Contrast-enhanced imaging features and differentiation of benign and malignant focal splenic lesions

Cao, Fang; Qian, Wei; Ma, Yanqing; Wu, Yinbo; Zhong, Jianguo

doi:10.1016/j.clinimag.2017.10.020

Cited by 14 publications

(7 citation statements)

References 17 publications

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“…Our results indicated that CEUS not only enhances the diagnostic efficiency of detecting splenic benign and malignant lesions but also improves the reliability and repeatability of ultrasound examination. Previous studies reported that most splenic masses are benign and malignant tumors account for only 20-35%, 28,29 which is consistent with our results (40/123, 32.5%; Table 1). Among 83 benign lesions, 13 infarctions and 3 complex cysts presented nonenhancement throughout the CEUS examination.…”

Section: Discussionsupporting

confidence: 93%

Value of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Focal Splenic Lesions

Lu¹,

Xu²,

Huang³

et al. 2021

CMAR

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Purpose To identify and validate contrast-enhanced ultrasound (CEUS) features for differentiating malignant from benign splenic lesions. Patients and Methods Splenic lesions in 123 patients who underwent conventional ultrasound (B-mode US) and CEUS were included in this study. Two radiologists evaluated the sonograms of B-mode and CEUS. Statistical analysis was performed to identify significant imaging predictors for splenic malignant lesions. Two other radiologists independently reviewed B-mode and CEUS sonograms and diagnosed the lesions based on proposed criteria as 1) benign, 2) probably benign, 3) probably malignant or 4) malignant. The diagnostic efficiency between B-mode US and CEUS was compared. Results Common imaging findings of malignant lesions included hypoechoic, ill-defined margin, absence of cystic/necrotic portion, presence of splenomegaly on B-mode US, and hypoenhancement, rapid washout and presence of intralesional vessels on CEUS ( P < 0.05). Among them, three independent features were identified using multivariate logistic regression analysis: hypoechoic pattern, hypoenhancement pattern and intralesional vessels. When three of these findings were combined as a predictor for splenic malignant lesions, 22 (55.0%) of 40 malignant splenic lesions were identified with a specificity of 100%. The diagnostic performance of two readers using receiver operating characteristic curve analysis was 0.622 and 0.533, respectively, for B-mode US, which was significantly improved to 0.908 and 0.906 for CEUS ( P < 0.001). The degree of other diagnostic efficiency and inter-reader agreement also increased with CEUS compared to B-mode US. Conclusion CEUS may provide more useful information than B-mode US and improve the diagnosis efficiency for distinguishing malignant from benign splenic lesions.

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Section: Discussionsupporting

confidence: 93%

Value of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Focal Splenic Lesions

Lu¹,

Xu²,

Huang³

et al. 2021

CMAR

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“…Mild enhancement may be observed after contrast administration. MRI is more sensitive than CT and provides clearer images in the portal phase [7,8]. Calci cations in metastatic tumors of the spleen are extremely rare, except in speci c pathological types such as primary tumor splenic mucinous adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

A case report of splenic malignant tumor originating from liver

Shen,

Xu,

et al. 2023

Preprint

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Splenic tumors are infrequently encountered in clinical practice, with a metastatic tumor incidence estimated to be approximately 2%-4% of all splenic tumors. Metastatic tumors originating from the liver are even more uncommon. Given the scarcity of reported cases and limited literature on splenic tumors, particularly in recent years, clinicians face significant challenges in effectively managing this disease. In this report, we present a case of a malignant splenic tumor originating from the liver. The patient, a 58-year-old male, was admitted to our hospital over a week after the identification of a splenic mass. Notably, the patient had previously undergone liver cancer surgery at our institution two years prior. Based on the patient's clinical presentation, physical examination findings, and additional diagnostic tests, we performed a surgical procedure known as "left outer lobe resection of liver + splenectomy + cholecystectomy". The postoperative pathological analysis confirmed the presence of recurrent hepatocellular carcinoma with splenic metastasis. Combining domestic and international literature, we now report a case of splenic malignancy of hepatic origin. In this case report, we aim to present its differential diagnosis and treatment options for clinicians' reference.

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“…Although malignant splenic lesions are relatively rare in human medicine [ 17 , 84 , 85 , 86 ], in recent years, the importance of correctly diagnosing malignant lesions [ 84 , 87 , 88 , 89 , 90 ], together with the risk of hemorrhage, immune system impairment, and sepsis associated with invasive procedures [ 84 , 89 ] has propelled research into the use of contrast-enhanced ultrasonography to differentiate between malignant and benign lesions in human medicine [ 69 , 88 , 91 ]. In veterinary medicine, neoplastic splenic lesions are much more common [ 92 , 93 ] and not easily differentiated from benign processes through normal imaging techniques [ 75 , 76 , 77 ].…”

Section: Ceus-detected Spleen Abnormalities In Dogs and Catsmentioning

confidence: 99%

Applications of Contrast-Enhanced Ultrasound in Splenic Studies of Dogs and Cats

Canejo-Teixeira

Lima

Santana

2022

Animals

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Contrast-enhanced ultrasound (CEUS) is an emerging technology in veterinary medicine involving the administration of intravenous contrast agents, and it is increasingly recognized for its high potential as a diagnostic imaging tool for small animals. This exam is easy and quick to perform, safe and reliable, and allows for the differentiation of lesions. It permits the identification of lesions that may require more invasive procedures, from those that can be safely dismissed to those that can be followed-up with ultrasound imaging. Although it has been extensively reviewed for use in human medicine, there is an overall lack of information about the application of this technique for cats and dogs, particularly in splenic studies, which can be particularly important for small animals. The present review describes and summarizes the CEUS applications used for splenic analysis in cats and dogs, providing a basic overview of CEUS technology with examples of common and uncommon features of focal splenic lesions. It also systematically gathers the results obtained for benign and malignant splenic lesions described in the literature, whilst providing guidelines for their interpretation. Furthermore, it presents the advantages of using CEUS for splenic analysis in cats and dogs and the main factors that may influence the quality of the imaging and the accuracy of the diagnosis. This type of knowledge can be used to provide a framework to help veterinarians make informed decisions regarding the use of this emerging technique for splenic lesions, guiding their interpretation of CEUS findings in the splenic ultrasounds of cats and dogs.

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Contrast-enhanced imaging features and differentiation of benign and malignant focal splenic lesions

Cited by 14 publications

References 17 publications

Value of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Focal Splenic Lesions

Value of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Focal Splenic Lesions

A case report of splenic malignant tumor originating from liver

Applications of Contrast-Enhanced Ultrasound in Splenic Studies of Dogs and Cats

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