Contrast-Enhanced Ultrasound for Imaging of Adrenal Masses

Dietrich, CF; Ignee, A.; Barreiros, Ana Paula; Schreiber-Dietrich, Dagmar; Sienz, M.; Bojunga, J; Braden, Barbara

doi:10.1055/s-0028-1109357

Cited by 53 publications

(48 citation statements)

References 16 publications

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“…If adrenal lesions are observed incidentally, the differential diagnosis based on ultrasound appearances should consider malignant adrenal lesions, particularly adrenal cortical carcinomas and pheochromocytomas [3,5–8]. The present study showed the reliability of ultrasound imaging in the characterization of adrenal masses.…”

Section: Discussionmentioning

confidence: 51%

“…The role of adrenal imaging is to differentiate benign ‘leave-alone’ lesions (e.g., adrenocortical adenoma, myelolipoma, and cyst) from suspicious lesions (e.g., pheochromocytoma, metastasis, adrenal cortical carcinoma, and adrenal lymphoma) that warrant further managements [2]. Simple and inexpensive, ultrasound has been widely used in the detection of adrenal masses [3–8]. However, most studies have relied on the follow-up (sometimes short-term follow-up) or results of CT/MRI imaging to confirm the nature of adrenal lesions.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

et al. 2014

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BackgroundThe purpose of this study was to define the ultrasound imaging characteristics of adrenal tumors and to assess the performance of ultrasound in differentiating benign ‘leave-alone’ lesions from suspicious lesions.Material/MethodsWe enrolled 882 patients in this study. The nature of each lesion was determined by histopathology. Ultrasound finding of each lesion was compared with its corresponding histopathologic result. The final study group consisted of 911 adrenal masses in 882 patients. All images were reviewed by 2 experienced investigators in a double blind manner.ResultsThere were 553 adenomas identified in the study, which constituted 60.70% of the lesions. There were 161 pheochromocytomas (17.67%), 49 myelolipomas (5.38%), 39 cysts (4.28%), 37 metastasis (4.06%), 35 ganglioneuromas (3.84%), 22 lymphomas (2.41%), and 15 cortical carcinomas (1.65%). The sensitivity, specificity, and accuracy of ultrasound-based diagnosis were 89%, 99%, and 93.9%, respectively. A positive predictive value of 90.9% and a negative predictive value of 94.2% were obtained in this study.ConclusionsThis large-sample study showed that ultrasound was a reliable method in differentiating benign ‘leave-alone’ lesions from suspicious lesions.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

et al. 2014

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“…The study by Dietrich et al indicated ineptitude to distinguish malignant and benign lesions [6]. On the contrary Friedrich-Rust at al suggested that contrast-enhanced ultrasound may be a useful method in diagnostic work-up of adrenal mass with excellent sensitivity for the diagnosing of malignancy [7].…”

Section: Discussionmentioning

confidence: 97%

“…Recently some new ultrasound modalities have been investigated in regard to adrenal masses differentiation (malignant vs. benign) [6][7][8][9] or within benign group of adrenal masses [10].…”

Section: Introductionmentioning

confidence: 99%

Application of parametric ultrasound contrast agent perfusion studies for differentiation of hyperplastic adrenal nodules from adenomas—Initial study

Słapa

Kasperlik-Załuska²,

Migda

et al. 2015

European Journal of Radiology

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“…CEUS and CE-EUS, both cannot reliably differentiate between benign (endocrine tumors and adenomas) and malignant adrenal masses50 despite some controversial discussion of the subject 51. Adrenal cysts, lipoma and myelolipoma demonstrate a characteristic B-mode US morphology.…”

Section: Adrenal Glandsmentioning

confidence: 99%

Contrast-Enhanced Endoscopic Ultrasound

Dietrich

Sharma

Hocke³

2012

Endosopic Ultrasound

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The European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) introduced guidelines on the use of contrast-enhanced ultrasound (CEUS) in 2004. This EFSUMB-document focused mainly on liver applications. However, new applications extending beyond the liver were developed thereafter. Increased interest in recent years in CEUS technique and in the application of CEUS in novel fields like endoscopic ultrasound (EUS) has revolutionized indications and applications. As a result, the EFSUMB initiated a new update of the guidelines in 2011 to include this additional knowledge. Some of the contrast-enhanced EUS (CE-EUS) indications are established, whereas others are preliminary; these latter indications are categorized as emergent CEUS applications since the available evidence is insufficient for general recommendation. This article focuses on the use of CE-EUS in various clinical settings. The reader will get an overview of current indications and possible applications of CE-EUS. This involves the introduction of different contrast studies including color Doppler techniques (known as contrast-enhanced high mechanical index endosonography or CEHMI-EUS) as well as more modern high-resolution contrast-enhanced techniques (known as contrast-enhanced low mechanical index endosonography or CELMI EUS).

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Contrast-Enhanced Ultrasound for Imaging of Adrenal Masses

Abstract: Contrast-enhanced ultrasound facilitates the visualization of vascularization even in small adrenal masses, but it does not help to distinguish malignant and benign lesions.

Cited by 53 publications

References 16 publications

Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

Application of parametric ultrasound contrast agent perfusion studies for differentiation of hyperplastic adrenal nodules from adenomas—Initial study

Contrast-Enhanced Endoscopic Ultrasound

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