Contrast Media Adversely Affect Oxyhemoglobin Dissociation

Association of Admission Hemoglobin Levels and Acute Kidney Injury Among Myocardial Infarction Patients Treated With Primary Percutaneous Intervention

“…Contrast media could increase oxygen affinity of hemoglobin, so oxygen delivery to the peripheral tissues might be impaired. 25 Local renal hypoxia can therefore be aggravated among patients with low hemoglobin levels after exposure to contrast media; hence, the combination of contrast-induced vasoconstriction and anemia might decrease oxygen delivery, sufficiently to cause renal medullary hypoxia. Previous studies have shown that anemia increases the risk of CIN in various patient populations.…”

Outcome Differences between Intra-Arterial Iso- and Low-Osmolality Iodinated Radiographic Contrast Media in the Interventional Management of Stroke III Trial

“…IRCM have been reported to adversely affect oxyhemoglobin dissociation. 85 Decreased pH or increased temperature in the hypoxic brain tissue can cause changes in the physicochemical properties of IRCM as well. Increased BBB disruption has been demonstrated in rabbits with IA injection of higher iodine-concentration IRCM (300 versus 150 mg/mL), at a lower temperature (24°C versus 37°C), during a briefer time (1 versus 30 seconds).…”

Decreased Infarct Volume and Intracranial Hemorrhage Associated with Intra-Arterial Nonionic Iso-Osmolar Contrast Material in an MCA Occlusion/Reperfusion Model

“…Even in the absence of coagulation-mediated oligemic effects, increased hemoglobin binding attributed to IRCM may exert a circulatory hypoxic effect, promoting neurotoxicity via reduced oxygen delivery to tissue. 38 Physical properties such as viscosity differ among IRCM and can exert a hydrostatic effect. 39 Iodixanol has increased viscosity (11.8 cP)…”