Continuous Flow Hydration of Pyrazine‐2‐carbonitrile in a Manganese Dioxide Column Reactor

Abstract

A procedure that yields pyrazinamide as a fine white powder is presented. A glass column reactor is used containing Celite and manganese dioxide and is mounted vertically in a heating jacket. Following the procedure are notes on the instruments and chemicals used and required. The chapter concludes with a discussion on the general concepts regarding preparation of pyrazinamide.

Integrated plug flow synthesis and crystallisation of pyrazinamide

“…1). 13,14 The reported method achieved clean conversion to the product in high chemical yields. In this communication we report the high yielding plug flow coupling of this chemistry with crystallisation techniques for the preparation and crystallisation of pyrazinamide with a residence time (RT) of 32 min 17 s. Solid form (polymorph) selectivity has also been achieved in the integrated process, a vital consideration in prospective end-to-end process design for solid state materials such as pharmaceuticals.…”