Contrast-enhanced ultrasound imaging of periadventitial vasa vasorum in human carotid arteries

Magnoni, Marco; Coli, Stefano; Marrocco-Trischitta, Massimiliano M.; Melisurgo, Giulio; Dominicis, D. De; Cianflone, Domenico; Chiesa, Roberto; Feinstein, Steve B.; Maseri, Attilio

doi:10.1093/ejechocard/jen221

Cited by 68 publications

(53 citation statements)

References 30 publications

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“…Third, our population consisted of subjects with a predominance of cardiovascular risk factors and expressed CVD (76% exhibited carotid lesions), therefore our focus was directed at assessing carotid plaque neovascularization not measurements of carotid intima-media thickness. Though, previously, Magnoni et al 12 reported on the direct association between adventitial vasa vasorum and carotid intima-media thickness. This combined approach may be valuable in future prospective studies, which includes screening of subjects considered to be at lower risk.…”

Section: Study Limitationsmentioning

confidence: 93%

Vasa Vasorum and Plaque Neovascularization on Contrast-Enhanced Carotid Ultrasound Imaging Correlates With Cardiovascular Disease and Past Cardiovascular Events

Staub

Patel

Tibrewala

et al. 2010

Stroke

240

145

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Background and Purpose-Histological data associate proliferation of adventitial vasa vasorum and intraplaque neovascularization with vulnerable plaques represented by symptomatic vascular disease. In this observational study, the presence of carotid intraplaque neovascularization and adventitial vasa vasorum were correlated with the presence and occurrence of cardiovascular disease (CVD) and events (CVE). Methods-The contrast-enhanced carotid ultrasound examinations of 147 subjects (mean age 64Ϯ11 years, 61% male)were analyzed for the presence of intraluminal plaque, plaque neovascularization (Grade 1ϭabsent; Grade 2ϭpresent), and degree of adventitial vasa vasorum (Grade 1ϭabsent, Grade 2ϭpresent). These observations were correlated with preexisting cardiovascular risk factors, presence of CVD, and history of CVE (myocardial infarction and transient ischemic attack/stroke). Results-The presence of intraluminal carotid plaque was directly correlated to cardiovascular risk factors, CVD, and CVE (PϽ0.05). Adventitial vasa vasorum Grade 2 was associated with significant more subjects with CVD than vasa vasorum Grade 1 (73 versus 54%, Pϭ0.029). Subjects with intraplaque neovascularization Grade 2 had significantly more often a history of CVE than subjects with intraplaque neovascularization Grade 1 (38 versus 20%, Pϭ0.031).Multivariate logistic regression analysis revealed that presence of plaque was significantly associated with CVD (odds ratio 4.7, 95% CI 1.6 to 13.8) and intraplaque neovascularization grade 2 with CVE (odds ratio 4.0, 95% CI 1.3 to 12.6). Conclusion-The presence and degree of adventitial vasa vasorum and plaque neovascularization were directly associated with CVD and CVE in a retrospective study of 147 patients undergoing contrast-enhanced carotid ultrasound. (Stroke. 2010;41:41-47.)

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Section: Study Limitationsmentioning

confidence: 93%

Vasa Vasorum and Plaque Neovascularization on Contrast-Enhanced Carotid Ultrasound Imaging Correlates With Cardiovascular Disease and Past Cardiovascular Events

Staub

Patel

Tibrewala

et al. 2010

Stroke

240

145

View full text Add to dashboard Cite

show abstract

“…Adventitialderived vasa vasorum neovascularization plays a signifi cant role in atherosclerotic plaque progression and destabilization (2)(3)(4). Investigators in a recent study ( 5 ) have shown that adventitial vasa vasorum density and permeability precede an increase in intima-media thickness, endothelial dysfunction ( 6 ), and, most important, infl ammatory activity of the plaque ( 7,8 ). Plaque instability, which leads to plaque rupture and clinical events, may be triggered by the disruption and leakage of immature neovessels originating from adventitial vasa vasorum ( 9 ).…”

Section: Study Populationmentioning

confidence: 99%

Carotid Artery Atherosclerosis: Effect of Intensive Lipid Therapy on the Vasa Vasorum—Evaluation by Using Dynamic Contrast-enhanced MR Imaging

