Continuous growth phenomenon for direct synthesis of monodisperse water-soluble iron oxide nanoparticles with extraordinarily high relaxivity

Cheah, Pohlee; Cowan, Terriona; Zhang, Rong; Fatemi‐Ardekani, Ali; Liu, Yongjian; Zheng, Jie; Han, Fengxiang X.; Li, Yu; Cao, Dongmei; Zhao, Yongfeng

doi:10.1039/d0nr01552k

Cited by 18 publications

(14 citation statements)

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“…The iron oxide nanoparticles were synthesized at elevated temperatures in DEG. 18 The size can be controlled by sequentially adding the Fe(acac) 3 precursor. The iron oxide nanoparticles have very good size control and great dispersibility in water.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The synthesis of iron oxide nanoparticles follows our previous study. 18 Typically, Fe(acac) 3 (88 mg, 0.25 mmol) was mixed and stirred with 2.5 mL of DEG (0.1 mmol Fe/ml) in a three-necked flask under argon gas exchange to obtain solution A. In another flask, Fe(acac) 3 (211 mg, 0.6 mmol) was mixed with 6 mL of DEG (0.1 mmol Fe/ml) and the mixture was stirred under argon to obtain solution B.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…The density of surface ligands on the surface of iron oxide nanoparticles was according to the previous study. 18 After purified nanoparticles were dispersed in Milli-Q water or PBS buffer solution (1× ), pictures were taken immediately and after 7 days to observe the stability. XPS was performed using a Thermo Fisher ESCALAB Xi+ spectrometer equipped with a monochromatic Al X-ray source (1486.6 eV).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…17 Recently, we reported a continuous growth of iron oxide nanoparticles in polyols. 18 The size of iron oxide nanoparticles can be controlled precisely by the addition of precursors. Potentially, nanoparticles with nanometer-scale size increments can be achieved.…”

Section: ■ Introductionmentioning

confidence: 99%

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Versatile Surface Functionalization of Water-Dispersible Iron Oxide Nanoparticles with Precisely Controlled Sizes

Cheah

Brown

et al. 2021

Langmuir

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The synthesis of highly water-dispersible iron oxide nanoparticles with surface functional groups and precisely controlled sizes is essential for biomedical application. In this paper, we report a one-pot strategy for versatile surface functionalization. The iron oxide nanoparticles are first synthesized by thermal decomposition of iron(III) acetylacetonate (Fe(acac)3) in diethylene glycol (DEG), and their surfaces are modified by adding the surface ligands at the end of the reaction. The size of iron oxide nanoparticles can be precisely controlled in nanometer scale by continuous growth. This facile synthesis method enables the surface modification with different coating materials such as dopamine (DOPA), polyethylene glycol with thiol end group (thiol-PEG), and poly(acrylic acid) (PAA) onto the iron oxide nanoparticles, introducing new surface functionalities for future biomedical application. From transmission electron microscopy (TEM) and X-ray diffraction (XRD), the morphology and crystal structure are not changed during surface functionalization. The attachment of surface ligands is studied by Fourier transform infrared spectroscopy (FTIR) and Thermogravimetric Analysis (TGA). The surface functional groups are confirmed by X-ray Photoelectron Spectroscopy (XPS). In correlation with the change of hydrodynamic size, PAA coated nanoparticles are found to exhibit outstanding stability in aqueous solution. Furthermore, we demonstrate that the functional groups are available for conjugating with other molecules such as fluorescent dye, showing potential biological applications. Lastly, the magnetic resonance phantom studies demonstrate that iron oxide nanoparticles with PAA coating can be used as T 1 and T 2 dual-modality contrast agents. Both r 1 and r 2 relaxivities significantly increase after surface functionalization with PAA, indicating improved sensitivity.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Versatile Surface Functionalization of Water-Dispersible Iron Oxide Nanoparticles with Precisely Controlled Sizes

Cheah

Brown

et al. 2021

Langmuir

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“…Iron oxide nanoparticles such as magnetite Fe 3 O 4 or maghemite γ-Fe 2 O 3 are promising materials for applications in biomedicine and bioengineering areas [1][2][3]30 These nanoparticles have attracted great interest due to their unique properties 4,31 such as narrow size distribution, biocompatibility, non-toxicity, and ability to be detected and manipulated with an external magnetic field. Both are generally appropriate and safe for in vivo biomedical applications 4 .…”

Section: Introductionmentioning

confidence: 99%

Conjugation strategies on functionalized iron oxide nanoparticles as a malaria vaccine delivery system

