Quantitative 3-tesla multiparametric MRI in differentiation between renal cell carcinoma subtypes

The term multiparametric MRI, is a useful tool in reference to an approach that takes advantage of the added value of different MR imaging acquisitions to yield anatomic and pathophysiologic information about renal space occupying lesions and to evaluate patients with different tumors, including genitourinary malignancies. The role of multiparametric MRI is continuously growing because of its ability to detect and characterize renal space occupying lesions as well as to assess response to treatment. An observational study was carried out in 50 patients who presented with renal mass, based on clinical suspicion and prior imaging diagnosis of neoplastic renal space occupying lesion. Total renal space occupying lesions were 50, of which, 38 were males & 12 were females. The age range of the study population was 30–80 years. In our study, Agreement analysis between mpMRI diagnosis and HPE diagnosis of different RCC subtypes was statistically significant. So, multiparametric MRI had a role in differentiating the subtypes of RCC which had fair agreement with HPE. The present study results state that the renal mass lesions has different ADC values for different lesions because of the change in tissue contents and there was a statistically significant difference in ADC values between low and high-stage RCCs. Histologic and radiologic profiles of renal space occupying lesions and diverse subtypes of RCC can be used as biologic indicators of clinical behavior, response to treatment, and prognosis.

show abstract

“…3 Quantitative features like absolute corticomedullary enhancement, ADC ratio is possible with the use of 3 Tesla mpMRI. 4…”

Section: Introductionmentioning

confidence: 99%

Evaluation of renal space occupying lesions with multiparametric MRI and its correlation with histopathology findings- an observational study

et al. 2022

View full text Add to dashboard Cite

show abstract

Multiparametric MRI for characterization of the tumour microenvironment

Hoffmann,

Masthoff,

Kunz

et al. 2024

Nat Rev Clin Oncol

View full text Add to dashboard Cite

DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation

Shaaban

Ayad

Sharafeldeen

et al. 2021

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background Renal masses are becoming an increasingly common finding on cross-sectional images. Characterization of the nature of the lesion either neoplastic or not, benign or malignant as well as further subtype characterization is becoming an important factor in determining management plan. The purpose of our study with to assess the sensitivity and specificity of both ADC mean value and ADC ratio in such characterization along with the calculation of different cutoff values to differentiate between different varieties, using pathological data as the main gold standard for diagnosis. Results Our study included 50 patients with a total of 72 masses. A final diagnosis was reached in 69 masses by pathological examination and three masses had clinical and laboratory signs of infection. We had a total of 49 malignant lesions (68%) and 23 benign lesions (32%). The ADC value of ccRCC (1.4 × 10−3 mm2/s) was significantly higher than all other renal masses. A cutoff ADC value of > 1.1 and a cutoff ADC ratio of > 0.56 can be used to differentiate between clear cell renal cell carcinoma and other lesions and an ADC value of < 0.8 and an ADC ratio of ≤ 0.56 to differentiate papillary renal cell carcinoma from other masses. There was no statistically significant ADC value to differentiate between benign and malignant lesions but a statistically significant ADC ratio (> 0.52) was reached. Conclusion ADC value and ADC ratio can be used as an adjunct tool in the characterization of different renal masses, with ADC ratio having a higher sensitivity, which can affect the prognosis and management of the patient.

show abstract

Quantitative 3-tesla multiparametric MRI in differentiation between renal cell carcinoma subtypes

Cited by 4 publications

References 22 publications

Evaluation of renal space occupying lesions with multiparametric MRI and its correlation with histopathology findings- an observational study

Evaluation of renal space occupying lesions with multiparametric MRI and its correlation with histopathology findings- an observational study

Multiparametric MRI for characterization of the tumour microenvironment

DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation

Contact Info

Product

Resources

About