Continuous propofol anaesthesia for patients with myotonic dystrophy

Bennun, Meir; Goldstein, Bernard D.; Finkelstein, Y.; Jedeikin, Robert

doi:10.1093/bja/85.3.407

Cited by 45 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tzabar et al [2] reported prolonged recovery time from propofol anesthesia; however, a high target concentration (6 mg ml -1 ) during surgery might be the reason for delayed recovery. Other reports [4,5] showed rapid emergence from anesthesia from continuous propofol infusion.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Target-controlled infusion of propofol for a patient with myotonic dystrophy

et al. 2005

View full text Add to dashboard Cite

We present a patient with myotonic dystrophy (MD) who was anesthetized with propofol using a target-controlled technique for electrophysiologic examination and cardiac catheter ablation. The patient became apneic unexpectedly at the same time when he fell asleep, with effect-site propofol concentration of 1.6 microg ml(-1). We had to insert a laryngeal mask airway (LMA), and mechanical ventilation was performed. The patient opened his eyes on verbal command at an effect-site concentration of 1.2 microg ml(-1) after the procedure. This concentration (1.2 microg ml(-1)) was slightly lower than our institutional average for adult male patients (1.5 +/- 0.2 microg ml(-1)). However, the time from the end of anesthesia to the patient's awakening was about 10 min. We considered that emergence from anesthesia was not delayed in this case. Careful titration of propofol by target-controlled infusion (TCI) enabled to evaluate the patient's sensitivity to propofol. We conclude that TCI of propofol was a useful anesthetic technique in the MD patient. Respiratory depression might occur in MD patients at low propofol concentrations. Precise control and titration over target propofol concentration is important in anesthetic management for MD patients.

show abstract

Section: Discussionmentioning

confidence: 90%

“…In some reports, propofol had been successfully used [4,5]. However, other reports suggested prolonged recovery [2], exaggerated physiologic responses [3], and myotonia [6].…”

Section: Discussionmentioning

confidence: 99%

Target-controlled infusion of propofol for a patient with myotonic dystrophy

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Propofol has been used in patients with myotonia with variable responses, including prolonged recovery, altered dose-response curves, precipitation of myotonias and uneventful administration. [78] Considering this we used propofol for induction only and not for maintenance of anaesthesia. As our patient had absence of cardiovascular system involvement, we used desflurane for the maintenance of anaesthesia and it provided good control over anaesthetic depth as well as haemodynamics.…”

Section: Discussionmentioning

confidence: 99%

Desflurane anaesthesia in myotonic dystrophy

2011

View full text Add to dashboard Cite

Myotonic dystrophy (MD) is a rare genetic disorder with multisystem involvement characterised by myotonia and progressive muscle weakness and wasting. These patients pose significant challenges to the anaesthesiologist in view of the muscular and extramuscular involvement and sensitivity to anaesthetic drugs. The literature is replete with reports of postanaesthetic respiratory and cardiovascular complications in these patients. But an ideal anaesthetic technique in MD patients remains to be determined. Rapid recovery is desirable to reduce postoperative respiratory complications. Though there are a few case reports of maintenance of anaesthesia with isoflurane and sevoflurane, there are scanty reports of use of desflurane in these patients. We present successful management of a patient with MD for laparoscopic cholecystectomy using a carefully titrated desflurane-based anaesthesia and discuss the perioperative considerations.

show abstract

“…PSA agents such as propofol, narcotics, benzodiazepines, and ketamine all have case reports describing their successful use in children with unusual inborn errors of metabolism. [75][76][77][78][79][80][81][82][83][84] Metabolism or excretion of any sedation or analgesia agent may be prolonged in children with liver or kidney problems. These effects do not impact the initial dosing of a sedative or narcotic, only the timing and amount of subsequent doses.…”

Section: Endocrine/metabolic Problemsmentioning

confidence: 99%

Procedural Sedation for Children With Special Health Care Needs

Sacchetti

Turco²,

Carraccio³

et al. 2003

Pediatric Emergency Care

View full text Add to dashboard Cite

Children with special health care needs represent a growing percentage of pediatric patients treated in all emergency departments. Substantial literature exists concerning the medical treatment of these patients, but there is little written describing the management of procedural sedation or analgesia in this population. This article examines the unique anatomic and physiologic implications of procedural sedation or analgesia management in children with special health care needs.

show abstract

Continuous propofol anaesthesia for patients with myotonic dystrophy

Cited by 45 publications

References 22 publications

Target-controlled infusion of propofol for a patient with myotonic dystrophy

Target-controlled infusion of propofol for a patient with myotonic dystrophy

Desflurane anaesthesia in myotonic dystrophy

Procedural Sedation for Children With Special Health Care Needs

Contact Info

Product

Resources

About