Contraction‐induced changes in skeletal muscle Na+,K+ pump mRNA expression – importance of exercise intensity and Ca2+‐mediated signalling

Nordsborg, Nikolai Baastrup; Kusuhara, Keiko; Hellsten, Ylva; Lyngby, Stine Secher; Lundby, Carsten; Madsen, Klavs; Pilegaard, Henriette

doi:10.1111/j.1748-1716.2009.02057.x

Cited by 23 publications

(44 citation statements)

References 26 publications

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“…Despite the fact that these results partially agreed with those of some authors who observed significant increases in plasma K levels during a short-term progressive resistance dynamic exercise in healthy males [34], others have observed no changes in K and Cl after a 20-miles run in experienced marathon runners with a 5% of body mass lost [35]. Therefore, all these results may suggest that the release of K from muscle to plasma during exercise is more related to Na + -K + -ATPase enzyme training adaptation [36] than to P osm level. Finally, in the present study, plasma Cl levels increased.…”

Section: Discussionsupporting

confidence: 90%

Plasma trace elements levels are not altered by submaximal exercise intensities in well-trained endurance euhydrated athletes

González-Haro

Soria

López-Colón

et al. 2011

Journal of Trace Elements in Medicine and Biology

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Section: Discussionsupporting

confidence: 90%

Plasma trace elements levels are not altered by submaximal exercise intensities in well-trained endurance euhydrated athletes

González-Haro

Soria

López-Colón

et al. 2011

Journal of Trace Elements in Medicine and Biology

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“…It is also plausible that Ca 2+ -protein interactions may indirectly affect muscle function. Increased intracellular [Ca 2+ ] increases the expression of Na + /K + ATPase α1 mRNA through the calcineurin and CAM kinase II signaling pathways in rat skeletal muscle oxidative fibers (Nordsborg et al, 2010). Redox changes to intra-sarcoplasmic reticulum proteins suggest that ROS could affect Ca 2+ signaling following sustained hypoxia (Lewis et al, 2016).…”

Section: Could Calcium Be Key? Ca2+ Release and The Sarcomere In The mentioning

confidence: 99%

Diaphragm Muscle Adaptation to Sustained Hypoxia: Lessons from Animal Models with Relevance to High Altitude and Chronic Respiratory Diseases

Lewis

O’Halloran

2016

Front. Physiol.

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The diaphragm is the primary inspiratory pump muscle of breathing. Notwithstanding its critical role in pulmonary ventilation, the diaphragm like other striated muscles is malleable in response to physiological and pathophysiological stressors, with potential implications for the maintenance of respiratory homeostasis. This review considers hypoxic adaptation of the diaphragm muscle, with a focus on functional, structural, and metabolic remodeling relevant to conditions such as high altitude and chronic respiratory disease. On the basis of emerging data in animal models, we posit that hypoxia is a significant driver of respiratory muscle plasticity, with evidence suggestive of both compensatory and deleterious adaptations in conditions of sustained exposure to low oxygen. Cellular strategies driving diaphragm remodeling during exposure to sustained hypoxia appear to confer hypoxic tolerance at the expense of peak force-generating capacity, a key functional parameter that correlates with patient morbidity and mortality. Changes include, but are not limited to: redox-dependent activation of hypoxia-inducible factor (HIF) and MAP kinases; time-dependent carbonylation of key metabolic and functional proteins; decreased mitochondrial respiration; activation of atrophic signaling and increased proteolysis; and altered functional performance. Diaphragm muscle weakness may be a signature effect of sustained hypoxic exposure. We discuss the putative role of reactive oxygen species as mediators of both advantageous and disadvantageous adaptations of diaphragm muscle to sustained hypoxia, and the role of antioxidants in mitigating adverse effects of chronic hypoxic stress on respiratory muscle function.

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“…According to experiments by Nordsborg et al (2010), exercise-induced increases in Na (+), K (+) pump alpha1 and beta1 mRNA expression in trained subjects are more pronounced after highthan after moderate-and low-intensity exercise, and Ca 2+ regulates alpha1 mRNA expression in oxidative muscles via Ca (2+) / calmodulindependent protein kinase (CaMK) and calcineurin signalling pathways (7). In an investigation on the causal link between the limitation of myofibre transitions and modulation of calcineurin activity, an exercise of both high frequency and amplitude (swimming) or low frequency and amplitude (running) can induce an initial activation followed by the inhibition of calcineurin (8).…”

Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphisms within Calcineurin-Encoding Genes are Associated with Response to Aerobic Training in Han Chinese Males

Liu

et al. 2016

Ann. Appl. Sport Sci.

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Calcineurin, which functions in calcium signaling, is expressed in skeletal and cardiac muscle and has been linked to sensitivity to muscle strength training. It is also proposed to contribute to individual aerobic endurance. To investigate the relationship between calcineurin-encoding genes and aerobic endurance traits, 126 young-adult Han Chinese males were enrolled in an aerobic exercise training study. Participants were genotyped for polymorphisms within the 5 genes (PPP3CA, PPP3CB, PPP3CC, PPP3R1 and PPP3R2) encoding calcineurin using restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) or matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Participants underwent 18 weeks of aerobic exercise training (running). Before and after the training period, maximal oxygen uptake (VO2max) and 12 km/h running economy were measured. Statistical analyses were performed using chi-square test and analysis of variance. The baseline value of VO2max was significantly associated with rs3804423 and rs2850965 loci in the PPP3CA gene (P<0.05). The training responsiveness of VO2max was significantly associated with the rs3804358 locus in PPP3CA and the rs4671887 locus in PPP3R1 (P<0.05). The training responsiveness of running economy was significantly associated with rs3739723 in PPP3R2 (P<0.05). These findings indicate that polymorphisms within the calcineurin-encoding genes may partially explain individual differences in response to aerobic training.

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Contraction‐induced changes in skeletal muscle Na⁺,K⁺ pump mRNA expression – importance of exercise intensity and Ca²⁺‐mediated signalling

Cited by 23 publications

References 26 publications

Plasma trace elements levels are not altered by submaximal exercise intensities in well-trained endurance euhydrated athletes

Plasma trace elements levels are not altered by submaximal exercise intensities in well-trained endurance euhydrated athletes

Diaphragm Muscle Adaptation to Sustained Hypoxia: Lessons from Animal Models with Relevance to High Altitude and Chronic Respiratory Diseases

Single Nucleotide Polymorphisms within Calcineurin-Encoding Genes are Associated with Response to Aerobic Training in Han Chinese Males

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