Al-Abboodi

Alsaady

Banoon

et al. 2021

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Vaccination has been used effectively to protect from infectious diseases and non-infectious diseases such as cancer and allergies. Different forms of particulate arrangements, including nanoparticles, virus-like particles (VLPs), and virosomes, have been built recently depending on the type of pathogen to be targeted. The ability to conjugate the recombinant Plasmodium yoelii, 19-kDa C-terminal fragment of merozoite surface protein 1 (PyMSP119) on the surface of superparamagnetic magnetite nanoparticles (SPIONs) was explored as a new technique of enhancing vaccination against malaria. Different conjugation strategies were performed to correlate the effects of nanoparticle chemistry surfaces to bind later with the malaria protein. (SPIONs) were prepared by chemical coprecipitation method and coated with 3-aminopropyltriethoxysilane (APTS) alone (as a surface coater), or with both APTS and polyethylene glycol (PEG) (as a shield to protect the malaria protein from proteolytic enzymes) by using a modified silanisation method. X-ray powder diffraction (XRD, Philips Model) patterns indicated that the SPIONs were of high purity with an inverse spinal structure. Fourier Transform Infrared Spectroscopy (FTIR) was collected using PerkinElmer Spectrum 100 Series; spectra of uncoated and coated magnetite nanoparticles confirmed that the silane layer had been coated on the surface Fe3O4. The SPIONs were superparamagnetic as investigated by Vibrating Sample Magnetometry (VSM, Princeton Applied Research, model ISS) and relatively stable in aqueous phase at room temperature and could also be quickly recovered from suspension using an external magnet. Introduce the carboxyl groups onto the SPIONs surfaces, resulting in a relatively high protein binding capacity onto the nanoparticle surfaces. The bare particles had a mean size of around 20 nm with a relatively narrow size distribution. 82% of African Green Monkey fibroblast (COS-7) were alive in nanoparticle suspension using the MTT assay method. The quantity of protein explicitly bound to particles was determined using Sodium Dodecyl Sulfate (SDS) - Polyacrylamide Gel Electrophoresis (PAGE). SDS–PAGE. When the conjugation blend was prepared in EDC, there was approximately 100% binding between PyMSP119 and the Fe3O4-COOH particles because no protein band was apparent at the expected molecular weight for PyMSP119 (45 kDa). The current study investigates the theory that the gradual, persistent release of the malaria antigen may stimulate and maintain an elevated level of immune response for an extended period in vivo, which will be the scope of future work.

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One Step Superparamagnetic Iron Oxide Nanoparticles by a Microwave Process: Optimization of Microwave Parameters with an Experimental Design

Girardet,

Kessler,

Migot

et al. 2024

Part & Part Syst Charact

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Superparamagnetic iron oxide nanoparticles (SPIONs) are nanoparticles used in a lot of applications such as batteries, and biomedical, … To obtain these nanoparticles, several techniques exist such as coprecipitation, thermal decomposition, sol–gel process but they have some advantages (synthesis in a water media, high crystallinity, high monodispersity) and disadvantages (using an organic solvent, large distribution of size, poor crystallinity). The goal of this work is to synthesize SPIONs for biomedical applications (for example as a contrast agent for the MRI): SPIONs should be stable in an aqueous media, monodisperse, and have good crystallinity and magnetic properties. To achieve this result, a microwave process is carried out. However, any study describes the microwave parameter on the synthesis of the nanoparticles. This work offers to determine the best conditions of the microwave to obtain ideal SPIONs for MRI. For this, an experimental design is carried out to determine these parameters thanks to different techniques of characterization (Transmission Electronic Microscopy, Dynamic Light Scattering, X‐ray diffraction, Thermogravimetric Analysis, magnetic characterizations). With the different results of these characterizations, the best conditions of the microwave are determined, and a simulation of all experiments is realized with a surface response.

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Continuous growth phenomenon for direct synthesis of monodisperse water-soluble iron oxide nanoparticles with extraordinarily high relaxivity

Abstract: A continuous growth phenomenon is discovered for the synthesis of iron oxide nanoparticles with nanometer-scale size control in an amphiphilic solvent. The as-prepared nanoparticles are extremely water soluble without any surface modification.

Cited by 18 publications

References 70 publications

Versatile Surface Functionalization of Water-Dispersible Iron Oxide Nanoparticles with Precisely Controlled Sizes

Versatile Surface Functionalization of Water-Dispersible Iron Oxide Nanoparticles with Precisely Controlled Sizes

Conjugation strategies on functionalized iron oxide nanoparticles as a malaria vaccine delivery system

One Step Superparamagnetic Iron Oxide Nanoparticles by a Microwave Process: Optimization of Microwave Parameters with an Experimental Design

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