Continuous flow synthesis of nanoparticles using ceramic microfluidic devices

Pedro, Sara Gómez‐de; Puyol, Mar; Alonso-Chamarro, Julián

doi:10.1088/0957-4484/21/41/415603

Cited by 46 publications

(25 citation statements)

References 53 publications

(49 reference statements)

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“…[163] Generally, shrinking entire chemical and analytical laboratories on a single microchip would be the ultimate goal. [179] Different types of materials, such as glass, [180] silicon, [181] ceramic, [182] polymers (PVC and PEEK), and stainless steel can be used to make MF devices. Operating conditions, ease of fabrication, and type of chemistry process define what construction material to be selected.…”

Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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“…A pulsed dosage of 0.5 µL of a 1 mM Au(III) solution (every 2 s) to a continuous flow of a 1.5 mM sodium borohydride solution was proposed by Pedro et al [36]. The two solutions were mixed in a flow-focusing T-junction connected to a three-dimensional serpentine channel network Ultra-small Au nanoparticles can also be obtained by rapid heating and quench in a microreactor system [37].…”

Section: Transient Operationmentioning

confidence: 99%

Microreactors for Gold Nanoparticles Synthesis: From Faraday to Flow

Rahman

Rebrov

2014

Processes

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Abstract:The seminal work of Michael Faraday in 1850s transmuted the "Alchemy of gold" into a fascinating scientific endeavor over the millennia, particularly in the past half century. Gold nanoparticles (GNPs) arguably hold the central position of nanosciences due to their intriguing size-and-shape dependent physicochemical properties, non-toxicity, and ease of functionalization and potential for wide range of applications. The core chemistry involved in the syntheses is essentially not very different from what Michael Faraday resorted to: transforming ions into metallic gold using mild reducing agents. However, the process of such reduction and outcome (shapes and sizes) are intricately dependent on basic operational parameters such as sequence of addition and efficiency of mixing of the reagents. Hence, irreproducibility in synthesis and maintaining batch-to-batch quality are major obstacles in this seemingly straightforward process, which poses challenges in scaling-up. Microreactors, by the virtue of excellent control over reagent mixing in space and time within narrow channel networks, opened a new horizon of possibilities to tackle such problems to produce GNPs in more reliable, reproducible and scalable ways. In this review, we will delineate the state-of-the-art of GNPs synthesis using microreactors and will discuss in length how such "flask-to-chip" paradigm shift may revolutionize the very concept of nanosyntheses.

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“…This 3D device is operated in the coaxial flow regimen in order to carry out the nanoprecipitation process [38,39].…”

Section: Fabrication Of Ltcc 3d Microfluidic Reactorsmentioning

confidence: 99%

LTCC-3D Coaxial Flow Focusing Microfluidic Reactor for Micro and Nanoparticle Fabrication and Production Scale-Out

Gongora-Rubio¹,

Schianti²,

Gomez³

et al. 2013

Journal of Microelectronics and Electronic Packaging

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AbstractÀMiniaturization of chemical processes is becoming a must for green chemistry and sustainable industry processes, so technological research in this direction is well received. Continuous microreactor systems hold many potential benefits over batch reactors, in that they allow: high surface-to-volume ratio, fine adjustment of chemical reaction residence times, small thermal inertia, and fast changes in temperature. Advantages of multilayer green ceramics for microprocess applications include: that the LTCC substrate is chemically inert to most solvents, that it has a high contact angle, that it presents low thermal coefficient of expansion, and that it can withstand high operational temperatures and high internal pressures. For these reasons, LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical processes, making it an enabling technology for the miniaturization of chemical processes. In fact, recently, LTCC microfluidic reactors have been used to produce microparticles and nanoparticles with excellent control of size distribution and morphology. The present work provides a report on the performance of a 3D LTCC coaxial flow focusing microfluidic reactor designed to fabricate microparticles and nanoparticles using nanoprecipitation through an antisolvent; with electric potential size tuning. We also implement an approach to particle production scale-out.

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Continuous flow synthesis of nanoparticles using ceramic microfluidic devices

Cited by 46 publications

References 53 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Microreactors for Gold Nanoparticles Synthesis: From Faraday to Flow

LTCC-3D Coaxial Flow Focusing Microfluidic Reactor for Micro and Nanoparticle Fabrication and Production Scale-Out

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