Continuous theta-burst stimulation may improve visuospatial neglect via modulating the attention network: a randomized controlled study

Fu, Wei; Cao, Lei; Zhang, Yanming; Huo, Su; Du, Jing; Zhu, Lin; Song, Weiqun

doi:10.1080/10749357.2016.1253139

Cited by 21 publications

(37 citation statements)

References 34 publications

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“…We excluded 15 studies for the following reasons: case report, case series, self-controlled study, review, and off-topic. The remaining 12 RCTs [ 14 , 50 – 60 ] with a total of 273 participants and four non-RCTs [ 61 – 64 ] with a total of 94 participants met the minimum requirements, and we included them in this review.…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 describes study characteristics related to design of study, setting, number of participants, mean age, gender, inclusion and exclusion criteria, and follow-up. Eight studies [ 14 , 54 , 56 , 59 , 61 – 64 ] were conducted largely in Europe and eight in Asia [ 50 – 53 , 55 , 57 , 58 , 60 ]. Randomized trials' sample sizes ranged from 10 [ 56 ] to 38 [ 55 ], and non-RCT studies ranged from 12 [ 63 ] to 36 [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

“…Table 3 describes study characteristics related to intervention and comparators and assessed outcomes. Of the 16 included studies, nine trials [ 14 , 50 , 52 , 54 , 55 , 59 – 62 ] evaluated TBS: Eight trials compared cTBS versus sham cTBS (both groups received conventional rehabilitation training [ 52 , 60 ]); 1 Hz rTMS, 10 Hz rTMS, and sham rTMS (all groups with addition of routine rehabilitation [ 55 ]); sham TBS [ 14 ]; sham cTBS [ 54 , 59 , 61 , 62 ]. One trial compared iTBS with 80% resting motor threshold (RMT) versus iTBS 40% RMT [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

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Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

Kashiwagi

Dib

Gomaa³

et al. 2018

Neural Plasticity

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Background Unilateral spatial neglect (USN) is the most frequent perceptual disorder after stroke. Noninvasive brain stimulation (NIBS) is a tool that has been used in the rehabilitation process to modify cortical excitability and improve perception and functional capacity. Objective To assess the impact of NIBS on USN after stroke. Methods An extensive search was conducted up to July 2016. Studies were selected if they were controlled and noncontrolled trials examining transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and theta burst stimulation (TBS) in USN after stroke, with outcomes measured by standardized USN and functional tests. Results Twelve RCTs (273 participants) and 4 non-RCTs (94 participants) proved eligible. We observed a benefit in overall USN measured by the line bisection test with NIBS in comparison to sham (SMD −2.35, 95% CI −3.72, −0.98; p = 0.0001); the rTMS yielded results that were consistent with the overall meta-analysis (SMD −2.82, 95% CI −3.66, −1.98; p = 0.09). The rTMS compared with sham also suggested a benefit in overall USN measured by Motor-Free Visual Perception Test at both 1 Hz (SMD 1.46, 95% CI 0.73, 2.20; p < 0.0001) and 10 Hz (SMD 1.19, 95% CI 0.48, 1.89; p = 0.54). There was also a benefit in overall USN measured by Albert's test and the line crossing test with 1 Hz rTMS compared to sham (SMD 2.04, 95% CI 1.14, 2.95; p < 0.0001). Conclusions The results suggest a benefit of NIBS on overall USN, and we conclude that rTMS is more efficacious compared to sham for USN after stroke.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

Kashiwagi

Dib

Gomaa³

et al. 2018

Neural Plasticity

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“…Furthermore, two RCT-studies corroborated the above outcomes. 111,112 In recent years, researchers have also successfully applied inhibitory continuous Theta Burst Stimulation (cTBS) to the healthy hemisphere of individuals with USN in NRCT, 113,114 as well as in RCT-studies [115][116][117][118] observing long-lasting improved performance. Interestingly, Yang and colleagues 119 conducted a RCT study to compare behavioural and brain plasticity effects in USN individuals undergoing low-frequency rTMS, high-frequency rTMS, or cTBS.…”

