Continuous particle focusing in a waved microchannel using negative dc dielectrophoresis

Li, Ming; Li, Shunbo; Cao, Wenbin; Li, Weihua; Wen, Weijia; Alici, Gürsel

doi:10.1088/0960-1317/22/9/095001

Cited by 46 publications

(57 citation statements)

References 45 publications

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“…It could be found that applied voltages at both inlet and outlet could affect particle trajectory, and 15 μm particles can be directed into either outlet 1 or outlet 2 depending on the applied voltages. In addition, with the increase of inlet and/or outlet voltage, 15 μm particles were observed to obtain a better focusing effect (forced into a narrower stream), which corresponds to our pervious founding [12]. By setting the correction factor to be 0.4 for 15 μm particles, the numerically predicted results (right column) coincide acceptably with the experimentally obtained superimposed images.…”

Section: Numerical Simulationsupporting

confidence: 84%

Section: Theory and Mechanismmentioning

confidence: 99%

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Continuous particle manipulation and separation in a hurdle-combined curved microchannel using DC dielectrophoresis

Li¹,

Li²,

Li³

et al. 2013

AIP Conference Proceedings

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Section: Numerical Simulationsupporting

confidence: 84%

Section: Theory and Mechanismmentioning

confidence: 99%

Continuous particle manipulation and separation in a hurdle-combined curved microchannel using DC dielectrophoresis

Li¹,

Li²,

Li³

et al. 2013

AIP Conference Proceedings

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“…Various manipulation techniques have already been proposed and developed to focus particles in microfluidics, such as dielectrophoresis [4][5], magnetophoresis [6][7] and acoustophoresis [8][9].…”

Section: Introductionmentioning

confidence: 99%

Inertial focusing in a straight channel with asymmetrical expansion–contraction cavity arrays using two secondary flows

Zhang

et al. 2013

J. Micromech. Microeng.

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G. (2013). Inertial focusing in a straight channel with asymmetrical expansion-contraction cavity arrays using two secondary flows. Journal of Micromechanics and Microengineering, 23 (8), 1-13. Inertial focusing in a straight channel with asymmetrical expansioncontraction cavity arrays using two secondary flows AbstractThe focusing of particles has a variety of applications in industry and biomedicine, including wastewater purification, fermentation filtration, and pathogen detection in flow cytometry, etc. In this paper a novel inertial microfluidic device using two secondary flows to focus particles is presented. The geometry of the proposed microfluidic channel is a simple straight channel with asymmetrically patterned triangular expansion-contraction cavity arrays. Three different focusing patterns were observed under different flow conditions: (1) a single focusing streak on the cavity side; (2) double focusing streaks on both sides; (3) half of the particles were focused on the opposite side of the cavity, while the other particles were trapped by a horizontal vortex in the cavity. The focusing performance was studied comprehensively up to flow rates of 700 μl min−1. The focusing mechanism was investigated by analysing the balance of forces between the inertial lift forces and secondary flow drag in the cross section. The influence of particle size and cavity geometry on the focusing performance was also studied. The experimental results showed that more precise focusing could be obtained with large particles, some of which even showed a single-particle focusing streak in the horizontal plane. Meanwhile, the focusing patterns and their working conditions could be adjusted by the geometry of the cavity. This novel inertial microfluidic device could offer a continuous, sheathless, and high-throughput performance, which can be potentially applied to high-speed flow cytometry or the extraction of blood cells. (1) single focusing streak on cavity side; (2) double focusing streaks on both sides; (3) half of particles focused on the opposite side of cavity, and other particles trapped by horizontal vortex in cavity. The focusing performance was studied comprehensively up to the flow rates of 700 µl min -1 . The focusing mechanism was investigated by analyzing force balance between inertial lift forces and secondary flow drag in the cross section.The influence of particle size and cavity geometry on the focusing performance was also studied. Experimental results showed that a more pronounced focusing performance can be obtained with large particles, which even showed a single-particle focusing streak in horizontal plane. Meanwhile, focusing patterns and their working conditions were adjustable by the geometry of cavity. The novel inertial microfluidic device was capable of offering a continuous, sheathless, and high-throughput performance, which can be potentially applied to highspeed flow cytometry or extraction of blood cells.

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“…Consider a particle subjected to negative DEP effect passing though the microchannel under the combined effect of EOF and EP, repulsive DEP forces (dark blue arrows, relatively weak in the curved section, while strong in the constricted region) are exerted on the particle all along its movement. The polydimethylsiloxane (PDMS) microfluidic channel was fabricated using standard soft-lithography technique, and a detailed fabrication process can be found in our previous work [15]. As shown in Figure (2), the microfluidic chip is composed of two semi-circular channels that each integrates with three round hurdles from inner wall, one inlet (A) and two outlet (B and C) reservoirs, and three straight connecting microchannels.…”

Section: Theorymentioning

confidence: 99%

Dielectrophoretic manipulation and separation of particles in an S-shaped microchannel with hurdles

et al. 2013

2013 IEEE/ASME International Conference on Advanced Intelligent Mechatronics

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This paper presents a novel dielectrophoresis (DEP)-based microfluidic device, which incorporates multiple round hurdles within an S-shaped curved microchannel for continuous manipulation and separation of microparticles. Local nonuniform electric fields are induced by means of both constricted gaps formed between hurdles and outer channel wall, and variable current lengths in curved sections with equal width. Under the effect of negative DEP, particles will be directed away from either inner wall or hurdle edge, as they transport throughout the microchannel electrokinetically. Both experiment and numerical simulation were conducted, the results of which showed that fix-sized (i.e. 10 or 15 Pm) polystyrene (PS) particles could be successfully switched, directed and focused by adjusting applied voltages at inlet and outlets, and size-based separation of 10 and 15 Pm particles was achieved with a careful selection of applied voltages. Compared to other microchannel designs that make use of either obstacle or curvature individually for inhomogeneous electric fields, this design offers advantages such as improved controllability over particle motion, lower requirement of applied voltage, reduced fouling and particle adhesion, etc. Abstract-This paper presents a novel dielectrophoresis (DEP)-based microfluidic device, which incorporates multiple round hurdles within an S-shaped curved microchannel for continuous manipulation and separation of microparticles. Local nonuniform electric fields are induced by means of both constricted gaps formed between hurdles and outer channel wall, and variable current lengths in curved sections with equal width. Under the effect of negative DEP, particles will be directed away from either inner wall or hurdle edge, as they transport throughout the microchannel electrokinetically. Both experiment and numerical simulation were conducted, the results of which showed that fix-sized (i.e. 10 or 15 µm) polystyrene (PS) particles could be successfully switched, directed and focused by adjusting applied voltages at inlet and outlets, and size-based separation of 10 and 15 µm particles was achieved with a careful selection of applied voltages. Compared to other microchannel designs that make use of either obstacle or curvature individually for inhomogeneous electric fields, this design offers advantages such as improved controllability over particle motion, lower requirement of applied voltage, reduced fouling and particle adhesion, etc.

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Continuous particle focusing in a waved microchannel using negative dc dielectrophoresis

Cited by 46 publications

References 45 publications

Continuous particle manipulation and separation in a hurdle-combined curved microchannel using DC dielectrophoresis

Continuous particle manipulation and separation in a hurdle-combined curved microchannel using DC dielectrophoresis

Inertial focusing in a straight channel with asymmetrical expansion–contraction cavity arrays using two secondary flows

Dielectrophoretic manipulation and separation of particles in an S-shaped microchannel with hurdles

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