Contrast-Enhanced Ultrasound Techniques for Guiding and Assessing Response to Locoregional Treatments for Hepatocellular Carcinoma

Andreana, Lorenzo; Kudo, Masatoshi; Hatanaka, Kinuyo; Chung, Hobyung; Minami, Yasunori; Maekawa, Kiyoshi; Ruggiero, Giuseppe

doi:10.1159/000315233

Cited by 13 publications

(8 citation statements)

References 107 publications

(276 reference statements)

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“…Previously, CECT or CEMRI has been regarded as the reference standard for treatment response evaluation after local therapies. Recently, several studies have proven that CEUS has the same ability to evaluate treatment response as CECT or CEMRI, thus CEUS can be performed as an alternative method to spare CECT or CEMRI for this purpose [8,[50][51][52][53] . CEUS, similar to CECT or CEMRI, also follows the guideline of the modified Response Evaluation Criteria in Solid Tumor (mRECIST) [54] .…”

Section: Ceus-guided Percutaneous Biopsy and Therapymentioning

confidence: 99%

Management of hepatocellular carcinoma: The role of contrast-enhanced ultrasound

Zheng

Liu

2014

WJR

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Hepatocellular carcinoma (HCC) is the sixth most common neoplasm and the third cause of cancer death worldwide. Contrast enhanced ultrasound (CEUS) has been applied for more than ten years and plays increasingly important roles in the management of HCC. On the basis of the Guideline and Good Clinical Practice Recommendations for CEUS in the liver-update 2012 and related literature about the management of HCC, we summarize the main roles and applications of CEUS in the management of HCC, including HCC surveillance, diagnosis, CEUS-guided treatment, treatment response evaluation and follow-up. The diagnostic algorithm for HCC is also suggested. Meanwhile, the comparisons between CEUS and contrast enhanced computed tomography/magnetic resonance imaging (CECT/CEMRI) in these areas are made. Although CEUS is subject to the same limitation as ordinary US and is inferior to CECT/CEMRI in some aspects, CEUS has proved to be of great value in the management of HCC with inherent advantages, such as sufficient high safety profile making it suitable for patients with renal failure or allergic to iodine, absence of radiation, easy reproducibility and high temporal resolution. The tremendous application of CEUS to the diagnosis and treatment of HCC provides more opportunities for patients with HCC diagnosed at different stages.

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Section: Ceus-guided Percutaneous Biopsy and Therapymentioning

confidence: 99%

Management of hepatocellular carcinoma: The role of contrast-enhanced ultrasound

Zheng

Liu

2014

WJR

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“…In addition to the diagnosis of FLLs, CEUS can be used in the primary guidance and assessment of treatment responses in US-guided interventions such as liver biopsy or percutaneous local ablative treatment of both HCCs and metastases 82. CEUS is exceptionally useful due to its ability to visualize the target lesion when it is poorly delineated in B-mode grayscale US and CT guidance is not available 83.…”

Section: Introductionmentioning

confidence: 99%

Current consensus and guidelines of contrast enhanced ultrasound for the characterization of focal liver lesions

et al. 2013

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The application of ultrasound contrast agents (UCAs) is considered essential when evaluating focal liver lesions (FLLs) using ultrasonography (US). Microbubble UCAs are easy to use and robust; their use poses no risk of nephrotoxicity and requires no ionizing radiation. The unique features of contrast enhanced US (CEUS) are not only noninvasiveness but also real-time assessing of liver perfusion throughout the vascular phases. The later feature has led to dramatic improvement in the diagnostic accuracy of US for detection and characterization of FLLs as well as the guidance to therapeutic procedures and evaluation of response to treatment. This article describes the current consensus and guidelines for the use of UCAs for the FLLs that are commonly encountered in US. After a brief description of the bases of different CEUS techniques, contrast-enhancement patterns of different types of benign and malignant FLLs and other clinical applications are described and discussed on the basis of our experience and the literature data.

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“…Treatment response after RFA or TACE is most accurately evaluated with Sonazoid ® -enhanced US with a concurrent use of defect reperfusion imaging [35][36][37][38][39].…”

Section: Response Evaluation After Locoregional Therapymentioning

confidence: 99%

Defect Reperfusion Imaging with Sonazoid®: A Breakthrough in Hepatocellular Carcinoma

Kudo¹

2015

Liver Cancer

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Contrast-Enhanced Ultrasound Techniques for Guiding and Assessing Response to Locoregional Treatments for Hepatocellular Carcinoma

Cited by 13 publications

References 107 publications

Management of hepatocellular carcinoma: The role of contrast-enhanced ultrasound

Management of hepatocellular carcinoma: The role of contrast-enhanced ultrasound

Current consensus and guidelines of contrast enhanced ultrasound for the characterization of focal liver lesions

Defect Reperfusion Imaging with Sonazoid®: A Breakthrough in Hepatocellular Carcinoma

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