Contrast Sensitivity after Pars Plana Vitrectomy: Comparison between Macula-On and Macula-Off Rhegmatogenous Retinal Detachment

Kawamura, Hajime; Fujikawa, Masato; Sawada, Osamu; Sawada, Tomoko; Saishin, Yoshitsugu; Ohji, Masahito

doi:10.1159/000445210

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…27 The reduced thickness does not worsen throughout follow-up at 1 or more than 2 years. It could be the consequence of macular detachment as observed in detachments of macula-off retina, which have a worse visual prognosis than macula-on retina, 28,29 which appears correlated to whether or not there is an intact EZ line post-operatively. 30 However, we observed no alterations in total macular retinal thickness at either 1 or 2+ years post-injection, in contrast to the findings of both Bainbridge et al 12 and Jacobson et al, 13 who attributed the progressive decrease in retinal thickness to the pursuit of retinal degeneration.…”

Section: Discussionmentioning

confidence: 99%

Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis

et al. 2018

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The aim of this study was the evaluation of the safety and efficacy of unilateral subretinal injection of the adeno-associated vector (AAV) serotypes 2 and 4 (AAV2/4) RPE65-RPE65 vector in patients with Leber congenital amaurosis (LCA) associated with RPE65 gene deficiency. We evaluated ocular and general tolerance and visual function up to 1 year after vector administration in the most severely affected eye in nine patients with retinal degeneration associated with mutations in the RPE65 gene. Patients received either low (1.22 × 10 to 2 × 10 vector genomes [vg]) or high (between 3.27 × 10 and 4.8 × 10 vg) vector doses. An ancillary study, in which six of the original nine patients participated, extended the follow-up period to 2-3.5 years. All patients showed good ophthalmological and general tolerance to the rAAV2/4-RPE65-RPE65 vector. We observed a trend toward improved visual acuity in patients with nystagmus, stabilization and improvement of the visual field, and cortical activation along visual pathways during fMRI analysis. OCT analysis after vector administration revealed no retinal thinning, except in cases of macular detachment. Our findings show that the rAAV2/4.RPE65.RPE65 vector was well tolerated in nine patients with RPE65-associated LCA. Efficacy parameters varied between patients during follow-up.

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Section: Discussionmentioning

confidence: 99%

Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis

et al. 2018

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“…Several studies have reported that CS worsened after ocular surgeries, such as laser in situ keratomileusis and macula-on rhegmatogenous retinal detachment, which might be due to decreased central VA after surgery 16 , 21 , 22 . However, even patients with good postoperative VA have decreased CS, and this could possibly be due to factors other than VA such as surgical stress and visual discomfort 23 . CS is temporarily decreased after refractive surgeries but is recovered after 3 months 16 .…”

Section: Discussionmentioning

confidence: 99%

Changes in contrast sensitivity after surgery for intermittent exotropia

Bae

Choi

2022

Sci Rep

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To determine whether intermittent exotropia (IXT) surgery affects contrast sensitivity (CS), this retrospective study evaluated the changes in monocular and binocular CS and the binocular summation ratio (BSR) quantified as the ratio between the values of the binocular and the better monocular CS score (BSR = binocular CS score/better monocular CS score) after surgery for IXT. The subjects were patients who had undergone IXT-correcting surgery with a postoperative follow-up of > 3 months and had pre- and postoperative records of Mars CS test scores. In total, 64 patients (128 eyes) were evaluated. Both the binocular and monocular CS scores of the operated eyes were significantly worse on postoperative 1 day than the preoperative scores, but they were recovered after 1 week. The monocular CS scores of the operated eyes were significantly worse than those of the non-operated eyes until 1 week. There was no significant difference in monocular CS scores between the one-muscle and two-muscle surgeries and in binocular CS scores between the successful alignment and overcorrection groups even on the first day after surgery. The mean BSR was significantly decreased until postoperative month 1, however, recovered to preoperative levels after month 3. In conclusion, IXT-correcting surgery may temporarily worsen the CS, but it is recovered to preoperative levels. Thus, changes in CS in the immediate postoperative period after strabismus surgery should not be of concern.

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“…[36][37][38] Using the 25-item National Eye Institute Visual Function Questionnaire in patients with RRD, 39 Okamoto et al reported vision-related quality of life to be significantly correlated with postoperative CS measured by preprinted letter charts, yet no correlation was found between vision-related quality of life and postoperative VA. 40 Several previous reports have shown reduced CS in patients with RRD using preprinted letter charts. [41][42][43] Despite measuring CS using methods with poor range and resolution for sampling target contrast and frequency [28][29][30] and poor test-retest reliability, 29,31,32 those reports demonstrated the detrimental effect of RD on CS.…”

Section: Discussionmentioning

confidence: 99%

“…43 Kawamura et al demonstrated lower CS in 36 macula-off RRD eyes with a postoperative BCVA of greater than 1.0 compared with macula-on RRD eyes following surgery. 42 The latter group used a Takagi glare tester CGT-2000 to measure CS, which has been shown to have relatively poor accuracy and repeatability. 44 In clinical practice, a visual function metric more sensitive to subtle changes than VA would be particularly valuable in detecting subtle subjective visual impairment noted by the patient and subsequently better guide our clinical judgment on initiating and evaluating our therapeutic interventions.…”

Section: Discussionmentioning

confidence: 99%

Active Learning of Contrast Sensitivity to Assess Visual Function in Macula-Off Retinal Detachment

Thomas

Silverman

Vingopoulos

et al. 2020

Journal of VitreoRetinal Diseases

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Purpose: This work characterizes the contrast sensitivity function (CSF) in patients with successful repair of macula-off rhegmatogenous retinal detachment (RD) using an adaptive computerized contrast testing device. Methods: CSF was prospectively measured in patients with macula-off RD following successful repair and age-matched controls at W.K. Kellogg Eye Center and Massachusetts Eye and Ear using Adaptive Sensory Technology’s Manifold Contrast Vision Meter. Outcome measures included average area under the CSF curve, contrast-sensitivity thresholds (1-18 cycles per degree), and best-corrected visual acuity (BCVA) in RD eyes, fellow eyes, and controls. A subanalysis was performed in eyes with BCVA of 20/30 or better. Results: Twenty-three macula-off RD eyes following repair, fellow healthy eyes, and 45 age-matched control eyes underwent CSF testing. Mean BCVA of the 23 RD eyes was 0.250 logMAR, which was, significantly reduced compared with fellow eyes 0.032 ( P < .001) and controls 0.026 ( P < .001). There was a statistically significant reduction in average area under the CSF curve in RD eyes compared with fellow eyes ( P < .0001) and age-matched controls ( z score –0.90, P < .0001) and CSF reduction across all spatial frequencies. In the 15 RD eyes with BCVA of 20/30 or better, the mean CSF was significantly reduced vs fellow eyes ( P = .02) and controls ( P = .045). Conclusions: CSF in macula-off RD eyes following repair was significantly reduced compared with fellow eyes and age-matched controls. CSF may be a promising visual function end point with applications in clinical practice and future clinical trials.

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Contrast Sensitivity after Pars Plana Vitrectomy: Comparison between Macula-On and Macula-Off Rhegmatogenous Retinal Detachment

Cited by 10 publications

References 8 publications

Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis

Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis

Changes in contrast sensitivity after surgery for intermittent exotropia

Active Learning of Contrast Sensitivity to Assess Visual Function in Macula-Off Retinal Detachment

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