response. Tested drugs increase the expression of surface markers important for the antigen phagocytosis and presentation. SRBC-pulsed macrophages from mice treated with captopril combined with diuretics increased the secretion of antigen-specific antibodies by recipient B cells, while macrophages of mice treated with hydrochlorothiazide or furosemide with captopril increased the number of antigen-specific B cells. Tested drugs alter the macrophage secretory profile in favor of anti-inflammatory cytokines. Our results showed that diuretics with or without captopril modulate the humoral response by affecting the function of macrophages, which has significant translational potential in assessing the safety of antihypertensive therapy.

show abstract

“…Plasminogen activator inhibitor (PAI)-1 is a biomarker of ARDS ( Bhargava and Wendt, 2012 ) and was increased in conjunction with Ang II in a rat model of VILI ( Chen et al, 2008 ). Systemic PAI-1 levels and VILI were attenuated by treatment with the ACE inhibitor captopril, and, interestingly, also hepatic ischemia/reperfusion-induced lung injury in rats was ameliorated by treatment with captopril ( El-Sayed et al, 2020 ).…”

Section: Experimental Evidence About the Role Of The Renin-angiotensi...mentioning

confidence: 99%

The Renin-Angiotensin System as a Component of Biotrauma in Acute Respiratory Distress Syndrome

et al. 2022

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) is a major concern in critical care medicine with a high mortality of over 30%. Injury to the lungs is caused not only by underlying pathological conditions such as pneumonia, sepsis, or trauma, but also by ventilator-induced lung injury (VILI) resulting from high positive pressure levels and a high inspiratory oxygen fraction. Apart from mechanical factors that stress the lungs with a specific physical power and cause volutrauma and barotrauma, it is increasingly recognized that lung injury is further aggravated by biological mediators. The COVID-19 pandemic has led to increased interest in the role of the renin-angiotensin system (RAS) in the context of ARDS, as the RAS enzyme angiotensin-converting enzyme 2 serves as the primary cell entry receptor for severe acute respiratory syndrome (SARS) coronavirus (CoV)-2. Even before this pandemic, studies have documented the involvement of the RAS in VILI and its dysregulation in clinical ARDS. In recent years, analytical tools for RAS investigation have made major advances based on the optimized precision and detail of mass spectrometry. Given that many clinical trials with pharmacological interventions in ARDS were negative, RAS-modifying drugs may represent an interesting starting point for novel therapeutic approaches. Results from animal models have highlighted the potential of RAS-modifying drugs to prevent VILI or treat ARDS. While these drugs have beneficial pulmonary effects, the best targets and application forms for intervention still have to be determined to avoid negative effects on the circulation in clinical settings.

show abstract

Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril

Cited by 7 publications

References 47 publications

Sıçanlarda Hepatik İskemi Reperfüzyon Hasarında Farklı Dozlarda Amantadin'in Akciğer Dokusu Üzerine Etkisi

Sıçanlarda Hepatik İskemi Reperfüzyon Hasarında Farklı Dozlarda Amantadin'in Akciğer Dokusu Üzerine Etkisi

Anti-Inflammatory Activities of Captopril and Diuretics on Macrophage Activity in Mouse Humoral Immune Response

The Renin-Angiotensin System as a Component of Biotrauma in Acute Respiratory Distress Syndrome

Contact Info

Product

Resources

About