Contrast-induced nephropathy and bleeding: A bidirectional link with prognostic value in acute coronary syndrome

Raposeiras‐Roubín, Sergio; Abu-Assi, Emad; Ocaranza-Sánchez, Raymundo; Barreiro-Pardal, Cristina; Bouzas-Cruz, Noelia; Castiñeiras-Busto, María; López‐López, Andrea; Pereira-López, Eva; Gestal-Romarí, Santiago; Rodríguez-Cordero, Marta; Peña-Gil, Carlos; Garcı́a-Acuña, José Marı́a; González-Juanatey, José Ramón

doi:10.1016/j.ijcard.2014.06.071

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…12 Another study divided the bleeding into 2 parts, pre/pericatheter bleeding and postcatheter bleeding. 13 We used the TIMI classification to evaluate whether there was a relationship between bleeding and CIN. We found that TIMI bleeding was significantly higher in patients with CIN.…”

Section: Discussionmentioning

confidence: 99%

“…The MHR was calculated by dividing the monocyte count to the HDL-C level using the same blood samples obtained before PCI. 13 Baseline serum creatinine was measured at admission (before PCI) and on days 1, 2, and 3 after the procedure. The eGFR was calculated using the Modification of Diet in Renal Disease formula.…”

Section: Methodsmentioning

confidence: 99%

“…11 Few retrospective studies have investigated bleeding as a risk factor for CIN in the setting of ACS or elective PCI. 12,13 The thrombolysis in myocardial infarction (TIMI) bleeding classification is one of the most commonly used and reliable classifications in patients with ACS. As far as we know, the TIMI classification has not been used to assess whether there is a relationship between bleeding and CIN in such patients.…”

Section: Introductionmentioning

confidence: 99%

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Monocyte to High-Density Lipoprotein Ratio Predicts Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome

et al. 2018

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Contrast-induced nephropathy (CIN) is associated with worse prognosis in patients with acute coronary syndrome (ACS). Early identification and intervention for patients with a high risk of CIN are very important to improve clinical outcomes. Inflammation plays important role in the development of CIN in the setting of ACS. The monocyte to high-density lipoprotein ratio (MHR) is a novel inflammatory marker. Bleeding is also associated with worse prognosis in such patients. We aimed to investigate whether the preprocedural MHR had a predictive role for CIN development in such patients. In addition, using the thrombolysis in myocardial infarction classification, we aimed to assess whether there was any relationship between bleeding and CIN. A total of 647 patients (496 males; age: 63.3 ± 12.7 years) with ACS who underwent percutaneous coronary intervention (PCI) were included in the study. Seventy patients (10.8%) had developed CIN. Age, diabetes mellitus, contrast volume, estimated glomerular filtration rate, and MHR were independent predictors for CIN. Preprocedural MHR may be used as a simple marker of CIN. It may help with the early identification of patients with ACS who underwent PCI who are at high risk of CIN thus allowing the planning of protective measures.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%