Contrast enhanced ultrasonography (CEUS) in the characterization of tumor microcirculation. Validation of the procedure in the animal experimental model

Badea, Alexandru; Tamas-Szora, Attila; Clichici, Simona; Socaciu, Mihai; Tăbăran, Alexandra; Băciuț, Grigore; Cătoi, C.; Muresan, Adriana; Buruian, Mircea; Badea, Radu

doi:10.11152/mu.2013.2066.152.afb1ats2

Cited by 17 publications

(18 citation statements)

References 33 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relevant analysis software has been developed to analyze ultrasound signal intensity (SI) patterns obtained by imaging continuously prior or subsequent to treatment, and information regarding tissue blood flow and vascular integrity, branching patterns and density will be assessed (8). As reported previously, the information extracted from the CEUS data was similar to that obtained from DCE-MRI (9), and CEUS has numerous benefits, including a sufficient high safety profile that is acceptable for patients with renal failure or an iodine allergy, absence of radiation, easy reproducibility and high temporal resolution (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 81%

Parametric contrast-enhanced ultrasound as an early predictor of radiation-based therapeutic response for lymph node metastases of nasopharyngeal carcinoma

Huang

Zhou

et al. 2014

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Nasopharyngeal carcinoma (NPC) is a common type of cancer in South East Asia with peculiar epidemiology, pathology, clinical behavior and response to treatment characteristics. To the best of our knowledge, this is the first study to investigate the use of a contrast-enhanced ultrasound (CEUS) as a predictor for the therapeutic response in lymph node metastases of NPC patients treated with radiation-based therapy. Sixty-seven NPC patients with lymph node metastases underwent the lymph nodes CEUS examination twice; pre-and in-treatment (at the 5th fraction radiotherapy), respectively. The CEUS parameters were acquired through Qontrast_4.0 software and mainly included peak intensity (PI) and time to peak (TTP). The response assessment at the lymph nodes revealed a complete response (CR) in 48 patients and partial response (PR) in 19 patients. There was a significant difference in pre-treatment PI (PI pre ) between the patients who showed CR or PR, but the predicted sensitivity and specificity of PI pre was low. The mean in-treatment PI (PI in ) value of the lymph nodes that achieved a CR was 34.24±3.78%, which was significantly higher than the PI in value for PR, 25.62±2.30% (P<0.001). Furthermore, the PI ratio , a PI-quotient, was calculated by dividing the PI in by the corresponding PI pre . The higher PI ratio was also observed in CR lymph nodes (0.81±0.01 vs. 0.66±0.01; P=0.001), and the mean change in PI (PI Δ ; PI Δ = PI pre -PI in ) was smaller in the patients with CR nodes compared to the patients with PR nodes (7.79±3.28 vs. 13.77±1.90%; P=0.000). No difference was observed in TTP pre or TTP in between the CR or PR lymph nodes patients. A receiver operating characteristic curve was constructed to assess the accuracy of the parameters for the prediction of the therapeutic responses. The sensitivity and specificity of PI in in predicting the therapeutic response was 94.3 and 88.2%, and the corresponding figures of the PI ratio were 92.5 and 83.8%, respectively. The CEUS parameters during the early course of radiation-based therapy, PI in and PI ratio , are associated with the therapeutic response of NPC lymph node metastases, with a high predicted sensitivity and specificity, thus yielding the conceivable predictors with the potential to individualize treatment.

show abstract

Section: Introductionmentioning

confidence: 81%

Parametric contrast-enhanced ultrasound as an early predictor of radiation-based therapeutic response for lymph node metastases of nasopharyngeal carcinoma

Huang

Zhou

et al. 2014

Molecular and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…Similarly, the Doppler shifts in ultrasonic waves are used to assess flow velocities. Usually used to measure blood flow in conduit vessels, combinations of blood contrast agents and high-resolution ultrasound make it possible to generate an index of microvascular perfusion [112]. The advantage with ultrasound is that it is possible to capture tissue anatomical information simultaneous with flow data.…”

Section: Perfusionmentioning

confidence: 99%

“…Common approaches to directly assess perfusion in the experimental and clinical settings generally include some aspect of imaging such as Doppler-based imaging (optical or sonic), fluorescence-based imaging, or direct visualization via microscopy [111][112][113][114]. Laser Doppler perfusion imaging (LDPI) is commonly used to generate an index of perfusion or blood flux (the product of the velocity and number of moving erythrocytes (RBCs)) in microvascular beds.…”

Section: Perfusionmentioning

confidence: 99%

Biofabrication of Vascular Networks

Hoying

Williams

2015

Essentials of 3D Biofabrication and Translation

View full text Add to dashboard Cite

“…The gray scale investigation may detect tumors if they show a significant thickening of the intestine wall (with or without lumen stenosis) or if they present as a large intraluminal mass (polypoid tumors). I.v administration of CA increases the trustworthiness of the diagnosis by visualizing the arborescent vascular signal characteristic to neoformation [28]. The CEUS behavior of intestinal tumors is uncharacteristic [29].…”

Section: Small Intestinementioning

confidence: 99%

Oral and IV Contrast Enhanced Ultrasonography of the digestive tract â€“ a useful completion of the B-mode examination: a literature review and an exhaustive illustration through images

et al. 2015

Self Cite

View full text Add to dashboard Cite

Contrast enhanced ultrasonography, using IV and/or oral/rectal contrast agents, represents a technical development of the US method, which has proved its applicability in the qualitative and quantitative assessment of the normal and pathological circulatory bed, as well as of the digestive lumen. The use of microbubbles and harmonics opens a new horizon in the detection and characterization of the inflammatory and tumoral conditions of the digestive tract. The interpretation of the data requires corroboration with the grey scale aspect of the examined lesion/area, as well as with the clinical context of the case and the results of other diagnosis techniques. The purpose of this paper is to review the main applications of CEUS in digestive tract pathology by analyzing the significant literature and guidelines in the light of our personal experience and demonstrating it through suggestive images.

show abstract

Contrast enhanced ultrasonography (CEUS) in the characterization of tumor microcirculation. Validation of the procedure in the animal experimental model

Cited by 17 publications

References 33 publications

Parametric contrast-enhanced ultrasound as an early predictor of radiation-based therapeutic response for lymph node metastases of nasopharyngeal carcinoma

Parametric contrast-enhanced ultrasound as an early predictor of radiation-based therapeutic response for lymph node metastases of nasopharyngeal carcinoma

Biofabrication of Vascular Networks

Oral and IV Contrast Enhanced Ultrasonography of the digestive tract â€“ a useful completion of the B-mode examination: a literature review and an exhaustive illustration through images

Contact Info

Product

Resources

About