Thromboembolism

Swiet, Michael de

doi:10.1002/9780470752371.ch4

Cited by 10 publications

(13 citation statements)

References 253 publications

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“…Approximately 12% of this study population were from the Indian subcontinent. A review in 1985 found that pregnancy related venous thromboembolism was extremely rare in Africa and the Far East, and a low prevalence was found in Chinese women, which could have been related to the increase in protein level C at the end of pregnancy 6 .…”

Section: Discussionmentioning

confidence: 99%

“…ICD9 Embolism and thrombosis of the renal vein I63. 6 Cerebral infarction due to cerebral venous thrombosis, non-pyogenic I67. 6 Non-pyogenic thrombosis of intracranial venous system O87.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary embolism is the leading cause of direct maternal deaths in the UK 4 . The incidence of venous thromboembolism during pregnancy and the puerperium has been estimated to be 5.5 ± 6 times higher than in general female population of childbearing age 5,6 . A recent study in Denmark found the incidence rate of venous thromboembolism during pregnancy to be 85/100,000 maternities based on 54 cases 7 .…”

Section: Introductionmentioning

confidence: 95%

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Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database

Simpson¹,

Lawrenson²,

Nightingale³

et al. 2001

British Journal of Obstetrics and Gynaecology

168

138

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Objective To determine the incidence of venous thromboembolism in pregnancy and the puerperium and to identify risk factors for pregnancy-related venous thromboembolism.Design Cohort study and case±control study.Setting London, UK.Population 395,335 women with live births or pregnancies of 24 or more weeks of gestation between 1988 and 1997.Methods Data extraction from the St Mary's Maternity Information System database. Random sample of 5% for case±control study.Main outcome measures Incidence of venous thromboembolism; odds ratios for variables associated with venous thromboembolism. ResultsThe incidence of venous thromboembolism was 85/100,000 maternities. There were approximately twice as many postpartum as antepartum events. Blood group A, multiple pregnancy, caesarean section, cardiac disease, delivery at gestational age of ,36 weeks, a body mass index of $25, or more and maternal age of 35 or over were all found to increase incidence of venous thromboembolism. Conclusions Although venous thromboembolism is the leading cause of maternal deaths in the UK, it is still a rare event. Most of these events are deep vein thromboses occurring in the postpartum period. Antenatally multiple birth is an important risk factor. Postnatally women who have had a caesarean section, premature delivery or history of cardiac disease should be assessed carefully for venous thromboembolism.

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Section: Discussionmentioning

confidence: 99%

“…ICD9 Embolism and thrombosis of the renal vein I63. 6 Cerebral infarction due to cerebral venous thrombosis, non-pyogenic I67. 6 Non-pyogenic thrombosis of intracranial venous system O87.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database

Simpson¹,

Lawrenson²,

Nightingale³

et al. 2001

British Journal of Obstetrics and Gynaecology

168

138

View full text Add to dashboard Cite

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“…It may be genetically determined, acquired, or both. 1 Thrombophilia, which involves interactions between inherited and acquired risk factors, has been suggested as a possible cause of recurrent spontaneous abortions. 2 The most common types of hereditary thrombophilia are factor V leiden (FVL), prothrombin (PTH), and methylenetetrahydrofolate reductase (MTHFR) genes mutations, but these are usually undiagnosed because most carriers are asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

Clinical and etiological profile of unprovoked thrombosis in young patients admitted at a tertiary care hospital

Ahmad¹,

Akhter²,

Sheikh³

2017

Int J Res Med Sci

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Background: It is now possible to identify acquired and hereditary risk factors in a substantial percentage of patients presenting with a venous thrombotic event. The objective of the study was to study the clinical and etiological profile of patients with unprovoked thrombosis in young patients.Methods: Twenty-one patients 09 males (42.8%) and 12 females (57.14%) with a mean age of 29.67±5.21 were studied, who presented with unprovoked thrombosis.Results: Among 21 patients studied most common presentation was deep venous thrombosis of lower limbs (38.09%) followed by recurrent abortions with deep venous thrombosis (14.28%) and cerebellar infarction (14.28%). In etiological profile, the most common thrombophilla was factor V Leiden mutation (28.57%) followed by antiphospholipid antibody syndrome (23.8%), protein C deficiency (19.04%), methylene tetrahydrofolate reductase (9.52%) and antithrombin, prothrombin gene mutation, hyperhomocystenemia and janus kinase 2 mutations (4.76%). Among 6 patients of factor V Leiden mutation 3 presented with deep venous thrombosis of lower limbs, 1 patient each with middle cerebral artery infarct, juglar vein thrombosis and subclavian vein thrombosis respectively.Conclusions: Factor V Leiden mutation is the most common inherited thrombophillias which has been "substantiated from various studies.

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“…The risk of thromboembolism is manyfold in pregnancies as well as preeclampsia [4]. The level of coagulation factors [5] and suppression of fibrinolytic activities [6] are pronounced in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Blood Coagulation and Fibrinolysis in Eclamptic Patients and Their Correlation with the Clinical Signs

Halim

Bhuiyan²,

Azim

et al. 1995

Gynecol Obstet Invest

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We studied the impact of blood coagulation and fibrinolysis on the clinical features of eclamptic patients (n = 20) in Bangladesh. The variables used were edema, proteinuria, blood pressure, number of convulsions, level of consciousness at the time of admission, thrombin antithrombin complexes (TAT), antithrombin (AT) III (%) activity and antigen, D dimer fibrin degradation product and Α₂-plasmin inhibitor-plasmin complex (PIC) in plasma. Canonical correlation analysis was made to obtain clinical index, eclampsia index and two coagulation indices. On admission, the mean values of coagulation parameters were AT III activity: 83.2% (range 57–108), TAT complex: 47.6 ng/ml (range 11.5–60), D dimer: 1,693 ng/ml (range 417–8,276) and PIC 1.4mg/ml (range 0.4–3.3). We found a significant correlation between the eclampsia index and clinical index (r = 0.601; p = 0.01). Gestosis index, clinical index, and eclampsia index have also a strong correlation with the coagulation index (r = 0.695, p < 0.005; r = 0.871, p < 0.0001 and r = 0.805, p < 0.0001, respectively). Coagulation and fibrinolysis were markedly activated in eclampsia. The correlation between the clinical status and coagulation status in this study suggested a close relation between the coagulation and the development and progression of the disease.

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Thromboembolism

Cited by 10 publications

References 253 publications

Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database

Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database

Clinical and etiological profile of unprovoked thrombosis in young patients admitted at a tertiary care hospital

Blood Coagulation and Fibrinolysis in Eclamptic Patients and Their Correlation with the Clinical Signs

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