Contrast-enhanced ultrasound using real-time contrast harmonic imaging in invasive breast cancer: comparison of enhancement dynamics with three different doses of contrast agent

Saracco, Ariel; Szabó, Botond K.; Aspelin, Peter; Leifland, Karin; Tánczos, Ervin; Wilczek, Brigitte; Axelsson, Rimma

doi:10.1177/0284185114520860

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…A total of 2.4 mL of the contrast agent was used as an establish required dose for using a 9 MHz probe and due to our previous experience (12,14,15) and administrated manually as a bolus (2 s) followed by a flush of 10 cc saline solution. The examination was recorded in a contrast side/side imaging mode loop from the start of the bolus and for a 120-s period.…”

Section: Methodsmentioning

confidence: 99%

Contrast-enhanced ultrasound (CEUS) in assessing early response among patients with invasive breast cancer undergoing neoadjuvant chemotherapy

et al. 2016

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Background One of the big challenges in onco-radiology is to find a reliable imaging method that may predict early response during the first cycles of any neoadjuvant chemotherapy. Purpose To evaluate the use of real-time harmonic contrast-enhanced ultrasound (CEUS) in predicting early response in breast cancer tumors under neoadjuvant chemotherapy (NAC) treatment. Material and Methods Nineteen consecutive patients with invasive breast cancer were evaluated with a bolus dose of 2.4 mL contrast agent using CEUS, before and after two cycles of epirubicin and docetaxel. The lognormal function was used for quantitative analysis of kinetic data to evaluate early response. Results There was statistically significant difference in time-to-peak ( t) between responders and non-responders (two sample t-test, P = 0.027) where t was significantly longer at the week 5 than at the baseline scan among responders when compared to non-responders. Conclusion In-flow of intravascular contrast agent in tumors is significantly slower in responders at real-time harmonic CEUS, and might be effectively used for the evaluation of early response to chemotherapy in invasive breast cancer. However, further investigations in a larger and more heterogeneous population should be performed to corroborate the reliability of the method.

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Section: Methodsmentioning

confidence: 99%

Contrast-enhanced ultrasound (CEUS) in assessing early response among patients with invasive breast cancer undergoing neoadjuvant chemotherapy

et al. 2016

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“…However, the quantitative parameters are subject to considerable variations caused by factors such as scanner settings, microbubble type, handling, and administration, or physiological variations as reviewed by Tang et al and summed in the European guidelines for quantitative CEUS (168,169). Therefore, evaluation of the reproducibility of the quantitative outcomes is crucial to consider in the planning of future clinical studies (170,171).…”

Section: Contrast-enhanced Ultrasoundmentioning

confidence: 99%

Highlights of the development in ultrasound during the last 70 years: A historical review

et al. 2021

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This review looks at highlights of the development in ultrasound, ranging from interventional ultrasound and Doppler to the newest techniques like contrast-enhanced ultrasound and elastography, and gives reference to some of the valuable articles in Acta Radiologica. Ultrasound equipment is now available in any size and for any purpose, ranging from handheld devices to high-end devices, and the scientific societies include ultrasound professionals of all disciplines publishing guidelines and recommendations. Interventional ultrasound is expanding the field of use of ultrasound-guided interventions into nearly all specialties of medicine, from ultrasound guidance in minimally invasive robotic procedures to simple ultrasound-guided punctures performed by general practitioners. Each medical specialty is urged to define minimum requirements for equipment, education, training, and maintenance of skills, also for medical students. The clinical application of contrast-enhanced ultrasound and elastography is a topic often seen in current research settings.

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“…There was an interval of 10 min between the two examinations in every patient. 9 To eradicate contrast bubbles within the lesion, high-mechanical index (MI) waves were used during this interval. Every CEUS process was recorded for 180 s until no apparent contrast agent could be observed.…”

Section: Image Analysismentioning

confidence: 99%

“…We also found that transducers used for conventional breast ultrasound are different from transducers for breast CEUS. 9,10 The aim of this study was to compare the effectiveness of transducers with different frequencies in detecting local blood perfusion defects and surrounding vessels in the same breast lesions of the same patients. This study will assess the influence of different transducers on the detection outcomes of breast CEUS and try to find a way to improve the diagnostic efficacy of breast CEUS.…”

Section: Introductionmentioning

confidence: 99%

Comparison of transducers with different frequencies in breast contrast-enhanced ultrasound (CEUS) using SonoVue as contrast agent

Wang¹,

Fan²,

Zhang³

et al. 2016

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Contrast-enhanced ultrasound using real-time contrast harmonic imaging in invasive breast cancer: comparison of enhancement dynamics with three different doses of contrast agent

Abstract: The optimal way to evaluate kinetic features of invasive breast tumors using real-time CEUS is with an injection of contrast agent of either 2.4 mL or 4.8 mL.

Cited by 12 publications

References 20 publications

Contrast-enhanced ultrasound (CEUS) in assessing early response among patients with invasive breast cancer undergoing neoadjuvant chemotherapy

Contrast-enhanced ultrasound (CEUS) in assessing early response among patients with invasive breast cancer undergoing neoadjuvant chemotherapy

Highlights of the development in ultrasound during the last 70 years: A historical review

Comparison of transducers with different frequencies in breast contrast-enhanced ultrasound (CEUS) using SonoVue as contrast agent

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