Continuous theta-burst rTMS over primary somatosensory cortex modulates tactile perception on the hand

Rai, Navjot; Premji, Azra; Tommerdahl, Mark; Nelson, Aimee J.

doi:10.1016/j.clinph.2011.09.026

Cited by 36 publications

(35 citation statements)

References 71 publications

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“…We demonstrate their feasibility in healthy adults (HA) and typically developing children (TDC), a prerequisite for future clinical studies, and present normative results. We present these data in the context of previous work in the field (Puts et al, 2011; Tannan et al, 2007a, 2007b; Tommerdahl et al, 2008b; Zhang et al, 2011) (Lee et al, 2012; Nelson et al, 2012; Nguyen et al, 2013a, 2013b; Rai et al, 2012) to compare the performance of children and adults and to investigate patterns of performance. A priori, we would expect absolute levels of performance to differ between the HA and TDC but the relationships between related tasks to be preserved.…”

Section: Introductionmentioning

confidence: 99%

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

Puts

Edden

Wodka

et al. 2013

Journal of Neuroscience Methods

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The cortical dynamics of somatosensory processing can be investigated using vibrotactile psychophysics. It has been suggested that different vibrotactile paradigms target different cortical mechanisms, and a number of recent studies have established links between somatosensory cortical function and measurable aspects of behavior. The relationship between cortical mechanisms and sensory function is particularly relevant with respect to developmental disorders in which altered inhibitory processing has been postulated, such as in ASD and ADHD. In this study, a vibrotactile battery consisting of nine tasks (incorporating reaction time, detection threshold, and amplitude- and frequency discrimination) was applied to a cohort of healthy adults and a cohort of typically developing children to assess the feasibility of such a vibrotactile battery in both cohorts, and the performance between children and adults was compared. These results showed that children and adults were both able to perform these tasks with a similar performance, although the children were slightly less sensitive in frequency discrimination. Performance within different task-groups clustered together in adults, providing further evidence that these tasks tap into different cortical mechanisms, which is also discussed. This clustering was not observed in children, which may be potentially indicative of development and a greater variability. In conclusion, in this study, we showed that both children and adults were able to perform an extensive vibrotactile battery, and we showed the feasibility of applying this battery to other (e.g., neurodevelopmental) cohorts to probe different cortical mechanisms.

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Section: Introductionmentioning

confidence: 99%

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

Puts

Edden

Wodka

et al. 2013

Journal of Neuroscience Methods

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“…Previous studies observed impairments in TDT for 5 to 18 minutes following cTBS over SI [6,9]. Such impairments in TDT are not observed when cTBS was applied to the dorsal lateral prefrontal cortex or lateral cerebellum [6].…”

Section: Introductionmentioning

confidence: 98%

“…In focal hand dystonia, functional [1] and anatomical abnormalities in SI [11,12] are present. These individuals also demonstrate impaired temporal discrimination threshold (TDT), which is defined as the ability to detect the presence of one versus two stimuli when the pair is delivered over the skin and separated by a varied time interval [9,13-15]. TDT impairments are greatest when lesions affect SI compared to the frontal, temporal and occipital cortex [15].…”

Section: Introductionmentioning

confidence: 99%

“…Such impairments in TDT are not observed when cTBS was applied to the dorsal lateral prefrontal cortex or lateral cerebellum [6]. Similarly, tactile two-point discrimination is also impaired for up to 18 minutes following stimulation over SI [9]. Previous reports examining SI physiology demonstrate that cTBS over SI suppresses ipsilateral somatosensory evoked potentials (P25/N33) for 13 minutes following stimulation [24].…”

Section: Introductionmentioning

confidence: 99%

“…Further, decreased oxy-hemoglobin concentrations in contralateral SI and primary motor cortex (M1) are also observed following cTBS over SI [25]. In the present study, we investigate the influence of cTBS over SI on TOJ and TOJ-S. Psychophysical measures were obtained from the right hand before and for up to 34 minutes following real and sham cTBS over left-hemisphere SI [9]. …”

Section: Introductionmentioning

confidence: 99%

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Continuous theta-burst stimulation modulates tactile synchronization

et al. 2013

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BackgroundTemporal order judgement (TOJ) is the ability to detect the order of occurrence of two sequentially delivered stimuli. Previous research has shown that TOJ in the presence of synchronized periodic conditioning stimuli impairs TOJ performance, and this phenomenon is suggested to be mediated by GABAergic interneurons that cause perceptual binding across the two skin sites. Application of continuous theta-burst repetitive TMS (cTBS) over primary somatosensory cortex (SI) alters temporal and spatial tactile perception. The purpose of this study was to examine TOJ perception in the presence and absence of synchronized periodic conditioning stimuli before and after cTBS applied over left-hemisphere SI. A TOJ task was administered on the right index and middle finger (D2 and D3) in two separate sessions in the presence and absence of conditioning stimuli (a background low amplitude sinusoidal vibration).ResultsCTBS reduced the impact of the conditioning stimuli on TOJ performance for up to 18 minutes following stimulation while sham cTBS did not affect TOJ performance. In contrast, the TOJ task performed in the absence of synchronized conditioning stimulation was unaltered following cTBS.ConclusionWe conclude that cTBS suppresses inhibitory networks in SI that mediate perceptual binding during TOJ synchronization. CTBS offers one method to suppress cortical excitability in the cortex and potentially benefit clinical populations with altered inhibitory cortical circuits. Additionally, TOJ measures with conditioning stimuli may provide an avenue to assess sensory processing in neurologically impaired patient populations.

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Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch‐regulation in nonsingers

Finkel

Veit

Lotze

et al. 2019

Human Brain Mapping

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While the significance of auditory cortical regions for the development and maintenance of speech motor coordination is well established, the contribution of somatosensory brain areas to learned vocalizations such as singing is less well understood. To address these mechanisms, we applied intermittent theta burst stimulation (iTBS), a facilitatory repetitive transcranial magnetic stimulation (rTMS) protocol, over right somatosensory larynx cortex (S1) and a nonvocal dorsal S1 control area in participants without singing experience. A pitch‐matching singing task was performed before and after iTBS to assess corresponding effects on vocal pitch regulation. When participants could monitor auditory feedback from their own voice during singing (Experiment I), no difference in pitch‐matching performance was found between iTBS sessions. However, when auditory feedback was masked with noise (Experiment II), only larynx‐S1 iTBS enhanced pitch accuracy (50–250 ms after sound onset) and pitch stability (>250 ms after sound onset until the end). Results indicate that somatosensory feedback plays a dominant role in vocal pitch regulation when acoustic feedback is masked. The acoustic changes moreover suggest that right larynx‐S1 stimulation affected the preparation and involuntary regulation of vocal pitch accuracy, and that kinesthetic‐proprioceptive processes play a role in the voluntary control of pitch stability in nonsingers. Together, these data provide evidence for a causal involvement of right larynx‐S1 in vocal pitch regulation during singing.

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Continuous theta-burst rTMS over primary somatosensory cortex modulates tactile perception on the hand

Cited by 36 publications

References 71 publications

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

A vibrotactile behavioral battery for investigating somatosensory processing in children and adults

Continuous theta-burst stimulation modulates tactile synchronization

Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch‐regulation in nonsingers

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