Section: Transcranial Magnetic Stimulation (Tms)mentioning

confidence: 99%

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Gammeri¹,

Iacono²,

Ricci

et al. 2020

NDT

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Introduction: Unilateral spatial neglect (USN) is a disorder of contralesional space awareness which often follows unilateral brain lesion. Since USN impairs awareness of contralesional space/body and often of concomitant motor disorders, its presence represents a negative prognostic factor of functional recovery. Thus, the disorder needs to be carefully diagnosed and treated. Here, we attempted to present a clear and concise picture of current insights in the comprehension and rehabilitation of USN. Methods: We first provided an updated overview of USN clinical and neuroanatomical features and then highlighted recent progresses in the diagnosis and rehabilitation of the disease. In relation to USN rehabilitation, we conducted a MEDLINE literature research on three of the most promising interventions for USN rehabilitation: prismatic adaptation (PA), non-invasive brain stimulation (NIBS), and virtual reality (VR). The identified studies were classified according to the strength of their methods. Results: The last years have witnessed a relative decrement of interest in the study of neuropsychological disorders of spatial awareness in USN, but a relative increase in the study of potential interventions for its rehabilitation. Although optimal protocols still need to be defined, high-quality studies have demonstrated the efficacy of PA, TMS and tDCS interventions for the treatment of USN. In addition, preliminary investigations are suggesting the potentials of GVS and VR approaches for USN rehabilitation. Conclusion: Advancing neuropsychological and neuroscience tools to investigate USN pathophysiology is a necessary step to identify effective rehabilitation treatments and to foster our understanding of neurofunctional bases of spatial cognition in the healthy brain.

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“…combined with rsfMRI has been used to study the default mode network(Abellaneda-Perez et al, 2019;Shang et al, 2019), attention(Anderkova et al, 2018), visualspatial neglect(Fu et al, 2017), cerebellar connectivity(Rastogi et al, 2017), mental illness,(Baeken, Duprat, Wu, De Raedt, & van Heeringen, 2017) and memory in humans(Mancini et al, 2017). These studies show that measuring transient TBS induced disruption with rsfMRI offers a systematic experimental methodology for extending more than two hundred years of neuropsychological research.…”

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confidence: 99%

Thetaburst TMS to the posterior superior temporal sulcus decreases resting-state fMRI connectivity across the face processing network

Handwerker

Ianni

Gutiérrez

et al. 2019

Preprint

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AbstractHumans process faces using a network of face-selective regions distributed across the brain. Neuropsychological patient studies demonstrate that focal damage to nodes in this network can impair face recognition, but such patients are rare. We approximated the effects of damage to the face network in neurologically normal human participants using thetaburst transcranial magnetic stimulation (TBS). Multi-echo functional magnetic resonance imaging (fMRI) resting-state data were collected pre- and post-TBS delivery over the face-selective right superior temporal sulcus (rpSTS), or a control site in the right motor cortex. Results showed that TBS delivered over the rpSTS reduced resting-state connectivity across the extended face-processing network. This connectivity reduction was observed not only between the rpSTS and other face-selective areas, but also between non-stimulated face-selective areas across the ventral, medial and lateral brain surfaces (e.g. between the right amygdala and bilateral fusiform face areas and occipital face areas). TBS delivered over the motor cortex did not produce significant changes in resting-state connectivity across the face-processing network. These results demonstrate that, even without task-induced fMRI signal changes, disrupting a single node in a brain network can decrease the functional connectivity between nodes in that network that have not been directly stimulated.Author SummaryHuman behavior is dependent on brain networks that perform different cognitive functions. We combined thetaburst transcranial magnetic stimulation (TBS) with resting-state fMRI to study the face processing network. Disruption of the face-selective right posterior superior temporal sulcus (rpSTS) reduced fMRI connectivity across the face network. This impairment in connectivity was observed not only between the rpSTS and other face-selective areas, but also between non-stimulated face-selective areas on the ventral and medial brain surfaces (e.g. between the right amygdala and bilateral fusiform face areas and occipital face areas). Thus, combined TBS/fMRI can be used to approximate and measure the effects of focal brain damage on brain networks, and suggests such an approach may be useful for mapping intrinsic network organization.Technical TermsTBS vs TMSTranscranial magnetic stimulation (TMS) is a method that induces current in neural tissue by using a rapidly changing magnetic field. The pattern of magnetic field changes can vary. Thetaburst TMS (TBS) is a type of TMS where the same stimulation pattern fluctuates at around a 5Hz cycle.Multi-echo fMRIDuring typical fMRI, protons are excited and there is a delay, the echo time, before data are collected. That delay is typically designed to result in a high contrast for blood oxygenation differences. In multi-echo fMRI, data are collected at several echo times each time protons are excited. This results in data that have different levels of contrast for blood oxygenation differences. This added information can be used to empirically decrease noise.Face networkA group of brain regions that show significant activity changes in response to visual face stimuli. While these regions have been defined using univariate analyses with task-based fMRI, they often significantly correlate with each other at rest. In this manuscript, the following regions were a priori defined as part of the face network: posterior superior temporal sulcus (pSTS), amygdala, fusiform face area (FFA), and occipital face area (OFA).Matrix based analysis (MBA)A recent approach that uses a Bayesian multilevel modeling framework to identify pairs of ROIs where a decrease in correlation magnitude was larger than expected along with a measure of statistical evidence. With this approach, correlations between all pairs of ROIs are assessed as part of a single model rather than many independent statistical tests.

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Continuous theta-burst stimulation may improve visuospatial neglect via modulating the attention network: a randomized controlled study

Cited by 21 publications

References 34 publications

Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Thetaburst TMS to the posterior superior temporal sulcus decreases resting-state fMRI connectivity across the face processing network

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