Contrast‐enhanced ultrasound features of focal pancreatic lesions in dogs

Burti, Silvia; Zotti, Alessandro; Rubini, Giuseppe; Orlandi, Riccardo; Bargellini, Paolo; Bonsembiante, Federico; Contiero, Barbara; Banzato, Tommaso

doi:10.1002/vetr.2080

Cited by 4 publications

(7 citation statements)

References 39 publications

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“…In a study by Nagumo et al 2 including 44 dogs diagnosed with CA (six), CAC (12) and PHEO (26), the authors reported PHEO as having a significantly lower mean transit time compared to both CAC and CA. In other words, in their study, PHEO had a fast wash-in followed by a seemingly fast wash-out.…”

Section: Discussionmentioning

confidence: 99%

“…The following qualitative CEUS features were evaluated during the wash-in phase 12,15 : (1) homogeneity of the lesion (homogeneous or non-homogeneous); (2) distribution of the contrast medium (diffused, peripheral or central); (3) hypoperfused areas (present or absent); (4) intralesional microcirculation (present or absent); (5) vascularisation pattern of microcirculation (centripetal, centrifugal, disordered or nodular). During the wash-in phase, vascular invasion was also evaluated.…”

Section: Qualitative and Quantitative Analysismentioning

confidence: 99%

“…The following qualitative features were evaluated during the wash-out phase 12,15 : (1) wash-out (present or absent); (2) redistribution of the contrast medium (present or absent); (3) homogeneity of the lesion (homogeneous or non-homogeneous). Redistribution of the contrast medium was classified as present when the hypoperfused areas disappeared or decreased in size and/or number after the wash-in peak.…”

Section: Qualitative and Quantitative Analysismentioning

confidence: 99%

“…The following quantitative CEUS features of the lesions were evaluated 12,15 : (1) time to enhancement (TTE), which was the timespan between injection and appearance of the signal in the lesion; (2) time to peak (TTP), which was the timespan between injection and the peak intensity of the signal; (3) time to wash-in (TTWI), calculated as TTP minus TTE. When redistribution was evident, the time to redistribution was also calculated as the timespan occurring between injection and the maximum distribution of the contrast medium.…”

Section: Qualitative and Quantitative Analysismentioning

confidence: 99%

“…8 Contrast-enhanced ultrasound (CEUS) has gained some popularity in the last few years. The normal and pathological aspects of several abdominal organs in dogs, such as the liver, spleen, intestine and pancreas, have been published, [9][10][11][12][13] while the CEUS features of normal adrenal glands have been described in six dogs. 14 In five of the six dogs, a peculiar second homogeneous enhancement peak, evident 30-40 seconds after the injection of contrast medium, was described by the authors.…”

Section: Introductionmentioning

confidence: 99%

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Contrast‐enhanced ultrasound features of adrenal lesions in dogs

Burti

Zotti

Rubini³

et al. 2023

Veterinary Record

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Background The contrast‐enhanced ultrasound (CEUS) features of adrenal lesions are poorly reported in veterinary literature. Methods Qualitative and quantitative B‐mode ultrasound and CEUS features of 186 benign (adenoma) and malignant (adenocarcinoma and pheochromocytoma) adrenal lesions were evaluated. Results Adenocarcinomas (n = 72) and pheochromocytomas (n = 32) had mixed echogenicity with B‐mode, and a non‐homogeneous aspect with a diffused or peripheral enhancement pattern, hypoperfused areas, intralesional microcirculation and non‐homogeneous wash‐out with CEUS. Adenomas (n = 82) had mixed echogenicity, isoechogenicity or hypoechogenicity with B‐mode, and a homogeneous or non‐homogeneous aspect with a diffused enhancement pattern, hypoperfused areas, intralesional microcirculation and homogeneous wash‐out with CEUS. With CEUS, a non‐homogeneous aspect and the presence of hypoperfused areas and intralesional microcirculation can be used to distinguish between malignant (adenocarcinoma and pheochromocytoma) and benign (adenoma) adrenal lesions. Limitations Lesions were characterised only by means of cytology. Conclusions CEUS examination is a valuable tool for distinction between benign and malignant adrenal lesions and can potentially differentiate pheochromocytomas from adenocarcinomas and adenomas. However, cytology and histology are necessary to obtain the final diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Qualitative and Quantitative Analysismentioning

confidence: 99%

Section: Qualitative and Quantitative Analysismentioning

confidence: 99%

Section: Qualitative and Quantitative Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contrast‐enhanced ultrasound features of adrenal lesions in dogs

