Continuous-flow particle guiding based on dipolar coupled magnetic superstructures in rotating magnetic fields

Eickenberg, Bernhard; Wittbracht, Frank; Stohmann, Patrick; Schubert, Jennifer-Rose; Brill, Christopher; Weddemann, Alexander; Hütten, Andreas

doi:10.1039/c2lc41316g

Cited by 20 publications

(11 citation statements)

References 49 publications

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“…Active micromixers depend on different external energy sources to disturb the fluids, increase the contact area, or induce the chaotic advection, thus enhancing the mixing effect. Based on the types of external energy sources, the active micromixers can be further categorized as pressure field driven [ 7 , 13 , 14 , 15 , 16 ], electrical field driven [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], sound field driven [ 6 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], magnetic field driven [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ], and thermal field driven [ 58 ,…”

Section: Active Micromixersmentioning

confidence: 99%

A Review on Micromixers

et al. 2017

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Microfluidic devices have attracted increasing attention in the fields of biomedical diagnostics, food safety control, environmental protection, and animal epidemic prevention. Micromixing has a considerable impact on the efficiency and sensitivity of microfluidic devices. This work reviews recent advances on the passive and active micromixers for the development of various microfluidic chips. Recently reported active micromixers driven by pressure fields, electrical fields, sound fields, magnetic fields, and thermal fields, etc. and passive micromixers, which owned two-dimensional obstacles, unbalanced collisions, spiral and convergence-divergence structures or three-dimensional lamination and spiral structures, were summarized and discussed. The future trends for micromixers to combine with 3D printing and paper channel were brought forth as well.

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Section: Active Micromixersmentioning

confidence: 99%

A Review on Micromixers

et al. 2017

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“…Such methods are derived from continuous flow separation techniques in which magnetic particles in a sample stream are pulled into an adjacent buffer stream to extract a target analyte that has become bound to the particles. [12][13][14][15][16] However, by generating multilaminar flow streams in a microfluidic chamber, consisting of alternating streams of reagents and washing solutions, particles can be deflected consecutively through each stream, thus performing sequential reactions/binding events. [17][18][19][20][21][22][23][24] This concept can also be flipped, in that rather than deflecting magnetic particles through continuously flowing streams of solutions via a fixed magnet, they are instead pulled by a moving magnet through static solutions.…”

Section: Introductionmentioning

confidence: 99%

Phaseguide assisted liquid lamination for magnetic particle-based assays

et al. 2014

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We have developed a magnetic particle-based assay platform in which functionalised magnetic particles are transferred sequentially through laminated volumes of reagents and washing buffers. Lamination of aqueous liquids is achieved via the use of phaseguide technology; microstructures that control the advancing air-liquid interface of solutions as they enter a microfluidic chamber. This allows manual filling of the device, eliminating the need for external pumping systems, and preparation of the system requires only a few minutes. Here, we apply the platform to two on-chip strategies: (i) a one-step streptavidin-biotin binding assay, and (ii) a two-step C-reactive protein immunoassay. With these, we demonstrate how condensing multiple reaction and washing processes into a single step significantly reduces procedural times, with both assay procedures requiring less than 8 seconds.

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“…In addition, it is more costly compared with a passive micro-mixer. Examples of external energy sources used for active micro-mixers are acoustic [3], magnetic [4], electric [5], thermal [6], electro [7,8], and pressure fluctuating [9]. On the contrary, passive micro-mixers use micro-mixer geometry to agitate and generate secondary flow.…”

Section: Introductionmentioning

confidence: 99%

Mixing Performance of a Passive Micro-Mixer with Mixing Units Stacked in Cross Flow Direction

Juraeva

Kang

2021

Micromachines

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A new passive micro-mixer with mixing units stacked in the cross flow direction was proposed, and its performance was evaluated numerically. The present micro-mixer consisted of eight mixing units. Each mixing unit had four baffles, and they were arranged alternatively in the cross flow and transverse direction. The mixing units were stacked in four different ways: one step, two step, four step, and eight step stacking. A numerical study was carried out for the Reynolds numbers from 0.5 to 50. The corresponding volume flow rate ranged from 6.33 μL/min to 633 μL/min. The mixing performance was analyzed in terms of the degree of mixing (DOM) and relative mixing energy cost (MEC). The numerical results showed a noticeable enhancement of the mixing performance compared with other micromixers. The mixing enhancement was achieved by two flow characteristics: baffle wall impingement by a stream of high concentration and swirl motion within the mixing unit. The baffle wall impingement by a stream of high concentration was observed throughout all Reynolds numbers. The swirl motion inside the mixing unit was observed in the cross flow direction, and became significant as the Reynolds number increased to larger than about five. The eight step stacking showed the best performance for Reynolds numbers larger than about two, while the two step stacking was better for Reynolds numbers less than about two.

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Continuous-flow particle guiding based on dipolar coupled magnetic superstructures in rotating magnetic fields

Cited by 20 publications

References 49 publications

A Review on Micromixers

A Review on Micromixers

Phaseguide assisted liquid lamination for magnetic particle-based assays

Mixing Performance of a Passive Micro-Mixer with Mixing Units Stacked in Cross Flow Direction

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