Contractile function in canine right ventricle

Meier, G. D.; Bové, Alfred A.; Santamore, William P.; Lynch, Peter R.

doi:10.1152/ajpheart.1980.239.6.h794

Cited by 53 publications

(53 citation statements)

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“…The amount of maximum strain measured (on average about 17%) was similar to previously measured RV strains in the conscious dog, 3,18,23 despite the substantially slowed heart rate in the anesthetized mouse in this study (250 bpm) compared with a conscious mouse (500-600 bpm). The literature contains conflicting results regarding regional strain differences.…”

Section: Regional Systolic Functionsupporting

confidence: 86%

“…We found that strains were somewhat lower in the sinus region than the outflow tract region, which is consistent with some previous studies, 3,21 but disagrees with others. 18,27 The reasons for these discrepancies are not clear, but are likely due to differences in preparation such as in marker placement and open-vs. closed-chest measurements. RV pressure has been measured frequently in mice using similar methods in recent years, and developed pressures ranged between 8 and 30 mmHg, 6,29 possibly depending on the type and amount of anesthetic used.…”

Section: Regional Systolic Functionmentioning

confidence: 99%

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Deficiency of Actinin-Associated LIM Protein Alters Regional Right Ventricular Function and Hypertrophic Remodeling

2005

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Targeted deletion of actinin-associated LIM protein (ALP) in mice leads to right ventricular (RV) dysplasia and a mild RV cardiomyopathy. Although the phenotype has been thoroughly characterized, the mechanisms leading from the cytoskeletal defect to the disease are unclear. We hypothesized that ALP deficiency may be associated with (1) changes in regional systolic dysfunction and (2) regional dysregulation of hypertrophic growth, in accordance with the restricted expression of ALP in the outflow tract of the RV. We examined RV regional epicardial systolic strains with respect to end-diastole in ALP knockout (ALPKO) mice and wild-type controls using an open-chest preparation. Strain components were consistently lower in the ALPKO mice than wild-type controls (second principal strain E 2 : p = 0.05). RV pressure was slightly but not significantly lower in ALPKO mice as well. To assess regional growth, geometric remodeling was analyzed in ALPKO and wild-type mice after 4 weeks of chronic hypoxia (11% oxygen). The average amount of RV wall thickening in response to hypoxia was reduced to 11% in the ALPKO mice compared with 44% in the wild-type controls. In summary, the results are consistent with the view that disruption of ALP is associated with diminished RV contractile function as well as altered hypertrophic remodeling.

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Section: Regional Systolic Functionsupporting

confidence: 86%

Section: Regional Systolic Functionmentioning

confidence: 99%

Deficiency of Actinin-Associated LIM Protein Alters Regional Right Ventricular Function and Hypertrophic Remodeling

2005

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“…28 26 Our results provide evidence that segment shortening is affected differently by acute pulmonary microembolisation in right ventricular inflow and outflow tracts. While shortening was not affected in the inflow tract, it decreased in the outflow tract.…”

Section: Segment Shorteningmentioning

confidence: 60%

Acute pulmonary microembolism induces different regional changes in preload and contraction pattern in canine right ventricle

Zwißler¹,

Forst²,

Meßmer³

1990

Cardiovascular Research

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Correspondence Letters containing critical assessments of material published in Cardiovascular Research, including reviews, will be considered for publication. They should be sent to the Editor within 6 months of the appearance of the article concerned.Rapid publication Short papers will be considered for rapid publication (within 3 months). These should contain material which merits accelerated publication and must not occupy more than 4 journal pages, including tables, figures and references (authors are responsible for assessing the length accurately before submission). Current standard section headings should be used. Abstracts should not exceed 100 words, and there should not be more than 10 references. Papers submitted for rapid publication should be clearly marked as such. Rejection does not preclude resubmission as a full paper. No proofs will be sent, so the submitted copy must be entirely correct.Instructions to authors. These are printed in full annually in the January issue. The following should act as a guide, but authors are urged to consult the full instructions as papers that do not comply will be returned for revision.SI Units All units of measurement, except for blood pressures, should be in SI (including those in the figures). Blood pressures should be expressed in mm Hg.References should be typed (double spacing) on separate sheets. Contributors are responsible for the accuracy of their references.

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“…One-dimensional relative motion data has been gathered by tracking pairs of radiopaque beads tracked with biplane cineradiography [30,51) or pairs of crystals with ultrasound [28]. By implanting several markers close together on the same ventricular surface (e.g., endocardium), researchers have been able to derive biaxial, or in-plane, deformations [17,6,341. The human RV has been studied using the noninvasive MRI tissue tagging method.…”

Section: Related Workmentioning

confidence: 99%

Three-dimensional motion reconstruction and analysis of the right ventricle using tagged MRI

Haber

Metaxas

Axel

2000

Medical Image Analysis

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Right ventricular (RV) dysfunction can serve as an indicator of heart and lung disease and can adversely affect the left ventricle (LV). However, normal RV function must be characterized before abnormal states can be detected. We can describe a method for reconstructing the 3D motion of the RV images by fitting of a deformable model to extracted tag and contour data from multiview tagged magnetic resonance images(MRI). The deformable model is a biventricular finite element mesh built directly from the contours. Our approach accommodates the geometrically complex RV by using the entire lengths of the tags, localized degrees of freedom (DOFs), and finite elements for geometric modeling. We convert the results of the reconstruction into potentially useful motion variables, such as strains and displacements. The fitting technique is applied to synthetic data, two normal hearts, and a heart with right ventricular hypertrophy (RVH). The results in this paper are limited to the RV free wall and septum. We find noticeable differences between the motion variables calculated for the normal volunteers and the RVH patient. AbstractRight ventricular (RV) dysfunction can serve as an indicator of heart and lung disease and can adversely affect the left ventricle (LV). However, normal RV function must be characterized before abnormal states can be detected. We describe a method for reconstructing the 3D motion of the RV images by fitting of a deformable model to extracted tag and contour data from multiview tagged magnetic resonance images (MRI). The deformable model is a biventricular finite element mesh built directly from the contours. Our approach accommodates the geometrically complex RV by using the entire lengths of the tags, localized degrees of freedom (DOFs), and finite elements for geometric modeling. We convert the results of the reconstruction into potentially useful motion variables, such as strains and displacements. The fitting technique is applied to synthetic data, two normal hearts, and a heart with right ventricular hypertrophy (RVH). The results in this paper are limited to the RV free wall and septum. We find noticeable differences between the motion variables calculated for the normal volunteers and the RVH patient.

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Contractile function in canine right ventricle

Cited by 53 publications

References 0 publications

Deficiency of Actinin-Associated LIM Protein Alters Regional Right Ventricular Function and Hypertrophic Remodeling

Deficiency of Actinin-Associated LIM Protein Alters Regional Right Ventricular Function and Hypertrophic Remodeling

Acute pulmonary microembolism induces different regional changes in preload and contraction pattern in canine right ventricle

Three-dimensional motion reconstruction and analysis of the right ventricle using tagged MRI

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