Continuous Active State of Coagulation System in Patients With Nonthrombotic Inflammatory Bowel Disease

Abstract

This study was planned for searching possible changes of the total coagulation and fibrinolysis system in inflammatory bowel disease (IBD) in order to obtain some clues for explaining the relation between IBD and hypercoagulability. A total of 24 patients with ulcerative colitis, 12 patients with Crohn disease, and 20 healthy controls were studied. Platelets; prothrombin time (PT); partial thromboplastin time (PTT); fibrinogen; D-dimer; fibrinogen degradation products; protein C; protein S; antithrombin; thrombin time; von Willebrand factor; coagulation factors V, VII, VIII, IX, XI, and XIII; plasminogen; antiplasmin; tissue plasminogen activator; plasminogen activator inhibitor 1; and prothrombin fragments 1 + 2 were studied. Most of the procoagulants (platelets, fibrinogen, von Willebrand factor, coagulation factor IX, and plasminogen activator inhibitor 1) were found increased together with decreases in some anticoagulants (protein S and antithrombin) in IBD. Also the activation markers of coagulation (D-dimer, fibrinogen degradation products, and prothrombin fragments 1 + 2) were all increased. The parameters of the total coagulation-fibrinolysis system were increased in IBD, regardless of the form and the activity of the disease.

Genetic Dissection of TAM Receptor-Ligand Interaction in Retinal Pigment Epithelial Cell Phagocytosis

“…In tissues, these same cells may be exposed to Protein S produced by activated T cells (Smiley et al, 1997). Defects in the phagocytic clearance of ACs from lymphoid tissues are strongly linked to the development of human autoimmune disorders (Gaipl et al, 2007; Nagata et al, 2010); and Protein S deficiency is associated with the development of both systemic lupus and inflammatory bowel disease (Alkim et al, 2011; Suh et al, 2010). Together, these observations suggest that, in select settings, Protein S may be the TAM ligand of greatest biological significance.…”

Construction of a scoring system for predicting the risk of severe gastrointestinal involvement in Henoch-Schönlein Purpura

“…Kawasaki disease, another systemic vasculitis common in children, often presents as hyponatremia and hypoalbuminemia, especially in severe cases (Fukunishi et al 2000; Kobayashi et al 2006). Further, patients with ulcerative colitis present with elevated D-dimer levels (Alkim et al 2011; Zezos et al 2009) and decreased fXIII activity (Lorenz et al 1991), reflecting the inflammation of and injury to the intestinal mucosa. In consideration of these facts, our results might be regarded as reflecting severe vasculitis and the subsequent destruction of the small vessels, resulting in massive injury to the intestinal mucosa.…”

Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study

“…Many chronic inflammatory diseases, including inflammatory bowel diseases [3,4], rheumatic arthritis [5,6], COPD [7-9], and sarcoidosis [10], are associated with increased coagulability of blood. This procoagulant state has also been observed in the airways of patients with stable asthma as reflected by increased levels of tissue factor (TF), thrombin-antithrombin complexes (TATc) and the plasminogen activator inhibitor-1 (PAI-1), as well as decreased levels of the natural anticoagulant protein C [11].…”