Contrast-Enhanced Magnetic Resonance Angiography of Cerebral Arteries

Parker, Dennis L.; Tsuruda, Jay S.; Goodrich, K. Craig; Alexander, Andrew L.; Buswell, Henry R.

doi:10.1097/00004424-199809000-00012

Cited by 65 publications

(31 citation statements)

References 38 publications

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“…[6,7] Four Gd III complexes have been approved for clinical use, and are widely used, for example, for the detection of abnormalities of the blood ± brain barrier. [15,199] Complexes containing DTPA (see 1, Magnevist) and DOTA ligands (see 2, Dotarem) are ionic, whereas those of BMA-DTPA (see 3, Omniscan) and HP-DOTA (see 4, Prohance) are neutral; their low osmolarity decreases the pain of the injections. All these agents are extracellular, and they diffuse rapidly into the interstitial space.…”

Section: Mri Contrast Agentsmentioning

confidence: 99%

Metals in Medicine

Guo

Sadler

1999

Angew. Chem. Int. Ed.

831

504

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Not only the 24 or so essential elements, but also nonessential and even radioactive elements have enormous potential for applications in medicine. In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes. Gadolinium(III) complexes can be safely injected as magnetic resonance imaging contrast agents, and ligand design allows targeting of paramagnetic ions as well as radiodiagnostic (e.g. Tc) and radiotherapeutic isotopes (e.g. Re). Manganese superoxide dismutase mimics, vanadium insulin mimics, ruthenium nitric oxide scavengers, lanthanide-based photosensitizers, and metal-targeted organic agents show exciting clinical potential.

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Section: Mri Contrast Agentsmentioning

confidence: 99%

Metals in Medicine

Guo

Sadler

1999

Angew. Chem. Int. Ed.

831

504

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“…MR angiography can be performed together with CCA, but could not replace it. It was reported that when used to image brain AVMs, it could not show small vessels and regions of slow blood flow with the same degree [10].…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography Angiography Compared to Catheter Based Angiography in Evaluation of Cerebral Arterial Aneurysm and Arteriovenous Malformation

Badr¹,

Ahmed²,

Khafaji³

et al. 2014

OJMI

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Both cerebral arterial aneurysm and arteriovenous malformation are cerebrovascular disease, which required immediate diagnosis and urgent treatment. Since the introduction of multislice CT scanners, CT angiography (CTA) has become a powerful tool for imaging the vascular system. The goal of this study is to compare catheter based angiography and CTA in the evaluation of cerebral arterial aneurysm and arteriovenous malformation AVM. A retrospective analysis of 50 patients for exploring the record of patient who underwent both multislice CT angiography (MSCTA) and catheter based angiography before treatment is presented during last one year in the department of Radiology, King Fahd Hospital-Jeddah, Kingdom of Saudi Arabia. The sensitivity of CTA for picking up aneurysm is 86% and the sensitivity of catheter based angiography for picking up aneurysm is 97%. The specificity of CTA for picking up aneurysm is (76%), the false positive cases are (3%) and the false negative cases are 10%. The sensitivity of both CTA and catheter based angiography for picking up arteriovenous malformation is (90%). The specificity of CTA for picking up AVM is (76%), the false positive cases are (10%) and no false negative cases in CTA are found. The sensitivity and specificity of catheter based angiography is 100% in diagnosis and detection of cerebral arterial aneurysm and AVM. The present study concluded that CTA has high sensitivity and specificity in detecting aneurysm and AVM enough to be chosen as the first step. Catheter based angiography, still a gold standard for radiology examination, is the most accurate, sensitive and specific method in diagnosis and detection of cerebral arterial aneurysm and arteriovenous * Corresponding author. S. M. Badr et al.118 malformation, which can be done as the second step. In addition, catheter based angiography is done for treatment planning, treatment with interventional procedure and for prognosis after treatment.

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“…11 Second, in acute stroke, MRA sequence must be short and fast to not delay the treatment and management of the patient. Several authors have proposed some strategies to improve the sensitivity of the postperfusion MRA technique, such as the infusion of higher doses of contrast, different flip angle, different TR, 11,16 and different tilt of the slab. 13 However, the present findings show that MRA after PWI with a standard dose of contrast, using the same parameters as in the classical MRA, is more helpful than preperfusion MRA, so postperfusion MRA should substitute preperfusion MRA in future studies to reduce the time consumption of the MR study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Preperfusion and Postperfusion Magnetic Resonance Angiography in Acute Stroke

Pedraza

Silva

Méndez

et al. 2004

Stroke

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Background and Purpose-The multimodal magnetic resonance imaging study in acute stroke includes perfusionweighted imaging (PWI) after administration of contrast and magnetic resonance angiography (MRA). However, MRA may overestimate the degree of vessel obstruction caused by limitations to detect low flow states. Our aim was to determine the usefulness of a new fast imaging protocol combining classical MRA, PWI, and postperfusion MRA to improve the diagnostic management in acute ischemic stroke. Methods-We studied 31 patients with a middle cerebral artery (MCA) infarction within the first 12 hours from the onset of symptoms. All patients had an MCA stenosis or occlusion. The study protocol included a preperfusion MRA and a postperfusion MRA. Modified thrombolysis in myocardial infarction (TIMI) classification was used to assess the patency of vessels. Results-In 17 patients (group A, 55%), preperfusion MRA and postperfusion MRA accorded in the estimation of vascular status, whereas in 14 patients (group B, 45%) postperfusion MRA showed a better vascular flow than preperfusion MRA. The improvement in the depiction of flow was from a complete occlusion (TIMI I) to a partial occlusion (TIMI II) in 9 patients and from TIMI II to normal patency (TIMI III) in 5 patients. Thirty-six percent of the patients with suspected internal carotid artery occlusion in the preperfusion MRA showed flow in the intracranial internal carotid artery in the postperfusion MRA. Conclusions-Postperfusion contrast-enhanced MRA can demonstrate arterial segments with low flow and avoid overestimation of vascular obstruction.

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Contrast-Enhanced Magnetic Resonance Angiography of Cerebral Arteries

Cited by 65 publications

References 38 publications

Metals in Medicine

Metals in Medicine

Computed Tomography Angiography Compared to Catheter Based Angiography in Evaluation of Cerebral Arterial Aneurysm and Arteriovenous Malformation

Comparison of Preperfusion and Postperfusion Magnetic Resonance Angiography in Acute Stroke

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