Contrast agent induced thrombophlebitis following leg phlebography: iopamidol versus meglumine iothalamate

Thomas, Martyn; Keeling, F; Piaggio, R. B.; Treweeke, P. S.

doi:10.1259/0007-1285-57-675-205

Cited by 26 publications

(2 citation statements)

References 8 publications

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“…101,103 However, the physiologic status of individual patients and predisposing factors contribute significantly to the overall severity of the observed adverse reactions. 112,113,132,134,191,199,200 For example, patients with parapro teinemia are very susceptible to the effects of con trast agents, with severe renal failure being observed in these patients. 151 Similarly, patients with sickle cell disease and polycythemia vera exhibit severe rheologic disturbances after contrast media infu sion.…”

Section: Fig 23 Reactions To Contrast Media and Their Manage Mentmentioning

confidence: 99%

Molecular Markers of Contrast Media-Induced Adverse Reactions

Fareed¹,

Moncada²,

Messmore³

et al. 1984

Semin Thromb Hemost

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Currently used routine laboratory screening methods are not reliable in the prediction of contrast media-related adverse reactions. Cost-effective laboratory methods for various molecular markers of pathophysiologic activation have now become available. In vitro activation tests in high-risk patients may prove to be useful in the prediction of contrast-induced activation of various adverse reactions. If prior clinical evaluation of a patient suggests an ongoing pathologic process, profiling of the following molecular markers may prove to be useful and helpful in avoiding contrast-induced adverse reactions: Fibrinopeptide A, platelet factor 4, thromboxane B2, 5-HETE, physiologic inhibitors of proteases, B beta 15-42 related peptides, bradykinin/kininogen, and anaphylactozins. In patients suspected of reacting to contrast agents, a small dose of 1 to 5 ml can be injected as a bolus and molecular marker profiling on blood drawn after the infusion may prove to be useful screening tests. Additional clinical studies are needed to prove this. However, this screening test should be performed with extreme caution, since some of the patients are known to react to as little as 1 ml dose. The safety of newly developed nonionic contrast agents can be readily assessed by profiling various molecular markers of adverse reactions, which provide a more reliable and quantitative assessment of contrast-induced adverse reactions. Based on molecular marker profiling, various prophylactic agents can be given to high-risk patients to avoid contrast-induced adverse reactions.

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Section: Fig 23 Reactions To Contrast Media and Their Manage Mentmentioning

confidence: 99%

Molecular Markers of Contrast Media-Induced Adverse Reactions

Fareed¹,

Moncada²,

Messmore³

et al. 1984

Semin Thromb Hemost

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“…The present series is far too small to make assessment with regard to ioversol. Pre-clinical studies suggest that the toxicity of ioversol will be comparable with other non-ionic agents (Adams et a1 1984, Ralston et a1 1989.…”

Section: Discussionmentioning

confidence: 99%

Ioversol in Ascending Phlebography — A Clinical Trial

Scott¹,

Palmer²

1990

Australasian Radiology

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In this controlled randomised double-blind parallel group study of the use of ioversol-240 and ioversol-320 in venography all studies were considered diagnostic with comparable quality in the two groups. Patient tolerance was high with mild heat observed in 7 patients in the ioversol-320 group and 1 patient in the ioversol-240 group. Assessment of pain was also comparable (2 patients in the ioversol-240 group and 1 in the ioversol-320 group). Both strengths of the contrast agent produced no clinically significant, drug related, changes in vital signs or laboratory parameters and there were no significant clinical adverse reactions.

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Thromboembolism

Swiet¹

2002

Medical Disorders in Obstetric Practice

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Contrast agent induced thrombophlebitis following leg phlebography: iopamidol versus meglumine iothalamate

Cited by 26 publications

References 8 publications

Molecular Markers of Contrast Media-Induced Adverse Reactions

Molecular Markers of Contrast Media-Induced Adverse Reactions

Ioversol in Ascending Phlebography — A Clinical Trial

Thromboembolism

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