Loss of asthma control can be discriminated from clinically stable episodes by longitudinal monitoring of exhaled metabolites measured by GC/MS and particularly eNose. Part of the uncovered biomarkers was associated with sputum eosinophils. These findings provide proof of principle for monitoring and identification of loss of asthma control by breathomics.
Four-week treatment with synbiotics had no effect on bronchial inflammation and LAR, but did significantly reduce systemic production of Th2-cytokines after allergen challenge and improved PEF.
To cite this article: Schouten M, van de Pol MA, Levi M, van der Poll T, van der Zee JS. Early activation of coagulation after allergen challenge in patients with allergic asthma. J Thromb Haemost 2009; 7: 1592-4.
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