Contrast-free MRA at 3.0 T for the detection of intracranial aneurysms

Li, M.-H.; Li, Y.-D.; Tan, Hua-Qiao; B, Gu; Chen, Y.-C.; Wang, W.; Chen, S.-W.; Hu, Dawei

doi:10.1212/wnl.0b013e3182299f5a

Cited by 60 publications

(46 citation statements)

References 34 publications

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“…8 The use of MRA also simulates the clinical setting whereby it is the most likely radiological investigation offered as a screening tool for asymptomatic individuals.…”

Section: Methodsmentioning

confidence: 99%

Screening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese

Chan¹,

Abrigo

Cheung

et al. 2016

JNS

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OBJECT The objective of this study was to generate data on the local prevalence of unruptured intracranial aneurysms (UIAs) in asymptomatic Hong Kong Chinese individuals. First-degree relatives of patients with aneurysmal subarachnoid hemorrhage (aSAH) were recruited as surrogates of the general population and to explore the potential role of screening in this locality. METHODS The authors identified first-degree relatives of consecutive patients with subarachnoid hemorrhage from a ruptured aneurysm who were admitted to a university hospital in Hong Kong from June 2008 to December 2010. Magnetic resonance angiography (MRA) was the imaging modality used to screen the cerebral vasculature of these asymptomatic individuals. If MRA showed abnormal findings, CT angiography was performed to confirm the MRA findings. RESULTS In total, 7 UIAs were identified from the 305 MR angiograms obtained. The prevalence of UIAs in first-degree relatives of patients with aSAH in the Hong Kong Chinese population was 2.30% (95% CI1.02%–4.76%). This percentage was lower than the prevalence rate of 3.2% from a meta-analysis of the literature. The sizes of the UIAs detected ranged from 1.4 mm to 7.5 mm; 85.7% of the UIAs detected in this study were < 5 mm, in contrast to 66% noted in the literature. One of the UIAs identified underwent endovascular stent placement with a flow diverter. None of the UIAs identified ruptured or became symptomatic during a median follow-up period of 3.5 years. CONCLUSIONS The prevalence of UIAs in first-degree relatives of patients with aSAH in the Hong Kong Chinese population was lower than that in Caucasians. At the same time, most of the UIAs detected in this study were small (85.7% were < 5 mm, vs 66% in a meta-analysis). With a similar incidence of aSAH in Hong Kong (7.5 per 100,000 person-years) as compared with data cited in the literature, the hypothesis that UIA rupture risk size threshold is different in Chinese patients should be further investigated.

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“…8 The use of MRA also simulates the clinical setting whereby it is the most likely radiological investigation offered as a screening tool for asymptomatic individuals.…”

Section: Methodsmentioning

confidence: 99%

Screening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese

Chan¹,

Abrigo

Cheung

et al. 2016

JNS

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“…2 Nevertheless, an increasing number of recent studies suggest that DSA is no longer considered essential for establishing the diagnosis of cerebral aneurysms, 3,4 particularly when 3T MR imaging scanners are used. 2,5,6 Despite the continuing sophistication of the imaging technique, 1 important cause of the limited sensitivity of MRA is the detection failures of radiologists. Interpretation of both source and reconstructed images is recommended to achieve good sensitivity of MRA, [7][8][9] but detecting relatively small lesions is a timeconsuming and difficult task.…”

mentioning

confidence: 99%

Computer-Assisted Detection of Cerebral Aneurysms in MR Angiography in a Routine Image-Reading Environment: Effects on Diagnosis by Radiologists

Miki¹,

Hayashi²,

Masutani

et al. 2016

AJNR Am J Neuroradiol

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“…The sensitivity of MRA for cerebral aneurysms is only between 55% and 99.2%, because with aneurysms 5 mm , the sensitivity is 85% to 100% and the sensitivity of MRA for detecting aneurysms <5 mm drops to 56% [21,22] . MRA has practical limitations in the characteristics of the aneurysm neck and its relationship to the parent vessels [1,23].…”

Section: Preoperative Planningmentioning

confidence: 99%

Ruptured Cerebral Aneurysms: An Update

Ming¹,

Zhao²,

Li³

et al. 2012

Explicative Cases of Controversial Issues in Neurosurgery

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Contrast-free MRA at 3.0 T for the detection of intracranial aneurysms

Abstract: VR 3D-TOF-MRA at 3.0 T accurately identified the presence of intracranial aneurysms. High PPV and NPV indicated that VR 3D-TOF-MRA at 3.0 T may replace DSA as a contrast-free, noninvasive, and non-radiation-based modality for the diagnosis and screening of intracranial aneurysms.

Cited by 60 publications

References 34 publications

Screening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese

Screening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese

Computer-Assisted Detection of Cerebral Aneurysms in MR Angiography in a Routine Image-Reading Environment: Effects on Diagnosis by Radiologists

Ruptured Cerebral Aneurysms: An Update

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