Continuous aerosolised tribavirin for respiratory syncytial virus infection in lung transplant recipients

Low incidence of severe respiratory syncytial virus infections in lung transplant recipients despite the absence of specific therapy

“…40 In conclusion, our observations support that LTRs without severe disease due to RSV, and without particularly enhanced immunosuppression (eg, anti-thymocyte globulins), do not necessarily require specific anti-viral treatment. This contrasts with previous reports and expert opinions, [41][42][43][44][45][46] which favor early specific anti-RSV treatment in LTRs. However, most of these earlier studies were retrospective, included small numbers of patients, assessed several different respiratory viruses, and contained incomplete clinical information.…”

Intravenous Ribavirin Is a Safe and Cost-effective Treatment for Respiratory Syncytial Virus Infection After Lung Transplantation

“…24 Clearly, optimal therapy for RSV-related pulmonary infection after LTx has not been established. 1,4,23,25,26 Reports of the use of intravenous ribavirin therapy are limited to small case series and case reports, primarily involving the pediatric and BMT populations. [27][28][29][30][31] There is no substantive experience in SOT patients.…”

RSV prevention and treatment in pediatric lung transplant patients: A survey of current practices among the International Pediatric Lung Transplant Collaborative

“…To our knowledge, this is the first survey to examine RSV prevention and management strategies in pediatric lung transplant centers internationally. Therapeutic strategies in the prevention and treatment of RSV infection have only been studied in adult lung transplant patients (3,5,6,11,12,14). In these adults, communityacquired RVIs including RSV are an independent risk factor for BOS, acute rejection, chronic graft dysfunction, and death (15)(16)(17)(18)(19).…”

“…BMT patients with symptomatic RSV URTI have a 50% risk of developing LRTI, and LRTI carries a mortality rate of 31-100% regardless of treatment in this population (21,(24)(25)(26)(27). RSV URTIs reported in adult lung transplant recipients have been linked to significant morbidity and impact on lung function (11,12,28,29). Therefore, vigilance in reporting URTIs during the RSV season and prompt investigation seem prudent.…”