Contrast-Induced Nephropathy (CIN) and Biomarkers

Georgiadis, Georgios; Docea, Anca Oana; Calina, Daniela; Tsatsakis, Aristidis; Mamoulakis, Charalampos

doi:10.1007/978-3-030-87225-0_56-1

Cited by 1 publication

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“…14 CIN management remains supportive based mainly on intravenous hydration in high-risk patients, using saline or bicarbonate. 15 Novel biomarkers 16,17 and agents with antioxidant and vasodilatory properties are attracting attention due to their ability to reduce oxidative stress/regulate vascular tone. 3,4,[18][19][20] The potential renoprotective effects of several antioxidants have been evaluated but none of them has been proven effective in human studies.…”

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confidence: 99%

Resveratrol and lycopene ameliorate contrast-induced nephropathy in a rabbit model

et al. 2022

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Oxidative stress appears to possess a central role in CIN pathophysiology. Resveratrol (Res) and lycopene (Lyc) are strong natural antioxidants evaluated in a limited number of CIN animal studies in vivo. The aim of the study was to evaluate the potential renoprotective effects of Res/Lyc in a CIN rabbit model. Twenty-four adult male New Zealand white rabbits were equally assigned into four groups: control (saline), CIN (intravenous iopromide; 7.5 g iodine/kg), Res + CIN (per os Res; 5 mg/kg), and Lyc + CIN (per os Lyc; 4 mg/kg). Serum Cr (sCr); symmetric/asymmetric dimethylarginine (SDMA/ADMA); oxidative stress biomarkers: malondialdehyde; total antioxidant capacity; catalase; glutathione) were evaluated in blood samples at three time points: right after (0 h); 24 h; 48 h after iopromide/saline administration. CD20+/CD3+ lymphocytes were determined (48 h). All animals were sacrificed at 48 h and both kidneys collected. Oxidative stress biomarkers were measured in renal tissue. sCr and SDMA/ADMA levels increased significantly in CIN compared to all groups. Oxidative stress secondary to CIN in blood/kidneys was suppressed by Res/Lyc. B and T lymphocytes decreased significantly in CIN compared to all groups. The present study provides emerging evidence that Res/Lyc ameliorate CIN by modulating oxidant/antioxidant balance in blood/renal tissue and by inhibiting vasoconstriction/blood cytotoxicity.

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