Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study

Wagner, Anja; Mahrholdt, Heiko; Holly, Thomas A.; Elliott, Michael D.; Regenfus, Matthias; Parker, Michele; Klocke, Francis J.; Bonow, Robert O.; Kim, Raymond J.; Judd, Robert M.

doi:10.1016/s0140-6736(03)12389-6

Cited by 1,160 publications

(698 citation statements)

References 22 publications

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“…DELAYED CONTRAST-ENHANCED VIABILITY magnetic resonance imaging (MRI) of the myocardium is a valuable tool for the detection of myocardial infarction (MI), various types of cardiomyopathies, and postinterventional findings (1)(2)(3)(4)(5)(6)(7)(8). Because of its high spatial resolution and image contrast, viability MRI visualizes the subendocardial MI and myocardial damage associated with hypertrophic cardiomyopathy (HCM) and sarcoidosis that cannot be detected with other imaging modalities (5)(6)(7).…”

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confidence: 99%

“…Because of its high spatial resolution and image contrast, viability MRI visualizes the subendocardial MI and myocardial damage associated with hypertrophic cardiomyopathy (HCM) and sarcoidosis that cannot be detected with other imaging modalities (5)(6)(7). The transmural extension of MI and myocardial fibrosis in HCM assessed using delayed contrast-enhanced viability imaging are strongly related to regional and global cardiac function, remodeling, and indications for revascularization (1,4,6).…”

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confidence: 99%

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Free‐breathing high‐spatial‐resolution delayed contrast‐enhanced three‐dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

Amano

Matsumura

Kumita

2008

Magnetic Resonance Imaging

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Purpose:To assess the feasibility of free-breathing highspatial-resolution delayed contrast-enhanced three-dimensional (3D) viability magnetic resonance imaging (MRI) at 3.0T for the detection of myocardial damages. Materials and Methods:Twenty-five patients with myocardial diseases, including myocardial infarction and cardiomyopathies, were enrolled after informed consent was given. Free-breathing 3D viability MRI with high spatial resolution (1.5 ϫ 1.25 ϫ 2.5 mm) at 3.0T, for which cardiac and navigator gating techniques were employed, was compared with breath-hold two-dimensional (2D) viability imaging (1.77 ϫ 1.18 ϫ 10 mm) for assessment of contrastto-noise ratio (CNR) and myocardial damage.Results: Free-breathing 3D viability imaging was achieved successfully in 21 of the 25 patients. This imaging technique depicted 84.6% of hyperenhancing myocardium with a higher CNR between hyperenhancing myocardium and blood and with excellent agreement for the transmural extension of myocardial damage (k ϭ 0.91). In particular, the 3D viability images delineated the myocardial infarction and linear hyperenhancing myocardium, comparable to the 2D viability images. Conclusion:Free-breathing high-spatial-resolution delayed contrast-enhanced 3D viability MRI using 3.0T was feasible for the evaluation of hyperenhancing myocardium, as seen with myocardial infarction and cardiomyopathies.

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confidence: 99%

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confidence: 99%

Free‐breathing high‐spatial‐resolution delayed contrast‐enhanced three‐dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

Amano

Matsumura

Kumita

2008

Magnetic Resonance Imaging

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“…This is because it has been conclusively shown that delayed hyper-enhancement seen on MRI (DE-MRI) is exclusively associated with myocyte necrosis. 8,9 The utility of CMRI in apical ballooning was recently investigated by Mitchell et al 10 Though, there were concerns about resolution of CMRI to detect changes at microscopic level, excellent correlation has been shown between DE-MRI and histopathology even for small infarcts. 8,9,11,12 It is important to note that regions subjected to severe but reversible ischaemic injuries do not hyper-enhance on DE-MRI, even in the presence of myocardial stunning.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging findings in apical ballooning syndrome or takotsubo cardiomyopathy

Jambhekar

Pandey

Kaushik

et al. 2012

Indian Heart Journal

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A B S T R A C TCardiac magnetic resonance imaging (CMRI) plays an important role in the diagnosis and followup of apical ballooning syndrome (takotsubo syndrome), a recently described cardiac condition characterised by transient dyskinesia of the left ventricle secondary to an acute emotional event.We present the CMRI findings in a 53-year-old female diagnosed with apical ballooning syndrome and discuss its value in the diagnosis and follow-up of this condition.

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“…Late gadolinium enhancement CMR detects myocardial infarction accurately, with superior histological correlation compared to nuclear techniques [19]. This has become an active area of research in the CRT setting, with several subsequent studies documenting the value of scar burden, location and transmurality of myocardial infarctions as a predictor of response to CRT [20-24].…”

Section: Discussionmentioning

confidence: 99%

Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy

Alpendurada

Guha

Sharma

et al. 2011

Journal of Cardiovascular Magnetic Resonance

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BackgroundCardiac resynchronization therapy (CRT) is an established treatment in advanced heart failure (HF). However, an important subset does not derive a significant benefit. Despite an established predictive role in HF, the significance of right ventricular (RV) dysfunction in predicting clinical benefit from CRT remains unclear. We investigated the role of RV function, assessed by cardiovascular magnetic resonance (CMR), in predicting response to and major adverse clinical events in HF patients undergoing CRT.MethodsSixty consecutive patients were evaluated with CMR prior to CRT implantation in a tertiary cardiac centre. The primary end-point was a composite of death from any cause or unplanned hospitalization for a major cardiovascular event. The secondary end-point was response to therapy, defined as improvement in left ventricular ejection fraction ≥ 5% on echocardiography at one year.ResultsEighteen patients (30%) met the primary end-point over a median follow-up period of 26 months, and 27 out of 56 patients (48%) were considered responders to CRT. On time-to-event analysis, only atrial fibrillation (HR 2.6, 95% CI 1.02-6.84, p = 0.047) and RV dysfunction, either by a reduced right ventricular ejection fraction-RVEF (HR 0.96, 95% CI 0.94-0.99, p = 0.006) or tricuspid annular plane systolic excursion-TAPSE (HR 0.88, 95% CI, 0.80-0.96, p = 0.006), were significant predictors of adverse events. On logistic regression analysis, preserved RVEF (OR 1.05, 95% CI 1.01-1.09, p = 0.01) and myocardial scar burden (OR 0.90, 95% CI 0.83-0.96, p = 0.004) were the sole independent predictors of response to CRT. Patients with marked RV dysfunction (RVEF < 30%) had a particularly low response rate (18.2%) to CRT.ConclusionsRight ventricular function is an important predictor of both response to CRT and long-term clinical outcome. Routine assessment of the right ventricle should be considered in the evaluation of patients for CRT.

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Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study

Cited by 1,160 publications

References 22 publications

Free‐breathing high‐spatial‐resolution delayed contrast‐enhanced three‐dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

Free‐breathing high‐spatial‐resolution delayed contrast‐enhanced three‐dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

Magnetic resonance imaging findings in apical ballooning syndrome or takotsubo cardiomyopathy

Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy

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