Continuous fiberoptic arterial oxygen tension measurements in dogs

Abstract

An experimental study using a new fiberoptic sensor for the continuous intraarterial measurement of oxygen tension is described. This "optode" sensor uses the phenomenon of fluorescence quenching to determine the oxygen tension of the surrounding medium. To assess the accuracy of this device, we anesthetized 4 dogs and monitored them continuously with arterial catheters and an intraarterial optode probe, and intermittently with arterial blood gas analysis. The inspired oxygen fraction was varied from 1.0 to 0.1, and arterial blood gases were measured for comparison with the optode reading. Two hundred ninety data sets yielded a correlation coefficient of 0.96, with a linear regression slope of 0.98 and intercept of 5.1 mm Hg. In the 72 data sets from the last dog, the bias and precision of the optode arterial oxygen tension values were -10.3 mm Hg and 20.0 mm Hg, respectively. The optode probe was easily inserted through a 20-gauge catheter and did not interfere with continuous arterial pressure measurement or blood sampling. This study suggests that the optode has great potential as a continuous, real-time monitor of arterial oxygen tension.

Progress in the development of a fluorescent intravascular blood gas system in man

“…Other probes to measure pH, PCO2, and PO2 have been described [2,[14][15][16][17][18][19][20]. None of these probes measures all variables simultaneously.…”

“…Bias and precision were found to be 9.1 and 19.6 mm Hg. The latter is based on the phenomenon of fluorescence and was studied in dogs [14]. Bias and precision were 2.7 and 37.3 mm Hg.…”

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“…Unlike on-demand catheters, IABG monitors offer the interesting possibility of ensuring real-time continuous measurement of arterial blood gases [22]. Based on the same optode technology as the EABG devices, this technique differs because the sensor is directly inserted into the arterial blood stream.…”