Dong

Kerwin²,

Chen³

et al. 2011

Radiology

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Purpose:To investigate whether short-term, intensive lipid therapy leads to changes in microvascular characteristics, as measured by using dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging. Materials and Methods:Institutional review board approval and informed consent were obtained for this HIPAA-compatible study. Subjects with established coronary artery disease or carotid artery stenosis of 15% or greater determined by using ultrasonography and with levels of apolipoprotein B of 120 mg/dL (1.2 g/L) or greater were enrolled in an ongoing study (clinical trial NCT00715273). All received intensive lipid therapy to achieve targeted high-and low-density lipoprotein cholesterol levels and underwent serial serum monitoring including high-sensitivity C-reactive protein (HsCRP) level measurements. Carotid artery MR imaging examinations including morphologic and DCE MR images were obtained at baseline and 1 year after treatment. In subjects with advanced lesions ( . 2 mm thick), MR image analysis was performed, including measurement of lipid-rich necrotic core size and kinetic modeling of DCE MR images to assess changes in the transfer constant ( K trans ). The differences in K trans between baseline and 1-year follow-up were compared by using the Wilcoxon signed rank test, and associations were assessed by using the Spearman rank correlation coeffi cient. Results:Twenty-eight subjects with interpretable DCE MR imaging results at both baseline and 1-year follow-up were included. After 1 year of treatment, a signifi cant reduction was found in mean K trans (0.085 min 2 1 6 0.037 [standard deviation] to 0.067 min 2 1 6 0.028, P = .02). Reduction in K trans was not signifi cantly correlated with observed reductions in lipid-rich necrotic core size or reductions in HsCRP level. Conclusion:These fi ndings suggest that DCE MR imaging may be a useful imaging method for the assessment of the therapeutic response of the vasa vasorum in patients with atherosclerotic plaque.Clinical trial registration no. NCT00715273.q RSNA, 2011

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“…This technique was also used for identifying and quantifying carotid artery vasa vasorum and intraplaque neovascularization in patients with atherosclerotic carotid artery lesions (10)(11)(12). A correlation was found between the inflammation observed on histopathologic analysis of the plaque after endarterectomy and the degree of intraplaque neovascularization on CEUS (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Contrast‐Enhanced Ultrasound of the Carotid Artery in Patients With Large Vessel Vasculitis: Correlation With Positron Emission Tomography Findings

Germanò

Macchioni

Possemato

et al. 2016

Arthritis Care & Research

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Objective. To assess the findings of contrast-enhanced ultrasound (CEUS) of carotid arteries in patients with large vessel vasculitis (LVV) and to compare them with those observed using F-FDG uptake (P < 0.001) and maximum standardized uptake value (SUV) in the right carotid artery/mean SUV in the superior vena cava (P 5 0.001). When active vascular 18 F-FDG uptake ( ‡2) was considered the gold standard for defining vascular inflammation, carotid CEUS had a sensitivity of 100% (95% confidence interval [95% CI] 65-100) and a specificity of 92% (95% CI 72-99). The positive likelihood ratio was 12.5 (95% CI 3.3-47.2). Severe vascularization at CEUS and active vascular 18 F-FDG uptake were significantly more frequent in active disease according to Kerr's criteria compared to inactive (P 5 0.001 and P 5 0.002, respectively). Conclusion. Carotid CEUS vascularization grade and the grade of vascular inflammation on 18 F-FDG-PET were correlated in patients with LVV.

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Contrast-enhanced ultrasound imaging of periadventitial vasa vasorum in human carotid arteries

Abstract: Periadventitial contrast signal was detected in all patients and BFI thickness was higher in patient with carotid atherosclerosis and correlated with IMT.

Cited by 68 publications

References 30 publications

Vasa Vasorum and Plaque Neovascularization on Contrast-Enhanced Carotid Ultrasound Imaging Correlates With Cardiovascular Disease and Past Cardiovascular Events

Vasa Vasorum and Plaque Neovascularization on Contrast-Enhanced Carotid Ultrasound Imaging Correlates With Cardiovascular Disease and Past Cardiovascular Events

Carotid Artery Atherosclerosis: Effect of Intensive Lipid Therapy on the Vasa Vasorum—Evaluation by Using Dynamic Contrast-enhanced MR Imaging

Contrast‐Enhanced Ultrasound of the Carotid Artery in Patients With Large Vessel Vasculitis: Correlation With Positron Emission Tomography Findings

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