Contrast-enhanced MR imaging of the breast: comparison of two different doses of gadopentetate dimeglumine.

Heywang-Köbrunner, S. H.; Haustein, Jens; Pohl, Christoph; Beck, Rainer; Lommatzsch, B.; Untch, Michael; Nathrath, W

doi:10.1148/radiology.191.3.8184040

Cited by 77 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While the accepted dose ranges between 0.1 and 0.2 mmol per kilogram of body weight, the majority of groups use a dose of 0.1 mmol/kg. There is only one study of which this author is aware that prospectively investigated the effect of a higher dose (0.2 mmol/kg) and concluded that the higher dose improves sensitivity (30). However, this study stems from a time when neither fat saturation nor subtraction was available, such that cancers had to appear brighter than fatty tissue to be detected reliably, which certainly is an expensive way to highlight enhancing lesions.…”

Section: Contrast Material: How Much How Applied?mentioning

confidence: 99%

The Current Status of Breast MR Imaging Part I. Choice of Technique, Image Interpretation, Diagnostic Accuracy, and Transfer to Clinical Practice

2007

View full text Add to dashboard Cite

Compared with mammography and breast ultrasonography, contrast material-enhanced magnetic resonance (MR) imaging is a breast imaging technique that offers not only information on lesion cross-sectional morphology but also on functional lesion features such as tissue perfusion and enhancement kinetics. After an enthusiastic start to clinical breast MR imaging in the early 1990s, a variety of difficulties and obstacles were identified that hampered the transfer of the modality into clinical practice, including a lack of standardization regarding image acquisition and interpretation guidelines, a lack of MR-compatible interventional materials, and a lack of evidence regarding its diagnostic accuracy--particularly specificity and positive predictive value, as well as sensitivity for ductal carcinoma in situ. This article is the first of two on the current status of breast MR imaging. The pathophysiologic basis of breast MR and the effects on acquisition technique and diagnostic accuracy, the diverging demands of high spatial and temporal resolution, and the different approaches that exist for image acquisition are reviewed. Advantages and disadvantages of different pulse sequence parameters are discussed to help radiologists make a balanced and informed decision regarding choice of image acquisition protocol. Imaging findings in common benign and malignant changes are described, and current concepts for differential diagnosis, including the MR Breast Imaging Reporting and Data System lexicon, are discussed. Furthermore, obstacles that impeded the technique's transfer into clinical practice are discussed, and the progress made in recent years, especially regarding the development of guidelines, procedural standardization, and MR-guided interventions are outlined.

show abstract

Section: Contrast Material: How Much How Applied?mentioning

confidence: 99%

The Current Status of Breast MR Imaging Part I. Choice of Technique, Image Interpretation, Diagnostic Accuracy, and Transfer to Clinical Practice

2007

View full text Add to dashboard Cite

show abstract

“…Most investigators report the use of a contrast agent dose of 0.1 mmol per kilogram of body weight. While the results of one study (16) suggested that the conspicuity of malignant lesions was improved at a gadolinium dose of 0.16 mmol/kg as compared with a dose of 0.1 mmol/kg, there are as yet no large-scale well-controlled studies in which a higher dose of contrast agent has been shown to lead to greater diagnostic accuracy.…”

Section: Use Of Paramagnetic Contrast Agentsmentioning

confidence: 99%

MR Imaging of the Breast for the Detection, Diagnosis, and Staging of Breast Cancer

Orel

Schnall²

2001

Radiology

683

422

View full text Add to dashboard Cite

With the introduction of contrast agents, advances in surface coil technology, and development of new imaging protocols, contrast agent-enhanced magnetic resonance (MR) imaging has emerged as a promising modality for detection, diagnosis, and staging of breast cancer. The reported sensitivity of MR imaging for the visualization of invasive cancer has approached 100%. There are many examples in the literature of MR imaging--demonstrated mammographically, sonographically, and clinically occult breast cancer. Often, breast cancer detected on MR images has resulted in a change in patient care. Despite these results, there are many unresolved issues, including no defined standard technique for contrast-enhanced breast MR imaging, no standard interpretation criteria for evaluating such studies, no consensus on what constitutes clinically important enhancement, and no clearly defined clinical indications for the use of MR imaging. Furthermore, this technology remains costly, and issues of cost-effectiveness and cost competition from percutaneous biopsy have yet to be fully addressed. These factors along with the lack of commercially available MR imaging--guided localization and biopsy systems have slowed the transfer of this imaging technology from research centers to clinical breast imaging practices. Technical requirements, potential clinical applications, and potential pitfalls and limitations of contrast-enhanced MR imaging as a method to help detect, diagnose, and stage breast cancer will be described.

show abstract

“…7 In recent years, dynamic contrast enhanced MRI techniques have also been developed for differentiation of benign from malignant tumors, and their limitations discussed. 7,8,14 One limitation, at any rate, is that the soft-tissue details are often compromised due to the dense breast parenchyma. The tumor size as measured by MRI correlates best with pathological tumor size.…”

Section: Introductionmentioning

confidence: 99%

Volume localizedin vivo proton MR spectroscopy of breast carcinoma: variation of water–fat ratio in patients receiving chemotherapy

et al. 1998

View full text Add to dashboard Cite

Contrast-enhanced MR imaging of the breast: comparison of two different doses of gadopentetate dimeglumine.

Abstract: The higher dose of contrast material allowed much better results. Dose comparison studies are also recommended for other techniques.

Cited by 77 publications

References 0 publications

The Current Status of Breast MR Imaging Part I. Choice of Technique, Image Interpretation, Diagnostic Accuracy, and Transfer to Clinical Practice

The Current Status of Breast MR Imaging Part I. Choice of Technique, Image Interpretation, Diagnostic Accuracy, and Transfer to Clinical Practice

MR Imaging of the Breast for the Detection, Diagnosis, and Staging of Breast Cancer

Volume localizedin vivo proton MR spectroscopy of breast carcinoma: variation of water–fat ratio in patients receiving chemotherapy

Contact Info

Product

Resources

About