Contrast-enhanced multiphasic CT and MRI findings of adenosquamous carcinoma of the pancreas

Ding, Yuqin; Zhou, Jianjun; Sun, Huihong; He, Da; Zeng, Mengsu; Rao, Sheng-Xiang

doi:10.1016/j.clinimag.2013.08.002

Cited by 28 publications

(18 citation statements)

References 30 publications

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“…Imaging modalities such as Computed Tomography (CT) and Magnetic Resonance (MR) are routinely performed during the follow-up of oncologic patients [6][7][8][9][10]. In this setting CT and MR may play a crucial role in the early identification of PM, but their part in the management of PM has been evaluated only on small series of patients [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

et al. 2018

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“…However, a study published examining whole genomic menon may reflect the presence of the squamous component causing rapid proliferation, as these characteristics are not seen as often in adenocarcinoma of the pancreas [43] . Other unique features noted in imaging evaluation with ASCP are the lack of pancreatic atrophy and mild duct dilatation, which are more common features of pancreatic adenocarcinoma [42] . Like adenocarcinoma of the pancreas, adenosquamous cancers of the pancreas may exhibit the double duct sign [38] , which consists of simultaneous dilatation of the common bile and pancreatic ducts [44] .…”

Section: Imagingmentioning

confidence: 99%

“…Another common imaging finding is the propensity for vascular and nerve encasement [38] . A large series looking at ASCP through CT and magnetic resonance imaging showed the presence of frequent intra-tumor necrosis, increased enhancement, and exophytic growth [42] . It is theorized that this phenoother squamous histology cancers such as the cervix, head and neck, and anus [13] .…”

Section: Imagingmentioning

confidence: 99%

Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review

Borazanci

Millis

Korn

et al. 2015

WJGO

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Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma of the pancreas, overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP. Molecular characterization revealed overexpression in MRP1 (80%), MGMT (79%), TOP2A (75), RRM1 (42%), TOPO1 (42%), PTEN (45%), CMET (40%), and C-KIT (10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered

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“…One study[ 13 ] used an IHC commercial assay[ 14 ] of molecular markers which are implicated in anti-tumor drug performance, showing TOPO2A, MRP1, BCRP and MGMT overexpression. There is not a definitive sign of ASPC in imaging tests, but some studies remark that it is frequently round or has a lobulated shape[ 15 ] with ill-defined borders[ 16 ], and characteristically demonstrates central necrotic areas[ 15 ]. It usually displays peripheral contrast enhancement in the arterial phase, which persists in the venous phase[ 17 ], and thrombus in the portal vein system is often present[ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in aCDKN2Agermline mutation carrier

Juan

Escribano

Lapiedra

et al. 2017

WJGO

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A 69-year-old woman from a kindred with familial atypical multiple mole melanoma and carrier of a germline mutation in CDKN2A, presented with abdominal pain caused by a solid-cystic pancreatic mass. The patient had an abdominal computed tomography three years before in which there was no evidence of pancreatic lesion. The endoscopic ultrasound guided fine needle aspiration showed adenocarcinoma with squamous component. After surgical resection the final diagnosis was adenosquamous pancreatic carcinoma (ASPC) arising in an intraductal papillar mucinous neoplasm (IPMN). Adenosquamous carcinomas are uncommon in the pancreas and have rarely been described in association with IPMNs. It has worse prognosis than the ordinary pancreatic ductal adenocarcinoma and some distinct features. We review the clinical, imaging, pathologic and molecular aspects of ASPC. Differential diagnosis with contamination, squamous metaplasia and pancreatic metastases from a distant squamous carcinoma is discussed. Besides, the case is an accelerated model of the adenoma (IPMN)-carcinoma sequence probably due to the CDKN2A germline mutation. Somatic CDKN2A mutations are common events in the early steps of sporadic pancreatic cancer, but germline mutation carriers have a significantly higher risk of pancreatic carcinoma.

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Contrast-enhanced multiphasic CT and MRI findings of adenosquamous carcinoma of the pancreas

Cited by 28 publications

References 30 publications

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review

Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in aCDKN2Agermline mutation carrier

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