Burti

Zotti

Rubini³

et al. 2023

Veterinary Record

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Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

Ercolin,

Uchoa,

Aires

et al. 2023

Preprint

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The aim of this literature review was to present the novel imaging modalities elastography and contrast-enhanced ultrasonography. We provided an overview of the concepts and applications of each technique for the investigation of neoplastic and metastatic tumors in dogs and cats. Studies with elastography are based on the elasticity and deformation of the evaluated tissue. The information obtained from the different types of elastography can aid in the detection and differentiation of malignant and benign structures. Descriptions of elastographic studies in several organs and tissue in veterinary medicine reported that, in general, malignant tumors tend to be more rigid, and, therefore, less deformable than benign lesions or in comparison to the healthy parenchyma. Contrast-enhanced ultrasonography is based on the intravenous injection of contrast media constituted by microbubbles. This imaging modality can be performed in non-sedated animals and provides information on the tissue perfusion, allowing the investigation of macro- and micro-circulation. Studies with different organs and tissues were performed in dogs and cats and revealed a tendency of malignant tumors to present faster transit of the contrast media (time to wash-in, peak and wash-out). These advanced techniques can be associated with other imaging modalities, aiding important information to the well-established exams of B-mode and Doppler ultrasonography. They can be used as screening tests, potentially representing an alternative to the invasive sampling methods required for cytological and histopathological analysis.

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Laparoscopic partial pancreatectomy through an advanced lateral approach as treatment for insulinoma in dogs: a case series

Keulen,

van Nimwegen

2024

Front. Vet. Sci.

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A minimally invasive partial pancreatectomy was performed through a novel laparoscopic lateral flank approach in sternal-oblique recumbency in four clinical cases presented with an insulinoma. All four cases were female castrated dogs of older age (range 7–9 years) and different breeds (Wire haired dachshund, German shepherd, Jack Russel terrier, and Boxer), and all presented with episodic weakness, tremors, and/or seizures. The diagnosis was based on plasma glucose level below reference range with concomitant increased or normal insulin level. A laparoscopic approach was considered based on triple-phase contrast-enhanced computed tomography findings of the abdomen, revealing a pancreatic mass situated in the right pancreatic limb or left pancreatic limb without suspicion of metastasis. Laparoscopic procedures were performed without any major complications, and peri-operative glycemia increased to (supra-)normal levels in all cases. Histopathologic reports qualified the masses as neuroendocrine carcinomas, and in conjunction with the clinical picture, this neoplasia was further defined as insulinoma. Post-operative care in an intensive care unit was of short duration, and all animals were discharged being clinically normal and normoglycemic in between 1.5 and 2.5-day post-surgery. At short-term follow-up, no dogs showed clinical abnormalities, all recovered well from the surgical procedure, and blood glucose levels remained in the normal range. During long-term follow-up, 2 cases remained clinically normal at the time of writing, 564 and 1,211 days after surgery, 1 dog had recurrence of hypoglycemic episodes after 246 days and was euthanized after 673 days of surgery due to progressing disease, and 1 dog was euthanized after 1,028 days of surgery due to reasons unrelated to the insulinoma. Survival times ranged from 599 to 1,232 days after diagnosis. Considering the highly metastatic nature and difficulty of full laparoscopic staging of insulinoma patients, thorough pre-operative disease staging is warranted when considering a laparoscopic approach. This case series shows the feasibility of a novel laparoscopic flank approach for right and left partial pancreatectomy in dogs. Furthermore, proper case selection resulted in favorable outcome in these insulinoma patients.

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Contrast‐enhanced ultrasound features of focal pancreatic lesions in dogs

Cited by 4 publications

References 39 publications

Contrast‐enhanced ultrasound features of adrenal lesions in dogs

Contrast‐enhanced ultrasound features of adrenal lesions in dogs

Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

Laparoscopic partial pancreatectomy through an advanced lateral approach as treatment for insulinoma in dogs: a case series

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