Continuous particle manipulation and separation in a hurdle-combined curved microchannel using DC dielectrophoresis

Li, Ming; Li, Shunbo; Li, Weihua; Wen, Weijia; Alici, Gürsel

doi:10.1063/1.4812140

Cited by 3 publications

(1 citation statement)

References 12 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cells experience high electric fields and deflection by DEP forces only within this region, thus minimizing exposure to its dangerous influence. Variations on the hurdle shape have been proposed, i.e., multiple rectangular insulating hurdles [ 164 ], triangular hurdles within an H-shaped microchannel [ 165 , 166 ] and S-shaped hurdles [ 167 ]. Hurdle designs have been used to separate biological cells [ 168 ] and DNA molecules [ 169 ].…”

Section: Separation Based On Electrical Propertiesmentioning

confidence: 99%

Microfluidic Platform for Cell Isolation and Manipulation Based on Cell Properties

Yousuff

et al. 2017

Micromachines

View full text Add to dashboard Cite

In molecular and cellular biological research, cell isolation and sorting are required for accurate investigation of a specific cell types. By employing unique cell properties to distinguish between cell types, rapid and accurate sorting with high efficiency is possible. Though conventional methods can provide high efficiency sorting using the specific properties of cell, microfluidics systems pave the way to utilize multiple cell properties in a single pass. This improves the selectivity of target cells from multiple cell types with increased purity and recovery rate while maintaining higher throughput comparable to conventional systems. This review covers the breadth of microfluidic platforms for isolation of cellular subtypes based on their intrinsic (e.g., electrical, magnetic, and compressibility) and extrinsic properties (e.g., size, shape, morphology and surface markers). The review concludes by highlighting the advantages and limitations of the reviewed techniques which then suggests future research directions. Addressing these challenges will lead to improved purity, throughput, viability and recovery of cells and be an enabler for novel downstream analysis of cells.

show abstract

Section: Separation Based On Electrical Propertiesmentioning

confidence: 99%

Microfluidic Platform for Cell Isolation and Manipulation Based on Cell Properties

Yousuff

et al. 2017

Micromachines

View full text Add to dashboard Cite

show abstract

On the use of correction factors for the mathematical modeling of insulator based dielectrophoretic devices

Hill

Lapizco‐Encinas

2019

Electrophoresis

View full text Add to dashboard Cite

Mathematical modeling is a fundamental component in the development of new microfluidics techniques and devices. Modeling allows for the rapid testing of new system configurations while saving resources. Microscale electrokinetic (EK) techniques have significantly benefited by the advances in modeling programs and software packages. However, EK phenomena are complex to model, as they dynamically affect system characteristics, including the physical properties of the particles and fluid within the system. Insulator‐based dielectrophoresis (iDEP) is an EK technique that has received important attention during the last two decades. In particular, numerous research groups that study iDEP systems employ a combination of modeling and experimentation for developing new iDEP systems. An important fraction of these research groups has adopted the practice of employing “correction factors” to account for EK phenomena that cannot be accurately predicted in their models due to model complexity and limitations in computing resources. The present review article aims to provide the reader with an overview of the most common approaches in the use of correction factors for the modeling of iDEP systems.

show abstract

Continuous separation of multiple size microparticles using alternating current dielectrophoresis in microfluidic device with acupuncture needle electrodes

Tao

Ren

Yan

et al. 2015

Chin. J. Mech. Eng.

View full text Add to dashboard Cite

Continuous particle manipulation and separation in a hurdle-combined curved microchannel using DC dielectrophoresis

Cited by 3 publications

References 12 publications

Microfluidic Platform for Cell Isolation and Manipulation Based on Cell Properties

Microfluidic Platform for Cell Isolation and Manipulation Based on Cell Properties

On the use of correction factors for the mathematical modeling of insulator based dielectrophoretic devices

Continuous separation of multiple size microparticles using alternating current dielectrophoresis in microfluidic device with acupuncture needle electrodes

Contact Info

Product

Resources

About