“…It is believed that the higher concentration of CDDP perfusing the sacral plexus is the etiologic factor precipitating the neuropathy (18,20). Kavanagh et al (18), LaPolla et al (20), and Roberts et al (26) in a previous study of continuous intra-arterial infusion CDDP with or without the fluorouracil derivative 2-deoxy-5-fluorouridine, noted that 11-37% of patients developed neuropathy of the lower extremity. Because the optimal platinum drug dosage, time interval, and sequence of intra-arterial cisplatin in conjunction with radiation are unknown, neurotoxicity should be carefully documented in the future.…”