Continuous manufacturing as an enabling tool with green credentials in early-phase pharmaceutical chemistry

Martin, Benjamin; Lehmann, Hansjörg; Yang, Hongwei; Chen, Like; Tian, Xiangguang; Polenk, Jutta; Schenkel, Berthold

doi:10.1016/j.cogsc.2018.03.005

Cited by 25 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many recent reviews on flow chemistry as a means of being Green for academic and industrial settings are currently available, with Lummiss et al, Martin et al, Dallinger et al, to name a few of the recent examples. [61][62][63] However, few reports treat continuous manufacturing as a holistic approach to improving Green manufacturing. The plethora of unit oper-ations available to chemists and chemical engineers have been redesigned for continuous API manufacturing, typically as isolated steps.…”

Section: Flow Chemistrymentioning

confidence: 99%

Continuous manufacturing – the Green Chemistry promise?

2019

View full text Add to dashboard Cite

show abstract

Section: Flow Chemistrymentioning

confidence: 99%

Continuous manufacturing – the Green Chemistry promise?

2019

View full text Add to dashboard Cite

show abstract

“…The improved selectivity, and often yield, are attributed to more efficient heat-transfer and mixing efficiency , that are achievable in the flow system. The smaller-scale architectures present in the flow system offer higher surface area to volume when compared with traditional batch vessels. , These advantages can address a number of key priority areas including sustainable chemistry to lead to cleaner, more efficient, less consumptive, and safer chemical processes, as well as the area of novel and efficient chemical synthesis. It is also well accepted that future industrial systems using continuous flow will lead to increased automation in manufacturing operations thereby lowering Operating Expenditure (OPEX).…”

Section: Introductionmentioning

confidence: 99%

A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

Baumann

Moody

Smyth

et al. 2020

Org. Process Res. Dev.

350

237

View full text Add to dashboard Cite

Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and critically, the ability to perform chemistry that is difficult or impossible to do in batch mode. Globally, significant efforts have been made to develop the manufacturing flexibility and robustness of processes used to produce chemicals in a continuous way, yet despite these scientific developments, a major challenge for industry is the established application of flow technology to commercially relevant examples. The identification of opportunities to apply flow solutions to current processes is also critical to the success of this new technology for pharmaceutical and fine chemical companies. This review highlights industrial hurdles and the importance of education and showcases recent (2018−2019) and relevant industrial examples where utilization of flow technology has been successfully performed.

show abstract

“…13–25 The smaller-scale architectures present in the flow system provide higher surface area to volume ratios when compared with traditional batch vessels. 26,27 These structural advantages can enhance mass and heat transfer coefficients by 1–2 orders of magnitude and enable high volumetric productivity in industrial synthesis. 28 In general, the main advantages of flow chemistry (Fig.…”

Section: Introductionmentioning

confidence: 99%