Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma

Yin, Yifei; Jiang, Xingwu; Sun, Liping; Li, Hongyan; Su, Chunxia; Zhang, Yan; Xu, Gelin; Li, Xiao‐Long; Zhao, Chong‐Ke; Chen, Yu; Xu, Hui‐Xiong; Zhang, Kun

doi:10.1016/j.nantod.2020.101009

Cited by 150 publications

(107 citation statements)

References 47 publications

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“…6 a). In addition, they have enabled SDT-based nanoparticles with continuous CO 2 bubble generation to promote ROS production and enhance the effect of ICD against breast carcinoma [ 152 ]. Recently, there is a growing perspective that induced ROS can be depleted by reductive species (such as GSH) for intra-tumoral redox metabolism equilibrium.…”

Section: Application Of Nanomedicines In Treating Cold Tumorsmentioning

confidence: 99%

Recent Advancements in Nanomedicine for ‘Cold’ Tumor Immunotherapy

Chen¹,

Sun²

2021

Nano-Micro Lett.

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Although current anticancer immunotherapies using immune checkpoint inhibitors (ICIs) have been reported with a high clinical success rate, numerous patients still bear ‘cold’ tumors with insufficient T cell infiltration and low immunogenicity, responding poorly to ICI therapy. Considering the advancements in precision medicine, in-depth mechanism studies on the tumor immune microenvironment (TIME) among cold tumors are required to improve the treatment for these patients. Nanomedicine has emerged as a promising drug delivery system in anticancer immunotherapy, activates immune function, modulates the TIME, and has been applied in combination with other anticancer therapeutic strategies. This review initially summarizes the mechanisms underlying immunosuppressive TIME in cold tumors and addresses the recent advancements in nanotechnology for cold TIME reversal-based therapies, as well as a brief talk about the feasibility of clinical translation.

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Section: Application Of Nanomedicines In Treating Cold Tumorsmentioning

confidence: 99%

Recent Advancements in Nanomedicine for ‘Cold’ Tumor Immunotherapy

Chen¹,

Sun²

2021

Nano-Micro Lett.

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“…Electron spin resonance (ESR) was further used to examine the scavenging ability of PMPB NC using 5,5-dimethyl-1-pyrroline N-oxide I (DMPO) as the capturing agent [ 37 , 38 ]. Herein, the Fenton reaction between FeSO 4 and H 2 O 2 was adopted to give birth to free hydroxyl radicals (·OH) for assessing the scavenging ability of PMPB NC.…”

Section: Resultsmentioning

confidence: 99%

Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis

et al. 2021

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Background As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It has been extensively accepted that oxidative stress and inflammation closely correlate with the evolution of atherosclerotic plaques, and they directly participate in all stages of atherosclerosis. Regarding this, anti-oxidation or anti-inflammation drugs were developed to enable anti-oxidative therapy and anti-inflammation therapy against atherosclerosis. However, current drugs failed to meet clinical demands. Methods Nanomedicine and nanotechnology hold great potential in addressing the issue. In this report, we engineered a simvastatin (Sim)-loaded theranostic agent based on porous manganese-substituted prussian blue (PMPB) analogues. The biomimetic PMPB carrier could scavenge ROS and mitigate inflammation in vitro and in vivo. Especially after combining with Sim, the composite Sim@PMPB NC was expected to regulate the processes of atherosclerosis. As well, Mn2+ release from PMPB was expected to enhance MRI. Results The composite Sim@PMPB NC performed the best in regulating the hallmarks of atherosclerosis with above twofold decreases, typically such as oxidative stress, macrophage infiltration, plaque density, LDL internalization, fibrous cap thickness and foam cell birth, etc. Moreover, H2O2-induced Mn2+ release from PMPB NC in atherosclerotic inflammation could enhance MRI for visualizing plaques. Moreover, Sim@PMPB exhibited high biocompatibility according to references and experimental results. Conclusions The biomimetic Sim@PMPB theranostic agent successfully stabilized atherosclerotic plaques and alleviated atherosclerosis, and also localized and magnified atherosclerosis, which enabled the monitoring of H2O2-associated atherosclerosis evolution after treatment. As well, Sim@PMPB was biocompatible, thus holding great potential in clinical translation for treating atherosclerosis. Graphic abstract

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“…The increase of ROS is one of the main causes of immunosuppression in the TME (106). However, some studies have shown that increasing ROS levels can induce immunogenic death (ICD) in tumor cells (107,108), which exhibits a synergistic effect with immunotherapy (107). A growing body of evidence suggests that targeting the redox levels of immune cells can result in a variety of phenotypes and functions, which can overcome immunosuppression in the TME to ultimately inhibit tumor growth (21,22).…”

Section: Ros and Cafsmentioning

confidence: 99%

“…These processes can provide potential antigen stimulation to the immune system. A nano-study based on sonodynamic therapy found that enhanced continuous ultrasonic-triggered inertial cavitation increased ROS production and induced strong ICD (107). This was characterized by increased antigen exposure and presentation, enhanced maturation of DCs and increased infiltration of active-effector CD8 + T cells (107).…”

Section: Ros and Icdmentioning

confidence: 99%

Role of reactive oxygen species in tumors based on the ‘seed and soil’ theory: A complex interaction (Review)

Liang

et al. 2021

Oncol Rep

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Tumor microenvironment (TME) can serve as the 'soil' for the growth and survival of tumor cells and function synergically with tumor cells to mediate tumor progression and therapeutic resistance. Reactive oxygen species (ROS) is somewhat of a double-edged sword for tumors. Accumulating evidence has reported that regulating ROS levels can serve an anti-tumor role in the TME, including the promotion of cancer cell apoptosis, inhibition of angiogenesis, preventing immune escape, manipulating tumor metabolic reorganization and improving drug resistance. In the present review, the potential role of ROS in anti-tumor therapy was summarized, including the possibility of directly or indirectly targeting the TME. Contents 1. Introduction 2. ROS and TME 3. ROS and tumor drug resistance 4. Conclusions

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Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma

Cited by 150 publications

References 47 publications

Recent Advancements in Nanomedicine for ‘Cold’ Tumor Immunotherapy

Recent Advancements in Nanomedicine for ‘Cold’ Tumor Immunotherapy

Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis

Role of reactive oxygen species in tumors based on the ‘seed and soil’ theory: A complex interaction (Review)

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