NMR Biomed.
 1998
DOI: 10.1002/(sici)1099-1492(199812)11:8<414::aid-nbm537>3.0.co;2-w
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Volume localizedin vivo proton MR spectroscopy of breast carcinoma: variation of water–fat ratio in patients receiving chemotherapy

N. R. Jagannathan
1
,
Meenakshi Singh
2
,
Varan Govind
3
et al.
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Cited by 101 publications

(153 citation statements)
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“…Furthermore, no decrease in W/F-ratio was observed from baseline to after one cycle of chemotherapy. Our results are thus contradictory to previous findings, as Jagannathan et al [37] described significantly decreased W/F ratio after 1-2 cycles of chemotherapy compared to baseline values. In more recent studies, a prognostic potential of the W/F ratio has been reported both by Kumar et al [36] and Manton et al [38].…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Furthermore, no decrease in W/F-ratio was observed from baseline to after one cycle of chemotherapy. Our results are thus contradictory to previous findings, as Jagannathan et al [37] described significantly decreased W/F ratio after 1-2 cycles of chemotherapy compared to baseline values. In more recent studies, a prognostic potential of the W/F ratio has been reported both by Kumar et al [36] and Manton et al [38].…”
Section: Discussioncontrasting
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The water to fat ratios of seven patients are also presented in Figure 5 (left). Compared to the ratios of healthy subjects, both ratios were significantly elevated in breast cancer patients, in complete agreement with the previously reported results using the conventional 1D spectroscopy (4, 5).…”
Section: Resultssupporting
confidence: 92%
“…Cho has three N‐methyl protons, giving rise to a stronger diagonal peak at (F 2 = F 1 = 3.25 ppm) and an asymmetric 2D cross peak at (F 2 = 4ppm and F 1 = 3.5 ppm). The presence of Cho in this patient was in conformity with the previously reported 1D spectra of ductal carcinomas (5–7). There were also 2D diagonal peaks at 7.8, 8.0, and 8.2 ppm on the low field end of the spectrum, probably due to the exchangeable protons of cytosolic proteins and the aromatic protons of adenosine nucleotides.…”
Section: Resultssupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The ROC curve analyses of the data suggest that with W/F ratio alone, IDC tumors can be differentiated from benign lesions/normal tissue with high sensitivity and specificity. Consistent with other reports (15, 26, 27, 34, 35), our data show that water resonance dominates the spectra of tumor tissues compared with normal tissue or benign breast lesions. This may be due to elevated amounts of water from increased vasculature or apoptosis.…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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