Contrast enhanced MRI and Diffusion Weighted Imaging (DWI) in the evaluation of renal cell carcinoma and differentiation of its subtypes

Hassanen, Omar; Ghieda, Usama Elsaied; Eltomey, Mohamed Adel

doi:10.1016/j.ejrnm.2017.03.024

Cited by 2 publications

(2 citation statements)

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“…The mean ADC value for ccRCC (1.56 ± 0.27 × 10 −3 mm 2 /s) was significantly higher than that of pRCC (0.96 ± 0.25 × 10 −3 mm 2 /s, P < 0.001) and cbRCC (0.89 ± 0.29 × 10 −3 mm 2 /s, P < 0.001). Similar to our results, Hassanen et al reported that the mean ADC value of clear cell RCC (1.789 ± 0.5624 × 10 −3 mm 2 /s) was significantly higher (P = 0.0003) than that of both papillary RCC (1.034 ± 0.3411 × 10 −3 mm 2 /s) and chromophobe RCC (1.19 × 10 −3 mm 2 /s) [18]. We found that the cutoff value of ADC in differentiation between clear cell RCC and non-clear cell RCC Fig.…”

Section: Discussionsupporting

confidence: 91%

“…Axial nonenhanced (b) and gadolinium-enhanced T1-W spoiled GRE-MR images in corticomedullary (c) and nephrographic (d) show early and moderate heterogeneous enhancement of the mass in corticomedullary and nephrographic phases. Axial DWI (b800mm 2 /s) (e) and ADC maps (f) show restriction of diffusion into the renal mass with ADC value (1.1 × 10 − 3 mm 2 /s) [18].…”

Section: Discussionmentioning

confidence: 99%

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Quantitative 3-tesla multiparametric MRI in differentiation between renal cell carcinoma subtypes

Elsorougy

Farg

Bayoumi

et al. 2021

Egypt J Radiol Nucl Med

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Background MRI provides several distinct quantitative parameters that may better differentiate renal cell carcinoma (RCC) subtypes. The purpose of the study is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC), chemical shift signal intensity index (SII), and contrast enhancement in differentiation between different subtypes of renal cell carcinoma. Results There were 63 RCC as regard surgical histopathological analysis: 43 clear cell (ccRCC), 12 papillary (pRCC), and 8 chromophobe (cbRCC). The mean ADC ratio for ccRCC (0.75 ± 0.13) was significantly higher than that of pRCC (0.46 ± 0.12, P < 0.001) and cbRCC (0.41 ± 0.15, P < 0.001). The mean ADC value for ccRCC (1.56 ± 0.27 × 10−3 mm2/s) was significantly higher than that of pRCC (0.96 ± 0.25 × 10−3 mm2/s, P < 0.001) and cbRCC (0.89 ± 0.29 × 10−3 mm2/s, P < 0.001). The mean SII of pRCC (1.49 ± 0.04) was significantly higher than that of ccRCC (0.93 ± 0.01, P < 0.001) and cbRCC (1.01 ± 0.16, P < 0.001). The ccRCC absolute corticomedullary enhancement (196.7 ± 81.6) was significantly greater than that of cbRCC (177.8 ± 77.7, P < 0.001) and pRCC (164.3 ± 84.6, P < 0.001). Conclusion Our study demonstrated that multiparametric MRI is able to afford some quantitative features such as ADC ratio, SII, and absolute corticomedullary enhancement which can be used to accurately distinguish different subtypes of renal cell carcinoma.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%