Continuous Flow Bead-Bed Dissolution Apparatus for Suppositories

FIP/AAPS Joint Workshop Report: Dissolution/In Vitro Release Testing of Novel/Special Dosage Forms

“…Lipophilic suppositories may undergo several phases before the release of the API such as softening, deformation melting, or disintegration accompanied by spreading[3637]. The initial phase is the greatest source of variability for in vitro testing of drug release due to the variability in the surface area exposed to the medium[3738]. Secondly, variability is introduced via the partitioning of the drug in solution and molten and dispersed matrix[343839].…”

The Release of Isoconazole Nitrate from Different Suppository Bases: In-vitro Dissolution, Physicochemical and Microbiological Studies

“…(Kapas et al 1979), whereas the fourth employs dialysis tubing or a natural membrane (Plaxco et al 1967). The fifth type involves a flow system in which the sample is placed on cotton or a wire screen (Puffer & Crowell 1973;Roseman et al 1981). According to the second type, dissolution-controlled drug release was investigated using a British Pharmacopoeia dissolution apparatus in this study.…”

Sustained release applications of a fluoroalkyl ester-functionalized amphiphilic cyclodextrin by inclusion complex formation with water-soluble drugs in supercritical carbon dioxide

“…Although it has been reported that viscous oils can be used as sustained release vehicles for hydrophobic substances, the immediate release of MOL from the oily suspension into aqueous solution suggests that peanut oil works merely as a drug carrier in the case of a simple suspension of hydrophilic MOL in peanut oil [26]. The release of drug from a vehicle is known to be influenced by various factors including drug-vehicle interactions, solubility, partition coefficient, and the particle size of drug in the vehicle [27]. MOL was practically insoluble in peanut oil and its solubility was not increased by complexation with g-CyD-F.…”