Continuous Full-Time Occlusion of the Sound Eye Vs Full-Time Occlusion of the Sound Eye Periodically Alternating with Occlusion of the Amblyopic Eye in Treatment of Amblyopia: A Prospective Randomized Study

Stanković, Branislav; Milenković, S

doi:10.1177/112067210701700103

Cited by 7 publications

(2 citation statements)

References 29 publications

(28 reference statements)

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“…Typically, patients with mild to moderate amblyopia are prescribed complete occlusion for 2-6 waking hours per day, over several months to more than a year (Pediatric Eye Disease Investigator Group 2003a,b; Repka et al 2003;Stewart et al 2004Stewart et al , 2006. Patients with moderate to severe amblyopia are often prescribed 6-10 h or more than a day (Pediatric Eye Disease Investigator Group 2003a,b), and some clinicians recommend more aggressive full-time occlusion for severe amblyopia (Dorey et al 2001;Bhola et al 2006;Stankovic & Milenkovic 2007). As reported in a recent large-scale clinical study of children (3-8 years of age), the dose-response rate for occlusion is approximately 0.1 log unit (1 chart line) per 120 h of occlusion, and the treatment efficacy is 3-4 logMAR lines (Stewart et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Improving the performance of the amblyopic visual system

Levi

2008

Phil. Trans. R. Soc. B

128

116

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Experience-dependent plasticity is closely linked with the development of sensory function; however, there is also growing evidence for plasticity in the adult visual system. This review re-examines the notion of a sensitive period for the treatment of amblyopia in the light of recent experimental and clinical evidence for neural plasticity. One recently proposed method for improving the effectiveness and efficiency of treatment that has received considerable attention is 'perceptual learning'. Specifically, both children and adults with amblyopia can improve their perceptual performance through extensive practice on a challenging visual task. The results suggest that perceptual learning may be effective in improving a range of visual performance and, importantly, the improvements may transfer to visual acuity. Recent studies have sought to explore the limits and time course of perceptual learning as an adjunct to occlusion and to investigate the neural mechanisms underlying the visual improvement. These findings, along with the results of new clinical trials, suggest that it might be time to reconsider our notions about neural plasticity in amblyopia.

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Section: Introductionmentioning

confidence: 99%

Improving the performance of the amblyopic visual system

Levi

2008

Phil. Trans. R. Soc. B

128

116

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“…One RCT including five patients with SDA was found, but it had investigated the effectiveness of an educational program on the predictors of noncompliance to occlusion therapy (Loudon 2006). Five additional RCTs investigated occlusion therapy (Hertle 2007;Repka 2007;Stankovic 2007;Stewart 2007;Wallace 2006) but these included only strabismic or anisometropic amblyopia, or both. Thus, the search did not identify any new trials which met the inclusion criteria for the review.…”

Section: Results Of the Searchmentioning

confidence: 99%

Occlusion for stimulus deprivation amblyopia

Antonio-Santos¹,

Vedula

Hatt

et al. 2014

Cochrane Database of Systematic Reviews

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Background-Stimulus deprivation amblyopia (SDA) develops due to an obstruction to the passage of light secondary to a condition such as cataract. The obstruction prevents formation of a clear image on the retina. SDA can be resistant to treatment, leading to poor visual prognosis. SDA probably constitutes less than 3% of all amblyopia cases, although precise estimates of prevalence are unknown. In developed countries, most patients present under the age of one year; in less developed parts of the world patients are likely to be older at the time of presentation. The mainstay of treatment is removal of the cataract and then occlusion of the better-seeing eye, but regimens vary, can be difficult to execute, and traditionally are believed to lead to disappointing results.Objectives-Our objective was to evaluate the effectiveness of occlusion therapy for SDA in an attempt to establish realistic treatment outcomes. Where data were available, we also planned to examine evidence of any dose response effect and to assess the effect of the duration, severity, and causative factor on the size and direction of the treatment effect.

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Interventions for stimulus deprivation amblyopia

Hatt

Antonio-Santos

Powell

et al. 2006

Cochrane Database of Systematic Reviews

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Background Stimulus deprivation amblyopia (SDA) develops due to an obstruction to the passage of light, preventing clear formation of an image on the retina (e.g. cataract, ptosis). It is particularly severe and can be resistant to treatment, leading to poor visual prognosis. Precise estimates of SDA prevalence are difficult to come by but it probably constitutes less than 3% of all amblyopia cases. In developed countries, most patients present under the age of one; in less developed parts of the world, presentation is likely to be significantly later than this. The mainstay of treatment is occlusion of the better-seeing eye, but regimens vary, can be difficult to execute and are traditionally believed to lead to disappointing results. Objectives The objectives of this review were to evaluate the effectiveness of occlusion treatment for SDA, to establish the optimum treatment regimen, to determine the factors that may affect outcome, and to identify realistic treatment goals. Search methods We searched the Cochrane Central Register of Controlled Trials-CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register

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Continuous Full-Time Occlusion of the Sound Eye Vs Full-Time Occlusion of the Sound Eye Periodically Alternating with Occlusion of the Amblyopic Eye in Treatment of Amblyopia: A Prospective Randomized Study

Cited by 7 publications

References 29 publications

Improving the performance of the amblyopic visual system

Improving the performance of the amblyopic visual system

Occlusion for stimulus deprivation amblyopia

Interventions for stimulus deprivation amblyopia

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